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Protein

Complement factor B-like protease

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required in both the classical and alternate pathways of the complement system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement alternate pathway, Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-2132273 Formation of membrane-bound convertase C3
R-GGA-2132281 Regulation of complement cascades
R-GGA-2132285 Complement Cascade
R-GGA-2132293 Formation of fluid-phase convertase C3

Protein family/group databases

MEROPSiS01.196

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor B-like protease (EC:3.4.21.-)
Cleaved into the following 2 chains:
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000275571 – ›250Complement factor B-like proteaseAdd BLAST›250
ChainiPRO_00000275581 – 232Complement factor B-like protease Ba fragmentAdd BLAST232
ChainiPRO_0000027559233 – ›250Complement factor B-like protease Bb fragmentAdd BLAST›18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 44By similarity
Disulfide bondi30 ↔ 71By similarity
Disulfide bondi76 ↔ 118By similarity
Disulfide bondi104 ↔ 131By similarity
Glycosylationi115N-linked (GlcNAc...) asparagine1
Disulfide bondi138 ↔ 178By similarity
Disulfide bondi164 ↔ 191By similarity
Glycosylationi221N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Plasma.

Structurei

3D structure databases

ProteinModelPortaliP81475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 73Sushi 1PROSITE-ProRule annotationAdd BLAST71
Domaini74 – 133Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini136 – 193Sushi 3PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Sushi

Phylogenomic databases

HOVERGENiHBG072124
PhylomeDBiP81475

Family and domain databases

CDDicd00033 CCP, 2 hits
InterProiView protein in InterPro
IPR028341 Complement_B
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF394 PTHR19325:SF394, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81475-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ATTRCDPTLI PIAGGWFELL EGGEALRYRC PPGHIPTPLA RRSCGPDGQX
60 70 80 90 100
EPLXXXXXXX XXXXXXXXXK CRAVWCPPPQ DMEHGSFWPR LPRYPPGSRL
110 120 130 140 150
HFQCFQGFNL RGAPNRTCGE GGRWSGVTPV CDDGSGDCPA PPVXXXXXKE
160 170 180 190 200
GSRYLLEDTV RFRCGPGLVL LGSAVRQCLE GGVWSGTEPQ CRAPLSFDTP
210 220 230 240 250
SDVAASFMAS LSQSVERADS NSSHGPTEKL PRXIRVDGSA XLNVFLLXDA
Length:250
Mass (Da):27,059
Last modified:December 15, 1998 - v1
Checksum:i8DEFE8454838C923
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei2501

Cross-referencesi

3D structure databases

ProteinModelPortaliP81475
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.196

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG072124
PhylomeDBiP81475

Enzyme and pathway databases

ReactomeiR-GGA-2132273 Formation of membrane-bound convertase C3
R-GGA-2132281 Regulation of complement cascades
R-GGA-2132285 Complement Cascade
R-GGA-2132293 Formation of fluid-phase convertase C3

Family and domain databases

CDDicd00033 CCP, 2 hits
InterProiView protein in InterPro
IPR028341 Complement_B
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF394 PTHR19325:SF394, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCFBL_CHICK
AccessioniPrimary (citable) accession number: P81475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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