UniProtKB - P81406 (GAPN_PEA)
Protein
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene
GAPN
Organism
Pisum sativum (Garden pea)
Status
Functioni
Important as a means of generating NADPH for biosynthetic reactions.1 Publication
Catalytic activityi
- EC:1.2.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 | |
Sitei | 169 | Transition state stabilizerBy similarity | 1 | |
Binding sitei | 192 | NADPBy similarity | 1 | |
Binding sitei | 195 | NADPBy similarity | 1 | |
Binding sitei | 230 | NADPBy similarity | 1 | |
Active sitei | 264 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 298 | Nucleophile | 1 | |
Binding sitei | 391 | NADPBy similarity | 1 | |
Binding sitei | 451 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 245 – 249 | NADBy similarity | 5 |
GO - Molecular functioni
- glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
SABIO-RKi | P81406 |
Names & Taxonomyi
Protein namesi | Recommended name: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.9)Alternative name(s): Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)] Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase Triosephosphate dehydrogenase |
Gene namesi | Name:GAPN |
Organismi | Pisum sativum (Garden pea) |
Taxonomic identifieri | 3888 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › Hologalegina › IRL clade › Fabeae › Pisum |
Subcellular locationi
Other locations
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056578 | 1 – 496 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenaseAdd BLAST | 496 |
Proteomic databases
PRIDEi | P81406 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 169 – 170 | Substrate bindingBy similarity | 2 | |
Regioni | 297 – 299 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
P81406-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATGVLAEI IDGDVYKYYA DGEWKKSTSG KSVAIINPTT RKPQYKVQAC
60 70 80 90 100
SQEEVNKVMD SAKSAQKSWA KTPLWKRAEL LHKAAAILKE HKAAIAECLV
110 120 130 140 150
KEIAKPAKDA VTEVVRSGDL VSYCAEEGVR ILGEGKFLVS DSFPGNERTK
160 170 180 190 200
YCLTSKIPLG VILAIPPFNY PVNLAVSKIA PALIAGNSIV LKPPTQGAVA
210 220 230 240 250
ALHMVHCFHL AGFPKGLISC VTGKGSEIGD FLTMHPGVNC ISFTGGDTGI
260 270 280 290 300
AISKKSGMIP LQMELGGKDA CIVLEDADLD LVAANIIKGG FSYSGQRCTA
310 320 330 340 350
VKVVLVMESV ADALVEKVKV KVAKLSVGPP EDDSDITPVV SESSANFIEG
360 370 380 390 400
LVNDAKEKGA TFCQEYKREG NLIWPLLLDN VRPDMRIAWE EPFGPVLPVI
410 420 430 440 450
RINSVEEGIH HCNASNFGLQ GCVFTKDINK AIMISDAMES GTVQINSAPA
460 470 480 490
RGPDHFPFQG IKDSGIGSQG ITNSINMMTK VKTTVINLPS PSYTMG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34988 Genomic DNA Translation: AAO38512.1 X75327 mRNA Translation: CAA53076.1 |
PIRi | S43832 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U34988 Genomic DNA Translation: AAO38512.1 X75327 mRNA Translation: CAA53076.1 |
PIRi | S43832 |
3D structure databases
SMRi | P81406 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P81406 |
Enzyme and pathway databases
SABIO-RKi | P81406 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GAPN_PEA | |
Accessioni | P81406Primary (citable) accession number: P81406 Secondary accession number(s): Q53WX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | December 11, 2019 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families