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UniProtKB - P81544 (DEFN_HELVI)
Protein
Defensin heliomicin
Gene
N/A
Organism
Heliothis virescens (Tobacco budworm moth)
Status
Functioni
This peptide has potent anti-fungal activity. Has no activity against Gram-negative and Gram-positive bacteria.
GO - Biological processi
- defense response to fungus Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- killing of cells of another organism Source: UniProtKB-KW
Keywordsi
Molecular function | Antimicrobial, Defensin, Fungicide |
Biological process | Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Defensin heliomicin |
Organismi | Heliothis virescens (Tobacco budworm moth) |
Taxonomic identifieri | 7102 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Noctuoidea › Noctuidae › Heliothinae › Heliothis |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074477 | 1 – 44 | Defensin heliomicinAdd BLAST | 44 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 7 ↔ 32 | |||
Disulfide bondi | 18 ↔ 40 | |||
Disulfide bondi | 22 ↔ 42 |
Keywords - PTMi
Disulfide bondStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P81544 |
SMRi | P81544 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P81544 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR001542, Defensin_invertebrate/fungal IPR036574, Scorpion_toxin-like_sf |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51378, INVERT_DEFENSINS, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 4784.8 Da. Determined by MALDI. 1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I2U | NMR | - | A | 1-44 | [»] | |
1I2V | NMR | - | A | 1-44 | [»] | |
AlphaFoldDBi | P81544 | |||||
SMRi | P81544 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P81544 |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR001542, Defensin_invertebrate/fungal IPR036574, Scorpion_toxin-like_sf |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51378, INVERT_DEFENSINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DEFN_HELVI | |
Accessioni | P81544Primary (citable) accession number: P81544 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 30, 2000 | |
Last modified: | May 25, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families