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Protein

Troponin C, skeletal muscle

Gene
N/A
Organism
Anguilla anguilla (European freshwater eel) (Muraena anguilla)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding EF-hand for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi28 – 391PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi64 – 752PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi104 – 1153PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi140 – 1514PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Short name:
TNC
OrganismiAnguilla anguilla (European freshwater eel) (Muraena anguilla)
Taxonomic identifieri7936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737091 – 160Troponin C, skeletal muscleAdd BLAST160

Proteomic databases

PRIDEiP81660

Structurei

3D structure databases

ProteinModelPortaliP81660
SMRiP81660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 160EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG012180

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P81660-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PTDAQTDARS FLSEEMIAEF KAAFDMFDTD GGGDISTKEL GTVMRMLGQN
60 70 80 90 100
PTREELDAII EEVDEDGSGT IDFEEFLVMM VRQLKEDQAG KSEEELAEFF
110 120 130 140 150
RVFDKNGDGF IDREEFGEIL RSSGEPVSEE EIDELMADGD KNNDGKIDFD
160
EWLKMMENIQ
Length:160
Mass (Da):18,132
Last modified:June 1, 2001 - v1
Checksum:i2503CE5AA3AA64B1
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP81660
SMRiP81660
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP81660

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012180

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_ANGAN
AccessioniPrimary (citable) accession number: P81660
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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