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UniProtKB - P81282 (CSPG2_BOVIN)

Entry version 152 (07 Apr 2021)
Sequence version 2 (26 Sep 2001)
Previous versions | rss
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Protein

Versican core protein

Gene

VCAN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name:
GHAP
Large fibroblast proteoglycan
PG-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCAN
Synonyms:CSPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:36778, VCAN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001752121 – 3381Versican core proteinAdd BLAST3361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 131By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 244By similarity
Disulfide bondi197 ↔ 218By similarity
Disulfide bondi271 ↔ 346By similarity
Disulfide bondi295 ↔ 316By similarity
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1653N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1974N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2074N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2103N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2109PhosphoserineBy similarity1
Glycosylationi2263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2356N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2607PhosphoserineBy similarity1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2612PhosphothreonineBy similarity1
Glycosylationi2623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2641N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2919N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3052N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3078 ↔ 3089By similarity
Disulfide bondi3083 ↔ 3098By similarity
Disulfide bondi3100 ↔ 3109By similarity
Disulfide bondi3116 ↔ 3127By similarity
Disulfide bondi3121 ↔ 3136By similarity
Disulfide bondi3138 ↔ 3147By similarity
Disulfide bondi3154 ↔ 3165By similarity
Disulfide bondi3182 ↔ 3274By similarity
Disulfide bondi3250 ↔ 3266By similarity
Disulfide bondi3281 ↔ 3324By similarity
Disulfide bondi3310 ↔ 3337By similarity
Glycosylationi3354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3364N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1423 – 1424Cleavage; by ADAMTS15By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P81282

PeptideAtlas

More...PeptideAtlasi		P81282

PRoteomics IDEntifications database

More...PRIDEi		P81282

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cerebral white matter. Isoform V0 and isoform V1 are expressed in the central nervous system, and in a number of mesenchymal and epithelial tissues; the major isoform V2 is restricted to the central nervous system.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Disappears after the cartilage development.

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P81282, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000019848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P81282

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 147Ig-like V-typeAdd BLAST127
Domaini151 – 246Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini252 – 348Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini3074 – 3110EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini3112 – 3148EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3161 – 3275C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini3279 – 3339SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 1336GAG-alpha (glucosaminoglycan attachment domain)Add BLAST988
Regioni1337 – 3074GAG-betaAdd BLAST1738

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRBE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156102

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P81282

Database of Orthologous Groups

More...OrthoDBi		74642at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform V0 (identifier: P81282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLINIKSILW MCSTLIAAHA LQKVNMEKSP PVKGSLSGKV NLPCHFSTMP 
        60         70         80         90        100
TLPPSYNTTS EFLRIKWSKI ELDKTGKDLK ETTVLVAQNG NIKIGQDYKG 
       110        120        130        140        150
RVSVPTHPED VGDASLTMVK LLASDAGRYR CDVMYGIEDT QDTVSLTVEG 
       160        170        180        190        200
VVFHYRAATS RYTLNFEMAQ KACVDIGAVI ATPEQLHAAY EDGFEQCDAG 
       210        220        230        240        250
WLSDQTVRYP IRVPREGCYG DMMGKEGVRT YGFRAPHETY DVYCYVDHLD 
       260        270        280        290        300
GDVFHITAPN KFTFEEAGEE CKTQDARLAT VGELQAAWRN GFDRCDYGWL 
       310        320        330        340        350
LDASVRHPVT VARAQCGGGL LGVRTLYRFE NQTGFPTPDS RFDAYCFKPK 
       360        370        380        390        400
QNISEATTIE LNMLAETVSP TLLEELQVGL DRMTPIVPLI TELPVITTKV 
       410        420        430        440        450
PPIGNIVNFE QKSTVQPLTS THRSATESLP PDGSMKKPWD MDYYSPSASG 
       460        470        480        490        500
PLGEPDVSEI KEEVPQSTTV VSHHAPDSWD GVKEDLQIKD SVTQIEQIEV 
       510        520        530        540        550
GPLVTSMEIS KHIPSKEFTV TVTPFVSTTM TLESKTEKKA ISTVSESVTT 
       560        570        580        590        600
SHYGFTLREG DGEDRISTVR SGQSTSIFSQ IPEVITVSKT SEDTTRGQLE 
       610        620        630        640        650
DVESVSASTI VSPDSDGSPM DHRQEKQTHG RITEGFLGQY VSTTPFPSQH 
       660        670        680        690        700
HTEVELFPYS GDKRLVEGTS TVISPTPRTG RERTETLRPA MRTVTYTNDE 
       710        720        730        740        750
IQEKITKDSS IEKIEEEGFS GMKFPTASPE QIHHTKYSVG MTKSFESPAL 
       760        770        780        790        800
MTTTKPGVTP TEATDVEEDF TTPSGLETDG YQDTTEYEEG ITTVHLIQST 
       810        820        830        840        850
LNVEVVTVSK WSLDEDNTTS KPLGSTEHVG SPKLPPALIT TTGVSGKDKE 
       860        870        880        890        900
MPSLTEDGRD EFTRIPGSTQ RPLEEFTEED TTDHEKFTVR FQPTTSIATT 
       910        920        930        940        950
EKSTLRDSIT EERVPPFTST EVRVTHATIE GSALDEGEDV DVSKPLSTVP 
       960        970        980        990       1000
QFAHPSDVEG STFVNYSSTQ EPTTYVDTSH TIPLPVIPKT EWGVLVPSIP 
      1010       1020       1030       1040       1050
SEGEVLGEPS QDIRVINQTH FEASMYPETV RTTTEITQEA TREDFLWKEQ 
      1060       1070       1080       1090       1100
TPEKPVSPPS STTDTAKETT PPLDEQESDG SAYTVFEDRS VMGSDRVSVL 
      1110       1120       1130       1140       1150
VTTPIGKFEQ HTSFPPGAVT KAKTDEVVTL TPTTGSKVTF SPWPKQKYET 
      1160       1170       1180       1190       1200
EGTSPRGFVS PFSIGVTQLI EETTTEKREK TSLDYIDLGS GLFEKPKATE 
      1210       1220       1230       1240       1250
LPEFSTVKAT VPSDTAAFSS ADRLHTPSAS TEKPPLIDRE PDEETTSDMV 
      1260       1270       1280       1290       1300
IIGESTSRVP PTTLEDIVAK KTETDIDREY FTTSSTSTTQ PTRPPTVEGK 
      1310       1320       1330       1340       1350
EAFGPQAFST PEPPAGTKFH PDINVYIIEV RENKTGRMSD FSVSGHPIDS 
      1360       1370       1380       1390       1400
ESKEDEPCSE ETDPEHDLIA EILPELLGML HSEEDEEDEE CANATDVTTT 
      1410       1420       1430       1440       1450
PSVQYINGKH VVTTVPKDPE AAEARRGQFE SVAPSQNFSD SSESDSHQFI 
      1460       1470       1480       1490       1500
ITHAGLPTAM QPNESKETTE SLEITWRPEI YPETAEPFSS GEPDIFPTAS 
      1510       1520       1530       1540       1550
IHEGEATEGP DSITEKNPEL DHLVHEHAES VPLFPEESSG DAAIDQESQK 
      1560       1570       1580       1590       1600
IIFSGATEGT FGEEAEKSST THTPSMVASS VSAPVSEDAS FILTGTPQSD 
      1610       1620       1630       1640       1650
EPLSTVESWV EITPRHTVEF SGSPSIPIPE GSGEAEEDKD KIFAMITDLS 
      1660       1670       1680       1690       1700
QRNTTDPRVT SDTSKIMITE SLVDVPTTTI YSISEQVSAV VPTKFVRETD 
      1710       1720       1730       1740       1750
TYEWVFSPPL EETTRKEEEK GTTGTASTVE VHSPTQRLDQ FVSPSELESS 
      1760       1770       1780       1790       1800
SETPPDDSAA ATRKSFTSQM TPTQSERETT SSTVVFKETE VLDNLAAQTT 
      1810       1820       1830       1840       1850
DPSLSSQPGV LEVSPTVPGS PVSLFMEQGS GEAAVDPETT TVSSLSLNIE 
      1860       1870       1880       1890       1900
PEILAKEEAA GAWSPNVETV FPFEPTEQVL STAVDREVAE TISQTSKENL 
      1910       1920       1930       1940       1950
VSEISGEPTH RAEIKGFSTD FPLEEDFSGD FREYSTVSYP ITKEEIVMME 
      1960       1970       1980       1990       2000
GSGDAAFKDT QMLPSVTPTS DLSNHTADSE EPGSTLVSTS AFPWEEFTAS 
      2010       2020       2030       2040       2050
AEGSGEPLLS VSSSVDQVFP SAAGKASGTD SPFIDQRLGE EGAINETDQR 
      2060       2070       2080       2090       2100
STILPTAEAE STKASTEEGE VKENHTVSMD FPPTVEPDEL WPRQEVNPVR 
      2110       2120       2130       2140       2150
QGNGSEIVSE EKTQEQESFE PLQSSVAPEQ TTFDSQTFPE PGLQTTGYFT 
      2160       2170       2180       2190       2200
LTTKKTYSTD ERMEEEVISL ADVSTPTLDS KGLVLYTTLP EVTEKSHFFL 
      2210       2220       2230       2240       2250
ATASVTESVP AESVIAGSTI KEEESIKPFP KVTSPIIKES DTDLIFSGLG 
      2260       2270       2280       2290       2300
SGEEVLPTLG SVNFTEIEQV LSTLYPLTSQ VQSLEASILN DTSGDYEGME 
      2310       2320       2330       2340       2350
NVANEMRPLI SKTDSIFEDG ETASSTTLPE ILSDARTEGP FTAPLTFSTG 
      2360       2370       2380       2390       2400
PGQPQNQTHR RAEEIQTSRP QPLTDQVSSE NSVTAETKET ATPATDFLAR 
      2410       2420       2430       2440       2450
TYDLEMAKGF VTPTPKPSDL FYEHSGEGSG ELDAVGAEVH ASGMTQATRQ 
      2460       2470       2480       2490       2500
GSTTFVSDRS LEKHPKVPSV EAVTVNGFPT VSMVLPLHPE QREGSPEATG 
      2510       2520       2530       2540       2550
TPASTASYEK ATEGAADSFQ DHFWGFKDST LKPDKRKATE SIIIDLDKED 
      2560       2570       2580       2590       2600
KDLILTMTES TILEIIPELT SDKNTVIDID HTKPIYEDIL GMQTDLDPEV 
      2610       2620       2630       2640       2650
PSGPPDSSEE STQVQEKYEA AVNLSSTEEN FEASGDILLA NYTQATPESK 
      2660       2670       2680       2690       2700
APEDRNPLDH TDFIFTTGIP ILSSETELDV LLPTATSLPI PSKSATVNPE 
      2710       2720       2730       2740       2750
SKTEAKTLED IFESSTLSDG QAIADQSEVI STLGYLERTQ NEDEAKKYVS 
      2760       2770       2780       2790       2800
PSFQPEFSSG AEEALTDPTP YVSIGTTYLT AQSLTEAPDV MEGARLPDSI 
      2810       2820       2830       2840       2850
DTSTVSAFSE LLSQTPSFPP LSIHLGSGDS EHSEDLQPSA LPSTDASTPP 
      2860       2870       2880       2890       2900
VSSGELANIE ATFKPSSEED FYITEPPSLP PDTEPSEDES KPKLLEPTEA 
      2910       2920       2930       2940       2950
SATELIAQEE IEIFQNSDNT TSVQVSGEAV KVFPSIETPE AEAIVTAASE 
      2960       2970       2980       2990       3000
TKLEGATLRP HSTSASVIHG VEAGVVPQPS PQTSERPTIL SPLEISPETQ 
      3010       3020       3030       3040       3050
AALIRGEDST VAAPKQQVPT RMLDSNKQAT LSTTELNTEL ATPSFPLLET 
      3060       3070       3080       3090       3100
SNETSFLIGI NEESVEGTAV YLPGPDRCKM NPCLNGGTCY PTETSYVCTC 
      3110       3120       3130       3140       3150
VPGYSGDRCE LDFDECHSNP CRNGATCIDG FNTFRCLCLP SYVGALCEQD 
      3160       3170       3180       3190       3200
TETCDYGWHK FQGQCYKYFA HRRTWDAAER ECRLQGAHLT SILSHEEQMF 
      3210       3220       3230       3240       3250
VNRVGHDYQW IGLNDKMFEH DFRWTDGSTL QYENWRPNQP DSFFSTGEDC 
      3260       3270       3280       3290       3300
VVIIWHENGQ WNDVPCNYHL TYTCKKGTVA CGQPPVVENA KTFGKMKPRY 
      3310       3320       3330       3340       3350
EINSLIRYHC KDGFIQRHLP TIRCLGNGRW AMPKITCLNP SAYQRTYSKK 
      3360       3370       3380 
YFKNSSSAKD NSINTSKHDH RWSRRWQESR R
Length:3,381
Mass (Da):369,990
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF09716FA7778D459
GO
Isoform V1 (identifier: P81282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: P → R
     350-1336: Missing.

Show »
Length:2,394
Mass (Da):261,888
Checksum:iB82A3E10FC5BD990
GO
Isoform V2 (identifier: P81282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1337-3074: Missing.

Show »
Length:1,643
Mass (Da):182,895
Checksum:iA6F2BFC3A3DEF80A
GO
Isoform V3 (identifier: P81282-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: P → R
     350-3074: Missing.

Show »
Length:656
Mass (Da):74,793
Checksum:iF8FE153BD10C7AB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MZ85F1MZ85_BOVIN
Versican core protein
VCAN
3,371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M9P9A0A3Q1M9P9_BOVIN
Versican core protein
VCAN
3,381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1N6I5F1N6I5_BOVIN
Versican core protein
VCAN
2,394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1MZ83F1MZ83_BOVIN
Versican core protein
VCAN
1,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25Missing AA sequence (PubMed:1720020).Curated1
Sequence conflicti51Missing AA sequence (PubMed:1720020).Curated1
Sequence conflicti89N → D AA sequence (PubMed:1720020).Curated1
Sequence conflicti96Q → D AA sequence (PubMed:1720020).Curated1
Sequence conflicti346C → R AA sequence (PubMed:1720020).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003078349P → R in isoform V1 and isoform V3. 1 Publication1
Alternative sequenceiVSP_003081350 – 3074Missing in isoform V3. 1 PublicationAdd BLAST2725
Alternative sequenceiVSP_003079350 – 1336Missing in isoform V1. 1 PublicationAdd BLAST987
Alternative sequenceiVSP_0030801337 – 3074Missing in isoform V2. 1 PublicationAdd BLAST1738

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF060456 mRNA Translation: AAC24358.1
AF060457 mRNA Translation: AAC24359.1
AF060458 mRNA Translation: AAC24360.1
AF060459 mRNA Translation: AAC24361.1

Protein sequence database of the Protein Information Resource

More...PIRi		T14274
T42389

NCBI Reference Sequences

More...RefSeqi		NP_851378.1, NM_181035.2 [P81282-1]
XP_015327844.1, XM_015472358.1 [P81282-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSBTAT00000042717; ENSBTAP00000040348; ENSBTAG00000014906 [P81282-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:282662

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060456 mRNA Translation: AAC24358.1
AF060457 mRNA Translation: AAC24359.1
AF060458 mRNA Translation: AAC24360.1
AF060459 mRNA Translation: AAC24361.1
PIRiT14274
T42389
RefSeqiNP_851378.1, NM_181035.2 [P81282-1]
XP_015327844.1, XM_015472358.1 [P81282-4]

3D structure databases

SMRiP81282
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019848

Proteomic databases

PaxDbiP81282
PeptideAtlasiP81282
PRIDEiP81282

Genome annotation databases

EnsembliENSBTAT00000042717; ENSBTAP00000040348; ENSBTAG00000014906 [P81282-4]
GeneIDi282662
KEGGibta:282662

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1462
VGNCiVGNC:36778, VCAN

Phylogenomic databases

eggNOGiENOG502QRBE, Eukaryota
GeneTreeiENSGT00940000156102
InParanoidiP81282
OrthoDBi74642at2759

Gene expression databases

ExpressionAtlasiP81282, baseline and differential

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 2 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 2 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 3 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50835, IG_LIKE, 1 hit
PS01241, LINK_1, 2 hits
PS50963, LINK_2, 2 hits
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG2_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81282
Secondary accession number(s): O77609
, O77610, O77611, O77612
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: April 7, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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