Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P81299 (CDC14_CAEEL)

Entry version 161 (07 Apr 2021)
Sequence version 3 (12 Sep 2018)
Previous versions | rss
Add a publicationFeedback
Protein

Tyrosine-protein phosphatase cdc-14

Gene

cdc-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal (PubMed:15247923, PubMed:21723944). Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development (PubMed:15247923). Has been shown to not be required for cytokinesis (PubMed:15247923). However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and may be required for localization of the spindle component zen-4, and its interacting partner air-2 at the spindle during late cell divisions (PubMed:12213836).3 Publications
Main regulator of cell cycle arrest in vulval precursor cells.1 Publication

Caution

Has been shown in one report to not be localized to centrosomes or nuclei, and based on RNAi-mediated knockdown studies, has been shown to play a role in cytokinesis (PubMed:12213836). However, has also been reported to localize to centrosomes and nuclei and to have no role in cytokinesis, based on results obtained using the cdc-14 he118 mutant and RNAi-mediated knockdown (PubMed:15247923).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sodium orthovanadate. Weakly inhibited by sodium fluoride and okadaic acid.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei295Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-CEL-5687128, MAPK6/MAPK4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase cdc-14 (EC:3.1.3.48PROSITE-ProRule annotation1 Publication)
Alternative name(s):
Cell division cycle-related protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdc-142 PublicationsImported
ORF Names:C17G10.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...WormBasei		C17G10.4a ; CE30868 ; WBGene00000383 ; cdc-14
C17G10.4c ; CE08288 ; WBGene00000383 ; cdc-14
C17G10.4d ; CE06845 ; WBGene00000383 ; cdc-14
C17G10.4e ; CE36916 ; WBGene00000383 ; cdc-14
C17G10.4g ; CE50122 ; WBGene00000383 ; cdc-14
C17G10.4h ; CE01789 ; WBGene00000383 ; cdc-14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in extra cell divisions in the vulval lineage, but does not result in defects in cytokinesis (PubMed:15247923, PubMed:21723944). RNAi-mediated knockdown decreases cki-1 expression in the nucleus of vulval precursor cells (PubMed:15247923). In contrasting studies RNAi-mediated knockdown results in embryonic lethality with the production of multinucleated embryos that exhibit cytokinesis failure during telophase, no central spindle formation, and failed localization of the spindle component zen-4 and its interacting partner air-2 at the spindle in either anaphase or telophase (PubMed:12213836).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi295C → S: Abolishes phosphatase activity. 1 Publication1
Mutagenesisi366 – 371KRNVRR → AANVAA: Disrupts nuclear localization. Localizes to the cytoplasm; when associated with 372-A--A-381. 1 Publication6
Mutagenesisi372 – 381LVNQVDDINL → AVNQVDDANA: Impairs nuclear export signal. Disrupts cytoplasmic localization, conferring nuclear localization during interphase. Localizes to the cytoplasm; when associated with 366-A--A-371. 1 Publication10
Mutagenesisi446 – 709Missing in he118; no effect on viability, embryogenesis or fertility. Disrupts cell cycle arrest of vulval precursor, intestinal, and hypodermal cells, and of precursor cells that give rise to male specific structures during postembryonic development. Vulval precursor cells undergo an extra round of cell division during the L2 larval stage of development, but the additional precursor cells do not disrupt formation of the vulval structure and animals undergo normal vulval morphogenesis during the L4 larval stage. Does not result in defects in cytokinesis. Overexpression of the cyclin dependent kinase inhibitor cki-1, or knockout with the G1/S-specific cyclin-E cye-1 (eh10), rescues the cell division phenotype. 1 PublicationAdd BLAST264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948801 – 709Tyrosine-protein phosphatase cdc-14Add BLAST709

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P81299

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P81299

PeptideAtlas

More...PeptideAtlasi		P81299

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P81299

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the soma during early embryogenesis, and widely expressed after hatching. Isoform C: Expressed in the soma during early embryogenesis, but after hatching, expression in larvae is restricted to V and P lineages, the postembryonic lineages that contribute to the seam cells and vulval precursor cells, respectively.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00000383, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		39287, 7 interactors

Database of interacting proteins

More...DIPi		DIP-25903N

STRING: functional protein association networks

More...STRINGi		6239.C17G10.4b.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P81299

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 354Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi366 – 371Nuclear localization signal1 Publication6
Motifi372 – 381Nuclear export signal1 Publication10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1720, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000170847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_288890_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P81299

Identification of Orthologs from Complete Genome Data

More...OMAi		CANGKSY

Database of Orthologous Groups

More...OrthoDBi		1357618at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd14499, CDC14_C, 1 hit
cd17657, CDC14_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026070, CDC14
IPR044506, CDC14_C
IPR029260, DSPn
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom

The PANTHER Classification System

More...PANTHERi		PTHR23339:SF27, PTHR23339:SF27, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14671, DSPn, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00195, DSPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform hImported (identifier: P81299-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREDHSPRRN NTIENTLTEL LPNRLYFGCF PNPDAIDKSD KSVKKTCFIN 
        60         70         80         90        100
INNKFHYEPF YEDFGPWNLS VLYRLCVQVG KLLEVEEKRS RRVVLFCQDD 
       110        120        130        140        150
GTGQYDKIRV NTAYVLGAYL IIYQGFSADD AYLKVSSGET VKFVGFRDAS 
       160        170        180        190        200
MGSPQYLLHL HDVLRGIEKA LKFGWLDFSD FDYEEYEFYE RVENGDFNWI 
       210        220        230        240        250
IPGKILSFCG PHNESREENG YPYHAPDVYF DYFRENKVST IVRLNAKNYD 
       260        270        280        290        300
ASKFTKAGFD HVDLFFIDGS TPSDEIMLKF IKVVDNTKGG VAVHCKAGLG 
       310        320        330        340        350
RTGTLIACWM MKEYGLTAGE CMGWLRVCRP GSVIGPQQPY LIEKQKFCWS 
       360        370        380        390        400
LSQSNGVHLT QNKEEKRNVR RLVNQVDDIN LGEERISPKS RENTRPNILR 
       410        420        430        440        450
RRVQVQNGRS TAPVTIAPAG TSESRRSTKP SRVVDETALD DQGRSQGDRL 
       460        470        480        490        500
LQLKAKHQHE SETTSPNSSS SRRFVKSSTP QMTVPSQAYL NRNREPIIVT 
       510        520        530        540        550
PSKNGTSSGT SSRQLKTTPN GNVAYRTRNS SGNTTSTLTR TGNESYRFHN 
       560        570        580        590        600
SLFYEPASAV FPSMASRRSE TTRYLSPTTP IKPMSPSYTD GTSPRYKARL 
       610        620        630        640        650
RSENPIGSTT STPFSLQPQI TKCSLTAESK PPKRILSMPG TSKSTSSLKK 
       660        670        680        690        700
IQVSRPRPYP STGVRVELCA NGKSYDIRPR KEAHVIPGAG LAANTEALLG 

VCKLVNTLS
Length:709
Mass (Da):79,740
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB5873D8C7FEDB0C
GO
Isoform aImported (identifier: P81299-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-555: Missing.
     701-708: VCKLVNTL → KRRKTA

Show »
Length:693
Mass (Da):77,865
Checksum:i9013D05AD9FB560D
GO
Isoform cImported (identifier: P81299-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-555: Missing.
     620-709: ITKCSLTAES...GVCKLVNTLS → FGLVRVPPDS...MYMTRSCERK

Show »
Length:681
Mass (Da):76,698
Checksum:i2C056CD6FA03ADDC
GO
Isoform dImported (identifier: P81299-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-555: Missing.

Show »
Length:695
Mass (Da):77,995
Checksum:iE834240A433EDED1
GO
Isoform eImported (identifier: P81299-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-708: VCKLVNTL → KRRKTA

Show »
Length:707
Mass (Da):79,610
Checksum:iE7C1549ADC2625C3
GO
Isoform gImported (identifier: P81299-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-695: ITKCSLTAES...IPGAGLAANT → FGLVRVPPDS...MYMTRSCERK
     696-709: Missing.

Show »
Length:695
Mass (Da):78,443
Checksum:iC7EE56E4DE7AE7F4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT74543 differs from that shown.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059807542 – 555Missing in isoform a, isoform c and isoform d. CuratedAdd BLAST14
Alternative sequenceiVSP_059808620 – 709ITKCS…VNTLS → FGLVRVPPDSPHSIMAHRPP PTTSSRAPLSPHNYSTTQGY STSSRGLYGDKKPLARGSVS TSTLPSMYMTRSCERK in isoform c. CuratedAdd BLAST90
Alternative sequenceiVSP_059809620 – 695ITKCS…LAANT → FGLVRVPPDSPHSIMAHRPP PTTSSRAPLSPHNYSTTQGY STSSRGLYGDKKPLARGSVS TSTLPSMYMTRSCERK in isoform g. CuratedAdd BLAST76
Alternative sequenceiVSP_059810696 – 709Missing in isoform g. CuratedAdd BLAST14
Alternative sequenceiVSP_059811701 – 708VCKLVNTL → KRRKTA in isoform a and isoform e. Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY661743 mRNA Translation: AAT74542.1
AY661744 mRNA Translation: AAT74543.1 Sequence problems.
AY661745 mRNA Translation: AAT74544.1
AY661746 mRNA Translation: AAT74545.1
AY661747 mRNA Translation: AAT74546.1
AF000363 mRNA Translation: AAB94407.1
BX284602 Genomic DNA Translation: CCD64951.1
BX284602 Genomic DNA Translation: CCD64953.1
BX284602 Genomic DNA Translation: CCD64954.1
BX284602 Genomic DNA Translation: CCD64955.1
BX284602 Genomic DNA Translation: CTQ86448.1
BX284602 Genomic DNA Translation: CTQ86449.1

Protein sequence database of the Protein Information Resource

More...PIRi		E88158
T34097

NCBI Reference Sequences

More...RefSeqi		NP_001021969.1, NM_001026798.5 [P81299-5]
NP_001300509.1, NM_001313580.1
NP_001300510.1, NM_001313581.1 [P81299-1]
NP_495085.2, NM_062684.5
NP_495086.1, NM_062685.3
NP_740991.1, NM_170993.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		C17G10.4a.1; C17G10.4a.1; WBGene00000383 [P81299-2]
C17G10.4a.2; C17G10.4a.2; WBGene00000383 [P81299-2]
C17G10.4c.1; C17G10.4c.1; WBGene00000383 [P81299-3]
C17G10.4c.2; C17G10.4c.2; WBGene00000383 [P81299-3]
C17G10.4d.1; C17G10.4d.1; WBGene00000383 [P81299-4]
C17G10.4e.1; C17G10.4e.1; WBGene00000383 [P81299-5]
C17G10.4e.2; C17G10.4e.2; WBGene00000383 [P81299-5]
C17G10.4g.1; C17G10.4g.1; WBGene00000383 [P81299-7]
C17G10.4h.1; C17G10.4h.1; WBGene00000383 [P81299-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		173945

UCSC genome browser

More...UCSCi		C17G10.4b, c. elegans [P81299-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY661743 mRNA Translation: AAT74542.1
AY661744 mRNA Translation: AAT74543.1 Sequence problems.
AY661745 mRNA Translation: AAT74544.1
AY661746 mRNA Translation: AAT74545.1
AY661747 mRNA Translation: AAT74546.1
AF000363 mRNA Translation: AAB94407.1
BX284602 Genomic DNA Translation: CCD64951.1
BX284602 Genomic DNA Translation: CCD64953.1
BX284602 Genomic DNA Translation: CCD64954.1
BX284602 Genomic DNA Translation: CCD64955.1
BX284602 Genomic DNA Translation: CTQ86448.1
BX284602 Genomic DNA Translation: CTQ86449.1
PIRiE88158
T34097
RefSeqiNP_001021969.1, NM_001026798.5 [P81299-5]
NP_001300509.1, NM_001313580.1
NP_001300510.1, NM_001313581.1 [P81299-1]
NP_495085.2, NM_062684.5
NP_495086.1, NM_062685.3
NP_740991.1, NM_170993.4

3D structure databases

SMRiP81299
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi39287, 7 interactors
DIPiDIP-25903N
STRINGi6239.C17G10.4b.2

PTM databases

iPTMnetiP81299

Proteomic databases

EPDiP81299
PaxDbiP81299
PeptideAtlasiP81299

Genome annotation databases

EnsemblMetazoaiC17G10.4a.1; C17G10.4a.1; WBGene00000383 [P81299-2]
C17G10.4a.2; C17G10.4a.2; WBGene00000383 [P81299-2]
C17G10.4c.1; C17G10.4c.1; WBGene00000383 [P81299-3]
C17G10.4c.2; C17G10.4c.2; WBGene00000383 [P81299-3]
C17G10.4d.1; C17G10.4d.1; WBGene00000383 [P81299-4]
C17G10.4e.1; C17G10.4e.1; WBGene00000383 [P81299-5]
C17G10.4e.2; C17G10.4e.2; WBGene00000383 [P81299-5]
C17G10.4g.1; C17G10.4g.1; WBGene00000383 [P81299-7]
C17G10.4h.1; C17G10.4h.1; WBGene00000383 [P81299-1]
GeneIDi173945
UCSCiC17G10.4b, c. elegans [P81299-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		173945
WormBaseiC17G10.4a ; CE30868 ; WBGene00000383 ; cdc-14
C17G10.4c ; CE08288 ; WBGene00000383 ; cdc-14
C17G10.4d ; CE06845 ; WBGene00000383 ; cdc-14
C17G10.4e ; CE36916 ; WBGene00000383 ; cdc-14
C17G10.4g ; CE50122 ; WBGene00000383 ; cdc-14
C17G10.4h ; CE01789 ; WBGene00000383 ; cdc-14

Phylogenomic databases

eggNOGiKOG1720, Eukaryota
GeneTreeiENSGT00940000170847
HOGENOMiCLU_288890_0_0_1
InParanoidiP81299
OMAiCANGKSY
OrthoDBi1357618at2759

Enzyme and pathway databases

ReactomeiR-CEL-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-CEL-5687128, MAPK6/MAPK4 signaling

Miscellaneous databases

Protein Ontology

More...PROi		PR:P81299

Gene expression databases

BgeeiWBGene00000383, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

CDDicd14499, CDC14_C, 1 hit
cd17657, CDC14_N, 1 hit
Gene3Di3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR026070, CDC14
IPR044506, CDC14_C
IPR029260, DSPn
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR000387, TYR_PHOSPHATASE_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR23339:SF27, PTHR23339:SF27, 1 hit
PfamiView protein in Pfam
PF14671, DSPn, 1 hit
SMARTiView protein in SMART
SM00195, DSPc, 1 hit
SUPFAMiSSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC14_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81299
Secondary accession number(s): A0A0K3AQY3
, A0A0K3ATW0, P81300, Q09955, Q09976, Q6DLY2, Q6DLY3, Q6DLY4, Q6DLY5, Q6DLY6, Q8MQD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 12, 2018
Last modified: April 7, 2021
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again