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Protein

Equistatin

Gene
N/A
Organism
Actinia equina (Beadlet anemone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent inhibitor of papain-like cysteine proteinases.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI31.003

Names & Taxonomyi

Protein namesi
Recommended name:
Equistatin
OrganismiActinia equina (Beadlet anemone)
Taxonomic identifieri6106 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaActiniidaeActinia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001959001 – 199EquistatinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 24PROSITE-ProRule annotation
Disulfide bondi35 ↔ 42PROSITE-ProRule annotation
Disulfide bondi44 ↔ 63PROSITE-ProRule annotation
Disulfide bondi73 ↔ 92PROSITE-ProRule annotation
Disulfide bondi103 ↔ 110PROSITE-ProRule annotation
Disulfide bondi112 ↔ 131PROSITE-ProRule annotation
Disulfide bondi138 ↔ 159PROSITE-ProRule annotation
Disulfide bondi170 ↔ 177PROSITE-ProRule annotation
Disulfide bondi179 ↔ 199PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP81439
SMRiP81439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini70 – 131Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST62
Domaini135 – 199Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

CDDicd00191 TY, 3 hits
Gene3Di4.10.800.10, 3 hits
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 3 hits
SMARTiView protein in SMART
SM00211 TY, 3 hits
SUPFAMiSSF57610 SSF57610, 3 hits
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 3 hits

Sequencei

Sequence statusi: Complete.

P81439-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLSKCQQLQA SANSGLIGAY VPQCKETGEF EEKQCWGSTG YCWCVDEDGK
60 70 80 90 100
EILGTKIRGS PDCSRRKAAL TLCQMMQAII VNVPGWCGPP SCKADGSFDE
110 120 130 140 150
VQCCASNGEC YCVDKKGKEL EGTRQKGRPS CERHLSPCEE ARLQAHSNSL
160 170 180 190
RVGMFVPQCL EDGSYNPVQC WPSTGYCWCV DEGGVKVPGS DVRFKRPTC
Length:199
Mass (Da):21,755
Last modified:December 15, 1998 - v1
Checksum:i87E44735F8171BFC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti3S → T. 1
Natural varianti42C → V. 1
Natural varianti130S → T. 1
Natural varianti137P → E. 1
Natural varianti143 – 144LQ → IK. 2
Natural varianti156V → L. 1
Natural varianti184G → D. 1

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP81439
SMRiP81439
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI31.003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00191 TY, 3 hits
Gene3Di4.10.800.10, 3 hits
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 3 hits
SMARTiView protein in SMART
SM00211 TY, 3 hits
SUPFAMiSSF57610 SSF57610, 3 hits
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEQST_ACTEQ
AccessioniPrimary (citable) accession number: P81439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: December 20, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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