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Entry version 152 (07 Apr 2021)
Sequence version 2 (26 Sep 2001)
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Protein

Versican core protein

Gene

VCAN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name:
GHAP
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCAN
Synonyms:CSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:36778, VCAN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752121 – 3381Versican core proteinAdd BLAST3361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 131By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 244By similarity
Disulfide bondi197 ↔ 218By similarity
Disulfide bondi271 ↔ 346By similarity
Disulfide bondi295 ↔ 316By similarity
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1653N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1974N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2074N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2103N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2109PhosphoserineBy similarity1
Glycosylationi2263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2356N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2607PhosphoserineBy similarity1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2612PhosphothreonineBy similarity1
Glycosylationi2623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2641N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2919N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3052N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3078 ↔ 3089By similarity
Disulfide bondi3083 ↔ 3098By similarity
Disulfide bondi3100 ↔ 3109By similarity
Disulfide bondi3116 ↔ 3127By similarity
Disulfide bondi3121 ↔ 3136By similarity
Disulfide bondi3138 ↔ 3147By similarity
Disulfide bondi3154 ↔ 3165By similarity
Disulfide bondi3182 ↔ 3274By similarity
Disulfide bondi3250 ↔ 3266By similarity
Disulfide bondi3281 ↔ 3324By similarity
Disulfide bondi3310 ↔ 3337By similarity
Glycosylationi3354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3364N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1423 – 1424Cleavage; by ADAMTS15By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P81282

PeptideAtlas

More...
PeptideAtlasi
P81282

PRoteomics IDEntifications database

More...
PRIDEi
P81282

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cerebral white matter. Isoform V0 and isoform V1 are expressed in the central nervous system, and in a number of mesenchymal and epithelial tissues; the major isoform V2 is restricted to the central nervous system.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Disappears after the cartilage development.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P81282, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000019848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P81282

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 147Ig-like V-typeAdd BLAST127
Domaini151 – 246Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini252 – 348Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3074 – 3110EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3112 – 3148EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3161 – 3275C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3279 – 3339SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 1336GAG-alpha (glucosaminoglycan attachment domain)Add BLAST988
Regioni1337 – 3074GAG-betaAdd BLAST1738

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRBE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156102

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P81282

Database of Orthologous Groups

More...
OrthoDBi
74642at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform V0 (identifier: P81282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLINIKSILW MCSTLIAAHA LQKVNMEKSP PVKGSLSGKV NLPCHFSTMP
60 70 80 90 100
TLPPSYNTTS EFLRIKWSKI ELDKTGKDLK ETTVLVAQNG NIKIGQDYKG
110 120 130 140 150
RVSVPTHPED VGDASLTMVK LLASDAGRYR CDVMYGIEDT QDTVSLTVEG
160 170 180 190 200
VVFHYRAATS RYTLNFEMAQ KACVDIGAVI ATPEQLHAAY EDGFEQCDAG
210 220 230 240 250
WLSDQTVRYP IRVPREGCYG DMMGKEGVRT YGFRAPHETY DVYCYVDHLD
260 270 280 290 300
GDVFHITAPN KFTFEEAGEE CKTQDARLAT VGELQAAWRN GFDRCDYGWL
310 320 330 340 350
LDASVRHPVT VARAQCGGGL LGVRTLYRFE NQTGFPTPDS RFDAYCFKPK
360 370 380 390 400
QNISEATTIE LNMLAETVSP TLLEELQVGL DRMTPIVPLI TELPVITTKV
410 420 430 440 450
PPIGNIVNFE QKSTVQPLTS THRSATESLP PDGSMKKPWD MDYYSPSASG
460 470 480 490 500
PLGEPDVSEI KEEVPQSTTV VSHHAPDSWD GVKEDLQIKD SVTQIEQIEV
510 520 530 540 550
GPLVTSMEIS KHIPSKEFTV TVTPFVSTTM TLESKTEKKA ISTVSESVTT
560 570 580 590 600
SHYGFTLREG DGEDRISTVR SGQSTSIFSQ IPEVITVSKT SEDTTRGQLE
610 620 630 640 650
DVESVSASTI VSPDSDGSPM DHRQEKQTHG RITEGFLGQY VSTTPFPSQH
660 670 680 690 700
HTEVELFPYS GDKRLVEGTS TVISPTPRTG RERTETLRPA MRTVTYTNDE
710 720 730 740 750
IQEKITKDSS IEKIEEEGFS GMKFPTASPE QIHHTKYSVG MTKSFESPAL
760 770 780 790 800
MTTTKPGVTP TEATDVEEDF TTPSGLETDG YQDTTEYEEG ITTVHLIQST
810 820 830 840 850
LNVEVVTVSK WSLDEDNTTS KPLGSTEHVG SPKLPPALIT TTGVSGKDKE
860 870 880 890 900
MPSLTEDGRD EFTRIPGSTQ RPLEEFTEED TTDHEKFTVR FQPTTSIATT
910 920 930 940 950
EKSTLRDSIT EERVPPFTST EVRVTHATIE GSALDEGEDV DVSKPLSTVP
960 970 980 990 1000
QFAHPSDVEG STFVNYSSTQ EPTTYVDTSH TIPLPVIPKT EWGVLVPSIP
1010 1020 1030 1040 1050
SEGEVLGEPS QDIRVINQTH FEASMYPETV RTTTEITQEA TREDFLWKEQ
1060 1070 1080 1090 1100
TPEKPVSPPS STTDTAKETT PPLDEQESDG SAYTVFEDRS VMGSDRVSVL
1110 1120 1130 1140 1150
VTTPIGKFEQ HTSFPPGAVT KAKTDEVVTL TPTTGSKVTF SPWPKQKYET
1160 1170 1180 1190 1200
EGTSPRGFVS PFSIGVTQLI EETTTEKREK TSLDYIDLGS GLFEKPKATE
1210 1220 1230 1240 1250
LPEFSTVKAT VPSDTAAFSS ADRLHTPSAS TEKPPLIDRE PDEETTSDMV
1260 1270 1280 1290 1300
IIGESTSRVP PTTLEDIVAK KTETDIDREY FTTSSTSTTQ PTRPPTVEGK
1310 1320 1330 1340 1350
EAFGPQAFST PEPPAGTKFH PDINVYIIEV RENKTGRMSD FSVSGHPIDS
1360 1370 1380 1390 1400
ESKEDEPCSE ETDPEHDLIA EILPELLGML HSEEDEEDEE CANATDVTTT
1410 1420 1430 1440 1450
PSVQYINGKH VVTTVPKDPE AAEARRGQFE SVAPSQNFSD SSESDSHQFI
1460 1470 1480 1490 1500
ITHAGLPTAM QPNESKETTE SLEITWRPEI YPETAEPFSS GEPDIFPTAS
1510 1520 1530 1540 1550
IHEGEATEGP DSITEKNPEL DHLVHEHAES VPLFPEESSG DAAIDQESQK
1560 1570 1580 1590 1600
IIFSGATEGT FGEEAEKSST THTPSMVASS VSAPVSEDAS FILTGTPQSD
1610 1620 1630 1640 1650
EPLSTVESWV EITPRHTVEF SGSPSIPIPE GSGEAEEDKD KIFAMITDLS
1660 1670 1680 1690 1700
QRNTTDPRVT SDTSKIMITE SLVDVPTTTI YSISEQVSAV VPTKFVRETD
1710 1720 1730 1740 1750
TYEWVFSPPL EETTRKEEEK GTTGTASTVE VHSPTQRLDQ FVSPSELESS
1760 1770 1780 1790 1800
SETPPDDSAA ATRKSFTSQM TPTQSERETT SSTVVFKETE VLDNLAAQTT
1810 1820 1830 1840 1850
DPSLSSQPGV LEVSPTVPGS PVSLFMEQGS GEAAVDPETT TVSSLSLNIE
1860 1870 1880 1890 1900
PEILAKEEAA GAWSPNVETV FPFEPTEQVL STAVDREVAE TISQTSKENL
1910 1920 1930 1940 1950
VSEISGEPTH RAEIKGFSTD FPLEEDFSGD FREYSTVSYP ITKEEIVMME
1960 1970 1980 1990 2000
GSGDAAFKDT QMLPSVTPTS DLSNHTADSE EPGSTLVSTS AFPWEEFTAS
2010 2020 2030 2040 2050
AEGSGEPLLS VSSSVDQVFP SAAGKASGTD SPFIDQRLGE EGAINETDQR
2060 2070 2080 2090 2100
STILPTAEAE STKASTEEGE VKENHTVSMD FPPTVEPDEL WPRQEVNPVR
2110 2120 2130 2140 2150
QGNGSEIVSE EKTQEQESFE PLQSSVAPEQ TTFDSQTFPE PGLQTTGYFT
2160 2170 2180 2190 2200
LTTKKTYSTD ERMEEEVISL ADVSTPTLDS KGLVLYTTLP EVTEKSHFFL
2210 2220 2230 2240 2250
ATASVTESVP AESVIAGSTI KEEESIKPFP KVTSPIIKES DTDLIFSGLG
2260 2270 2280 2290 2300
SGEEVLPTLG SVNFTEIEQV LSTLYPLTSQ VQSLEASILN DTSGDYEGME
2310 2320 2330 2340 2350
NVANEMRPLI SKTDSIFEDG ETASSTTLPE ILSDARTEGP FTAPLTFSTG
2360 2370 2380 2390 2400
PGQPQNQTHR RAEEIQTSRP QPLTDQVSSE NSVTAETKET ATPATDFLAR
2410 2420 2430 2440 2450
TYDLEMAKGF VTPTPKPSDL FYEHSGEGSG ELDAVGAEVH ASGMTQATRQ
2460 2470 2480 2490 2500
GSTTFVSDRS LEKHPKVPSV EAVTVNGFPT VSMVLPLHPE QREGSPEATG
2510 2520 2530 2540 2550
TPASTASYEK ATEGAADSFQ DHFWGFKDST LKPDKRKATE SIIIDLDKED
2560 2570 2580 2590 2600
KDLILTMTES TILEIIPELT SDKNTVIDID HTKPIYEDIL GMQTDLDPEV
2610 2620 2630 2640 2650
PSGPPDSSEE STQVQEKYEA AVNLSSTEEN FEASGDILLA NYTQATPESK
2660 2670 2680 2690 2700
APEDRNPLDH TDFIFTTGIP ILSSETELDV LLPTATSLPI PSKSATVNPE
2710 2720 2730 2740 2750
SKTEAKTLED IFESSTLSDG QAIADQSEVI STLGYLERTQ NEDEAKKYVS
2760 2770 2780 2790 2800
PSFQPEFSSG AEEALTDPTP YVSIGTTYLT AQSLTEAPDV MEGARLPDSI
2810 2820 2830 2840 2850
DTSTVSAFSE LLSQTPSFPP LSIHLGSGDS EHSEDLQPSA LPSTDASTPP
2860 2870 2880 2890 2900
VSSGELANIE ATFKPSSEED FYITEPPSLP PDTEPSEDES KPKLLEPTEA
2910 2920 2930 2940 2950
SATELIAQEE IEIFQNSDNT TSVQVSGEAV KVFPSIETPE AEAIVTAASE
2960 2970 2980 2990 3000
TKLEGATLRP HSTSASVIHG VEAGVVPQPS PQTSERPTIL SPLEISPETQ
3010 3020 3030 3040 3050
AALIRGEDST VAAPKQQVPT RMLDSNKQAT LSTTELNTEL ATPSFPLLET
3060 3070 3080 3090 3100
SNETSFLIGI NEESVEGTAV YLPGPDRCKM NPCLNGGTCY PTETSYVCTC
3110 3120 3130 3140 3150
VPGYSGDRCE LDFDECHSNP CRNGATCIDG FNTFRCLCLP SYVGALCEQD
3160 3170 3180 3190 3200
TETCDYGWHK FQGQCYKYFA HRRTWDAAER ECRLQGAHLT SILSHEEQMF
3210 3220 3230 3240 3250
VNRVGHDYQW IGLNDKMFEH DFRWTDGSTL QYENWRPNQP DSFFSTGEDC
3260 3270 3280 3290 3300
VVIIWHENGQ WNDVPCNYHL TYTCKKGTVA CGQPPVVENA KTFGKMKPRY
3310 3320 3330 3340 3350
EINSLIRYHC KDGFIQRHLP TIRCLGNGRW AMPKITCLNP SAYQRTYSKK
3360 3370 3380
YFKNSSSAKD NSINTSKHDH RWSRRWQESR R
Length:3,381
Mass (Da):369,990
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF09716FA7778D459
GO
Isoform V1 (identifier: P81282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: P → R
     350-1336: Missing.

Show »
Length:2,394
Mass (Da):261,888
Checksum:iB82A3E10FC5BD990
GO
Isoform V2 (identifier: P81282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1337-3074: Missing.

Show »
Length:1,643
Mass (Da):182,895
Checksum:iA6F2BFC3A3DEF80A
GO
Isoform V3 (identifier: P81282-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: P → R
     350-3074: Missing.

Show »
Length:656
Mass (Da):74,793
Checksum:iF8FE153BD10C7AB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MZ85F1MZ85_BOVIN
Versican core protein
VCAN
3,371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M9P9A0A3Q1M9P9_BOVIN
Versican core protein
VCAN
3,381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1N6I5F1N6I5_BOVIN
Versican core protein
VCAN
2,394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1MZ83F1MZ83_BOVIN
Versican core protein
VCAN
1,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25Missing AA sequence (PubMed:1720020).Curated1
Sequence conflicti51Missing AA sequence (PubMed:1720020).Curated1
Sequence conflicti89N → D AA sequence (PubMed:1720020).Curated1
Sequence conflicti96Q → D AA sequence (PubMed:1720020).Curated1
Sequence conflicti346C → R AA sequence (PubMed:1720020).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003078349P → R in isoform V1 and isoform V3. 1 Publication1
Alternative sequenceiVSP_003081350 – 3074Missing in isoform V3. 1 PublicationAdd BLAST2725
Alternative sequenceiVSP_003079350 – 1336Missing in isoform V1. 1 PublicationAdd BLAST987
Alternative sequenceiVSP_0030801337 – 3074Missing in isoform V2. 1 PublicationAdd BLAST1738

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF060456 mRNA Translation: AAC24358.1
AF060457 mRNA Translation: AAC24359.1
AF060458 mRNA Translation: AAC24360.1
AF060459 mRNA Translation: AAC24361.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T14274
T42389

NCBI Reference Sequences

More...
RefSeqi
NP_851378.1, NM_181035.2 [P81282-1]
XP_015327844.1, XM_015472358.1 [P81282-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000042717; ENSBTAP00000040348; ENSBTAG00000014906 [P81282-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:282662

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060456 mRNA Translation: AAC24358.1
AF060457 mRNA Translation: AAC24359.1
AF060458 mRNA Translation: AAC24360.1
AF060459 mRNA Translation: AAC24361.1
PIRiT14274
T42389
RefSeqiNP_851378.1, NM_181035.2 [P81282-1]
XP_015327844.1, XM_015472358.1 [P81282-4]

3D structure databases

SMRiP81282
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019848

Proteomic databases

PaxDbiP81282
PeptideAtlasiP81282
PRIDEiP81282

Genome annotation databases

EnsembliENSBTAT00000042717; ENSBTAP00000040348; ENSBTAG00000014906 [P81282-4]
GeneIDi282662
KEGGibta:282662

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1462
VGNCiVGNC:36778, VCAN

Phylogenomic databases

eggNOGiENOG502QRBE, Eukaryota
GeneTreeiENSGT00940000156102
InParanoidiP81282
OrthoDBi74642at2759

Gene expression databases

ExpressionAtlasiP81282, baseline and differential

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81282
Secondary accession number(s): O77609
, O77610, O77611, O77612
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: April 7, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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