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Protein

Disintegrin EMF10A

Gene
N/A
Organism
Eristicophis macmahoni (Leaf-nosed viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1). Partially inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM. Weakly inhibits ADP-induced platelet aggregation.1 Publication

Caution

Eristocophin I appears to represent degradation product of EMF10A.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin EMF10A
Short name:
EMF-10A
Alternative name(s):
Eristocophin I
Platelet aggregation activation inhibitor
OrganismiEristicophis macmahoni (Leaf-nosed viper)
Taxonomic identifieri110227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEristicophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018031 – 69Disintegrin EMF10AAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 30PROSITE-ProRule annotation1 Publication
Disulfide bondi8Interchain (with C-11 in EMF10B)PROSITE-ProRule annotation1 Publication
Disulfide bondi13Interchain (with C-16 in EMF10B)PROSITE-ProRule annotation1 Publication
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation1 Publication
Disulfide bondi26 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi39 ↔ 58PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with EMF10B; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81742
SMRiP81742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 66DisintegrinPROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 45Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P81742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSANPCCDP ITCKPKKGEH CVSGPCCRNC KFLNPGTICK KGRGDNLNDY
60
CTGVSSDCPR NPWKSEEED
Length:69
Mass (Da):7,554
Last modified:May 30, 2000 - v1
Checksum:iE200B3E89DC18FAD
GO

Similar proteinsi

Entry informationi

Entry nameiDIDAA_ERIMA
AccessioniPrimary (citable) accession number: P81742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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