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Protein

Alcohol dehydrogenase class-3 chain H

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.By similarity

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Sitei116Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 chain H (EC:1.1.1.1By similarity)
Alternative name(s):
Alcohol dehydrogenase class-III chain H
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607631 – 375Alcohol dehydrogenase class-3 chain HAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine2 Publications1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP81600

Interactioni

Subunit structurei

Homodimer or heterodimer with L chain.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81600
SMRiP81600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOVERGENiHBG000195

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P81600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ATAGQVIKCK AAVAWEAGKP LSLEEVEVAP PRAGEVRIKV VATGVCHTDA
60 70 80 90 100
YTLSGSDPEG AFPVILGHEG AGLVESVGEG VTKFKAGDTV IPLYVPQCGE
110 120 130 140 150
CKFCKNPKTN LCQKIRVTQG RGLMPDNTSR FTCKGKQLFH FMGTSTFSEY
160 170 180 190 200
TVVADISLAN VDPKAPLDKV CLLGCGISTG YGAALNTAKV EPGSTCAVFG
210 220 230 240 250
LGAVGLAAIM GCKVAGATRI IGVDINPEKF GKAAEFGATE CLNPKDHARP
260 270 280 290 300
VQEVLVEMTD GGVDYSFECI GNVEIMRSAL EACHKGWGES VIIGVAGAGQ
310 320 330 340 350
EIATRPFQLV TGRVWKATAF GGWKSVESVP KLVEDYMNKK LKVDEFVTHT
360 370
LPFDSINEGF DLMHAGKSIR CVLTF
Length:375
Mass (Da):39,669
Last modified:July 15, 1999 - v1
Checksum:i0B9760AB77329FE3
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP81600
SMRiP81600
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP81600

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOVERGENiHBG000195

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHH_GADMO
AccessioniPrimary (citable) accession number: P81600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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