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Entry version 146 (17 Jun 2020)
Sequence version 2 (20 Apr 2010)
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Protein

Protein FAM189B

Gene

FAM189B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM189B
Alternative name(s):
Protein COTE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM189B
Synonyms:C1orf2, COTE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160767.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1233 FAM189B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P81408

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10712

Open Targets

More...
OpenTargetsi
ENSG00000160767

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25608

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P81408 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM189B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792611 – 668Protein FAM189BAdd BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P81408

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P81408

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P81408

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P81408

PeptideAtlas

More...
PeptideAtlasi
P81408

PRoteomics IDEntifications database

More...
PRIDEi
P81408

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3358
57695 [P81408-1]
57696 [P81408-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P81408

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P81408

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160767 Expressed in dorsal root ganglion and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P81408 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P81408 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160767 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with WWOX.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115938, 104 interactors

Protein interaction database and analysis system

More...
IntActi
P81408, 74 interactors

Molecular INTeraction database

More...
MINTi
P81408

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354958

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P81408 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi243 – 249Poly-Pro7
Compositional biasi634 – 638Poly-Ser5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM189 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IET7 Eukaryota
ENOG410YD59 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025607_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P81408

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHRSLGD

Database of Orthologous Groups

More...
OrthoDBi
608892at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P81408

TreeFam database of animal gene trees

More...
TreeFami
TF332736

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007237 CD20-like
IPR030431 FAM189

The PANTHER Classification System

More...
PANTHERi
PTHR17615 PTHR17615, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P81408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT
60 70 80 90 100
FSMVASSVTT TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL
110 120 130 140 150
LSVLCVMLSM AGSVLSCKNA QLARDFQQCS LEGKVCVCCP SVPLLRPCPE
160 170 180 190 200
SGQELKVAPN STCDEARGAL KNLLFSVCGL TICAAIICTL SAIVCCIQIF
210 220 230 240 250
SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE FVPPVPPPPY
260 270 280 290 300
YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT
310 320 330 340 350
LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL
360 370 380 390 400
ELQGSVRSVD YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR
410 420 430 440 450
SYSCSAPEAP PPLGAPTAAR SCHRLEGWPP WVGPCFPELR RRVPRGGGRP
460 470 480 490 500
AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP ASPPPLLLPR SHSDPGITTS
510 520 530 540 550
SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC PSPKLLRARS
560 570 580 590 600
AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD
610 620 630 640 650
PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER
660
GTRPHSLSLN GGSRETGL
Length:668
Mass (Da):71,355
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE22EED90923826BD
GO
Isoform B (identifier: P81408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-171: Missing.

Show »
Length:572
Mass (Da):61,135
Checksum:i103AAACFCBD20DF3
GO
Isoform 2 (identifier: P81408-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-94: Missing.
     207-207: T → TQ

Show »
Length:650
Mass (Da):69,425
Checksum:iC852AD556C0848D0
GO
Isoform 3 (identifier: P81408-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: T → TQ

Show »
Length:669
Mass (Da):71,483
Checksum:iE30360AC9A4571E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96AD8Q96AD8_HUMAN
C1orf2 protein
FAM189B C1orf2, hCG_16120
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q96H71Q96H71_HUMAN
C1orf2 protein
FAM189B
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD59D6RD59_HUMAN
Protein FAM189B
FAM189B
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035684358S → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037876549R → H. Corresponds to variant dbSNP:rs2072648Ensembl.1
Natural variantiVAR_056842646R → H. Corresponds to variant dbSNP:rs2072648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03892676 – 171Missing in isoform B. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_04672876 – 94Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_046729207T → TQ in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF023268 Genomic DNA Translation: AAC51822.1
AL713999 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53094.1
CH471121 Genomic DNA Translation: EAW53097.1
CH471121 Genomic DNA Translation: EAW53098.1
BC040136 mRNA Translation: AAH40136.2
BC006493 mRNA Translation: AAH06493.1
BC007444 mRNA Translation: AAH07444.1
BC010471 mRNA Translation: AAH10471.1
BC033707 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1103.1 [P81408-1]
CCDS1104.1 [P81408-2]
CCDS58035.1 [P81408-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08827

NCBI Reference Sequences

More...
RefSeqi
NP_001254537.1, NM_001267608.1 [P81408-3]
NP_006580.2, NM_006589.2 [P81408-1]
NP_937995.1, NM_198264.1 [P81408-2]
XP_005244902.1, XM_005244845.1 [P81408-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000350210; ENSP00000307128; ENSG00000160767 [P81408-2]
ENST00000361361; ENSP00000354958; ENSG00000160767 [P81408-1]
ENST00000368368; ENSP00000357352; ENSG00000160767 [P81408-3]
ENST00000572488; ENSP00000458501; ENSG00000262666 [P81408-3]
ENST00000574749; ENSP00000460960; ENSG00000262666 [P81408-2]
ENST00000575430; ENSP00000461152; ENSG00000262666 [P81408-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10712

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10712

UCSC genome browser

More...
UCSCi
uc001fjm.4 human [P81408-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023268 Genomic DNA Translation: AAC51822.1
AL713999 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53094.1
CH471121 Genomic DNA Translation: EAW53097.1
CH471121 Genomic DNA Translation: EAW53098.1
BC040136 mRNA Translation: AAH40136.2
BC006493 mRNA Translation: AAH06493.1
BC007444 mRNA Translation: AAH07444.1
BC010471 mRNA Translation: AAH10471.1
BC033707 mRNA No translation available.
CCDSiCCDS1103.1 [P81408-1]
CCDS1104.1 [P81408-2]
CCDS58035.1 [P81408-3]
PIRiT08827
RefSeqiNP_001254537.1, NM_001267608.1 [P81408-3]
NP_006580.2, NM_006589.2 [P81408-1]
NP_937995.1, NM_198264.1 [P81408-2]
XP_005244902.1, XM_005244845.1 [P81408-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115938, 104 interactors
IntActiP81408, 74 interactors
MINTiP81408
STRINGi9606.ENSP00000354958

PTM databases

iPTMnetiP81408
PhosphoSitePlusiP81408

Polymorphism and mutation databases

BioMutaiFAM189B
DMDMi294862432

Proteomic databases

jPOSTiP81408
MassIVEiP81408
MaxQBiP81408
PaxDbiP81408
PeptideAtlasiP81408
PRIDEiP81408
ProteomicsDBi3358
57695 [P81408-1]
57696 [P81408-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1675 77 antibodies

The DNASU plasmid repository

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DNASUi
10712

Genome annotation databases

EnsembliENST00000350210; ENSP00000307128; ENSG00000160767 [P81408-2]
ENST00000361361; ENSP00000354958; ENSG00000160767 [P81408-1]
ENST00000368368; ENSP00000357352; ENSG00000160767 [P81408-3]
ENST00000572488; ENSP00000458501; ENSG00000262666 [P81408-3]
ENST00000574749; ENSP00000460960; ENSG00000262666 [P81408-2]
ENST00000575430; ENSP00000461152; ENSG00000262666 [P81408-1]
GeneIDi10712
KEGGihsa:10712
UCSCiuc001fjm.4 human [P81408-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10712
DisGeNETi10712
EuPathDBiHostDB:ENSG00000160767.20

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM189B
HGNCiHGNC:1233 FAM189B
HPAiENSG00000160767 Low tissue specificity
neXtProtiNX_P81408
OpenTargetsiENSG00000160767
PharmGKBiPA25608

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IET7 Eukaryota
ENOG410YD59 LUCA
GeneTreeiENSGT00530000063335
HOGENOMiCLU_025607_0_0_1
InParanoidiP81408
OMAiCHRSLGD
OrthoDBi608892at2759
PhylomeDBiP81408
TreeFamiTF332736

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10712 11 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM189B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10712
PharosiP81408 Tbio

Protein Ontology

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PROi
PR:P81408
RNActiP81408 protein

Gene expression databases

BgeeiENSG00000160767 Expressed in dorsal root ganglion and 233 other tissues
ExpressionAtlasiP81408 baseline and differential
GenevisibleiP81408 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030431 FAM189
PANTHERiPTHR17615 PTHR17615, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF189B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81408
Secondary accession number(s): B1AVS5, Q8IXL3, Q9BR66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 20, 2010
Last modified: June 17, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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