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Protein

Alcohol dehydrogenase class-3

Gene
N/A
Organism
Octopus vulgaris (Common octopus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi69Zinc 1; catalytic1
Metal bindingi99Zinc 21
Metal bindingi102Zinc 21
Metal bindingi105Zinc 21
Metal bindingi113Zinc 21
Sitei117Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi176Zinc 1; catalytic1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
OrganismiOctopus vulgaris (Common octopus)
Taxonomic identifieri6645 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeOctopus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607681 – 378Alcohol dehydrogenase class-3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP81431

PTM databases

iPTMnetiP81431

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP81431
SMRiP81431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P81431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TDATGKPIKC MAAIAWEAKK PLSIEEVEVA PPKSGEVRIK ILHSGVCHTD
60 70 80 90 100
AYTLEGIDPE GIFPVILGHE GAGIVESIGE GVTSVKPGDT VIPLYVPQCY
110 120 130 140 150
ECKFCLNPKT NLCQKIRVTQ GKGVMPDGTT RFTCKGKEVF HFMGCSTFSE
160 170 180 190 200
FTVVAEISIA KVNPKAALDK VCLLGCGIST GYGAALNTAA VEKGSNCAVW
210 220 230 240 250
GLGAVGLAVA MGCKAAGAAR IIGIDINESK FEIGKKFGIT EFVNPKKFCK
260 270 280 290 300
SVQKVLGEMT DVGVDFTFEC IGNVGVMRAA LESCHKGWGT SVIVGVAAHG
310 320 330 340 350
EEISTRPFQL VTGRVWKGTA FGGFKSRDSV PKLVDDYMNK KLLLDEFVSH
360 370
KLSFKKINEA FDLMHKGESI RAVLDIPE
Length:378
Mass (Da):40,400
Last modified:December 15, 1998 - v1
Checksum:iB19CDA25C1261ACA
GO

Sequence databases

PIRiA49662

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA49662

3D structure databases

ProteinModelPortaliP81431
SMRiP81431
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP81431

Proteomic databases

PRIDEiP81431

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHX_OCTVU
AccessioniPrimary (citable) accession number: P81431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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