Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (17 Jun 2020)
Sequence version 2 (23 Jan 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Dermcidin

Gene

DCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).1 Publication
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+Note: Mn2+ is required for survival-promoting peptide.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide, Hydrolase, Protease
LigandManganese

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157 Antimicrobial peptides

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.108.1.1 the pore-forming dermcidin (dermcidin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dermcidin (EC:3.4.-.-)
Alternative name(s):
Preproteolysin
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCD
Synonyms:AIDD, DSEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161634.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14669 DCD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606634 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P81605

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
117159

Open Targets

More...
OpenTargetsi
ENSG00000161634

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27171

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P81605 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141302

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 193 PublicationsAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002108120 – 110DermcidinAdd BLAST91
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002108220 – 49Survival-promoting peptideAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002108350 – 621 PublicationAdd BLAST13
PeptideiPRO_000002108463 – 109DCD-1Add BLAST47
PropeptideiPRO_00004083121101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P81605

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P81605

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P81605

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P81605

PeptideAtlas

More...
PeptideAtlasi
P81605

PRoteomics IDEntifications database

More...
PRIDEi
P81605

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57698 [P81605-1]
57699 [P81605-2]
57700 [P81605-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P81605-1 [P81605-1]

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P81605

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P81605

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P81605

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161634 Expressed in skin of leg and 72 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P81605 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000161634 Group enriched (breast, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125564, 77 interactors

Protein interaction database and analysis system

More...
IntActi
P81605, 33 interactors

Molecular INTeraction database

More...
MINTi
P81605

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P81605 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P81605

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P81605

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KF1A Eukaryota
ENOG411167G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2060627_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P81605

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWVLGAP

Database of Orthologous Groups

More...
OrthoDBi
1488134at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P81605

TreeFam database of animal gene trees

More...
TreeFami
TF340896

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028130 Dermcidin

The PANTHER Classification System

More...
PANTHERi
PTHR40711:SF1 PTHR40711:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15291 Dermcidin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P81605-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFMTLLFLT ALAGALVCAY DPEAASAPGS GNPCHEASAA QKENAGEDPG
60 70 80 90 100
LARQAPKPRK QRSSLLEKGL DGAKKAVGGL GKLGKDAVED LESVGKGAVH
110
DVKDVLDSVL
Length:110
Mass (Da):11,284
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23666FBD20019465
GO
Isoform 2 (identifier: P81605-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-110: AVHDVKDVLDSVL → GEERLVFGAPVNLTSIPLTSVSRP

Show »
Length:121
Mass (Da):12,414
Checksum:i1ED0E009B72ADA55
GO
Isoform 3 (identifier: P81605-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-77: PCHEASAAQK...KGLDGAKKAV → HKQMDCLQLQ...AKPPHTRGLV
     78-110: Missing.

Show »
Length:77
Mass (Da):8,295
Checksum:i60CB579573DA59AA
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 4702.57 Da. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04376533 – 77PCHEA…AKKAV → HKQMDCLQLQKPPSETAKFL SSSTNLPRREKLVPSAKPPH TRGLV in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_04376678 – 110Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04376798 – 110AVHDV…LDSVL → GEERLVFGAPVNLTSIPLTS VSRP in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF144011 mRNA Translation: AAL18349.1
AY044239 Genomic DNA Translation: AAK94785.1
AF418981 Genomic DNA Translation: AAL25801.1
AY590150 mRNA Translation: AAS99907.1
EF503687 mRNA Translation: ABQ53649.1
EF503688 mRNA Translation: ABQ53650.1
EF503689 mRNA Translation: ABQ53651.1
AC079310 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96794.1
BC062682 mRNA Translation: AAH62682.1
BC069108 mRNA Translation: AAH69108.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73478.1 [P81605-2]
CCDS8884.1 [P81605-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001287783.1, NM_001300854.1 [P81605-2]
NP_444513.1, NM_053283.3 [P81605-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293371; ENSP00000293371; ENSG00000161634 [P81605-1]
ENST00000456047; ENSP00000406773; ENSG00000161634 [P81605-2]
ENST00000546807; ENSP00000450415; ENSG00000161634 [P81605-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:117159

UCSC genome browser

More...
UCSCi
uc001sgj.4 human [P81605-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Smart sweat - Issue 18 of January 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144011 mRNA Translation: AAL18349.1
AY044239 Genomic DNA Translation: AAK94785.1
AF418981 Genomic DNA Translation: AAL25801.1
AY590150 mRNA Translation: AAS99907.1
EF503687 mRNA Translation: ABQ53649.1
EF503688 mRNA Translation: ABQ53650.1
EF503689 mRNA Translation: ABQ53651.1
AC079310 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96794.1
BC062682 mRNA Translation: AAH62682.1
BC069108 mRNA Translation: AAH69108.1
CCDSiCCDS73478.1 [P81605-2]
CCDS8884.1 [P81605-1]
RefSeqiNP_001287783.1, NM_001300854.1 [P81605-2]
NP_444513.1, NM_053283.3 [P81605-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSGNMR-A63-110[»]
2NDKNMR-A63-110[»]
2YMKX-ray2.49A/B/C63-110[»]
6SHKX-ray1.99A63-110[»]
SMRiP81605
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125564, 77 interactors
IntActiP81605, 33 interactors
MINTiP81605
STRINGi9606.ENSP00000406773

Chemistry databases

DrugBankiDB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Protein family/group databases

TCDBi1.C.108.1.1 the pore-forming dermcidin (dermcidin) family

PTM databases

iPTMnetiP81605
PhosphoSitePlusiP81605

Polymorphism and mutation databases

BioMutaiDCD
DMDMi20141302

2D gel databases

UCD-2DPAGEiP81605

Proteomic databases

EPDiP81605
jPOSTiP81605
MassIVEiP81605
PaxDbiP81605
PeptideAtlasiP81605
PRIDEiP81605
ProteomicsDBi57698 [P81605-1]
57699 [P81605-2]
57700 [P81605-3]
TopDownProteomicsiP81605-1 [P81605-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27554 196 antibodies

The DNASU plasmid repository

More...
DNASUi
117159

Genome annotation databases

EnsembliENST00000293371; ENSP00000293371; ENSG00000161634 [P81605-1]
ENST00000456047; ENSP00000406773; ENSG00000161634 [P81605-2]
ENST00000546807; ENSP00000450415; ENSG00000161634 [P81605-3]
GeneIDi117159
KEGGihsa:117159
UCSCiuc001sgj.4 human [P81605-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
117159
DisGeNETi117159
EuPathDBiHostDB:ENSG00000161634.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCD
HGNCiHGNC:14669 DCD
HPAiENSG00000161634 Group enriched (breast, skin)
MIMi606634 gene
neXtProtiNX_P81605
OpenTargetsiENSG00000161634
PharmGKBiPA27171

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KF1A Eukaryota
ENOG411167G LUCA
GeneTreeiENSGT00940000163391
HOGENOMiCLU_2060627_0_0_1
InParanoidiP81605
OMAiEWVLGAP
OrthoDBi1488134at2759
PhylomeDBiP81605
TreeFamiTF340896

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
117159 1 hit in 787 CRISPR screens
EvolutionaryTraceiP81605

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Dermcidin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
117159
PharosiP81605 Tbio

Protein Ontology

More...
PROi
PR:P81605
RNActiP81605 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161634 Expressed in skin of leg and 72 other tissues
GenevisibleiP81605 HS

Family and domain databases

InterProiView protein in InterPro
IPR028130 Dermcidin
PANTHERiPTHR40711:SF1 PTHR40711:SF1, 1 hit
PfamiView protein in Pfam
PF15291 Dermcidin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81605
Secondary accession number(s): A5JHP2
, A5JHP3, P58461, Q53YJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2002
Last modified: June 17, 2020
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again