UniProtKB - P81270 (ERG_MOUSE)
Protein
Transcriptional regulator ERG
Gene
Erg
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 318 – 398 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulator ERG |
Gene namesi | Name:Erg Synonyms:Erg-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95415, Erg |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204104 | 1 – 486 | Transcriptional regulator ERGAdd BLAST | 486 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | PhosphoserineCombined sources | 1 | |
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Cross-linki | 289 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P81270 |
PaxDbi | P81270 |
PRIDEi | P81270 |
PTM databases
iPTMneti | P81270 |
PhosphoSitePlusi | P81270 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040732, Expressed in brain blood vessel and 280 other tissues |
ExpressionAtlasi | P81270, baseline and differential |
Genevisiblei | P81270, MM |
Interactioni
Subunit structurei
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with SETDB1.
1 PublicationBinary interactionsi
P81270
With | #Exp. | IntAct |
---|---|---|
Setdb1 [O88974] | 3 | EBI-79647,EBI-79658 |
Protein-protein interaction databases
BioGRIDi | 199504, 5 interactors |
IntActi | P81270, 2 interactors |
MINTi | P81270 |
STRINGi | 10090.ENSMUSP00000109477 |
Miscellaneous databases
RNActi | P81270, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 206 | PNTPROSITE-ProRule annotationAdd BLAST | 87 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160662 |
InParanoidi | P81270 |
OrthoDBi | 1113327at2759 |
PhylomeDBi | P81270 |
TreeFami | TF350537 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: P81270-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM
110 120 130 140 150
VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS
460 470 480
SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PY05 | E9PY05_MOUSE | Transcriptional regulator ERG | Erg | 439 | Annotation score: | ||
H3BKX4 | H3BKX4_MOUSE | Transcriptional regulator ERG | Erg | 387 | Annotation score: | ||
I1E4Y2 | I1E4Y2_MOUSE | Transcriptional regulator ERG | Erg | 455 | Annotation score: | ||
A0A384DVA0 | A0A384DVA0_MOUSE | Transcriptional regulator ERG | Erg | 456 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 175 | L → Q in BAC37131 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026585 | 1 – 11 | MIQTVPDPAAH → MAST in isoform 5. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_007641 | 232 – 255 | Missing in isoform 1. 2 PublicationsAdd BLAST | 24 | |
Alternative sequenceiVSP_007642 | 256 – 278 | Missing in isoform 2. 2 PublicationsAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073078 mRNA Translation: BAB69948.1 AB073079 mRNA Translation: BAB69949.1 AB073080 mRNA Translation: BAB69950.1 AK050922 mRNA Translation: BAC34461.1 AK078113 mRNA Translation: BAC37131.1 BC145850 mRNA Translation: AAI45851.1 S66169 mRNA Translation: AAB28525.1 |
CCDSi | CCDS37411.1 [P81270-1] CCDS79493.1 [P81270-4] CCDS79495.1 [P81270-3] CCDS79496.1 [P81270-2] |
PIRi | A54617 |
RefSeqi | NP_001289081.1, NM_001302152.1 [P81270-3] NP_001289082.1, NM_001302153.1 [P81270-4] NP_001289083.1, NM_001302154.1 NP_001289108.1, NM_001302179.1 [P81270-2] NP_001289112.1, NM_001302183.1 NP_598420.1, NM_133659.3 [P81270-1] XP_006522957.1, XM_006522894.3 [P81270-1] XP_006522958.1, XM_006522895.2 [P81270-1] XP_006522959.1, XM_006522896.3 [P81270-1] XP_006522962.1, XM_006522899.3 [P81270-2] XP_006522963.1, XM_006522900.2 [P81270-3] |
Genome annotation databases
Ensembli | ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732 [P81270-2] ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732 [P81270-4] ENSMUST00000233269; ENSMUSP00000156926; ENSMUSG00000040732 [P81270-3] ENSMUST00000233881; ENSMUSP00000156669; ENSMUSG00000040732 [P81270-1] |
GeneIDi | 13876 |
KEGGi | mmu:13876 |
UCSCi | uc008acb.2, mouse [P81270-1] uc008acc.2, mouse [P81270-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073078 mRNA Translation: BAB69948.1 AB073079 mRNA Translation: BAB69949.1 AB073080 mRNA Translation: BAB69950.1 AK050922 mRNA Translation: BAC34461.1 AK078113 mRNA Translation: BAC37131.1 BC145850 mRNA Translation: AAI45851.1 S66169 mRNA Translation: AAB28525.1 |
CCDSi | CCDS37411.1 [P81270-1] CCDS79493.1 [P81270-4] CCDS79495.1 [P81270-3] CCDS79496.1 [P81270-2] |
PIRi | A54617 |
RefSeqi | NP_001289081.1, NM_001302152.1 [P81270-3] NP_001289082.1, NM_001302153.1 [P81270-4] NP_001289083.1, NM_001302154.1 NP_001289108.1, NM_001302179.1 [P81270-2] NP_001289112.1, NM_001302183.1 NP_598420.1, NM_133659.3 [P81270-1] XP_006522957.1, XM_006522894.3 [P81270-1] XP_006522958.1, XM_006522895.2 [P81270-1] XP_006522959.1, XM_006522896.3 [P81270-1] XP_006522962.1, XM_006522899.3 [P81270-2] XP_006522963.1, XM_006522900.2 [P81270-3] |
3D structure databases
BMRBi | P81270 |
SMRi | P81270 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199504, 5 interactors |
IntActi | P81270, 2 interactors |
MINTi | P81270 |
STRINGi | 10090.ENSMUSP00000109477 |
PTM databases
iPTMneti | P81270 |
PhosphoSitePlusi | P81270 |
Proteomic databases
MaxQBi | P81270 |
PaxDbi | P81270 |
PRIDEi | P81270 |
Protocols and materials databases
Antibodypediai | 4338, 568 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732 [P81270-2] ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732 [P81270-4] ENSMUST00000233269; ENSMUSP00000156926; ENSMUSG00000040732 [P81270-3] ENSMUST00000233881; ENSMUSP00000156669; ENSMUSG00000040732 [P81270-1] |
GeneIDi | 13876 |
KEGGi | mmu:13876 |
UCSCi | uc008acb.2, mouse [P81270-1] uc008acc.2, mouse [P81270-2] |
Organism-specific databases
CTDi | 2078 |
MGIi | MGI:95415, Erg |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000160662 |
InParanoidi | P81270 |
OrthoDBi | 1113327at2759 |
PhylomeDBi | P81270 |
TreeFami | TF350537 |
Miscellaneous databases
BioGRID-ORCSi | 13876, 0 hits in 17 CRISPR screens |
ChiTaRSi | Erg, mouse |
PROi | PR:P81270 |
RNActi | P81270, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040732, Expressed in brain blood vessel and 280 other tissues |
ExpressionAtlasi | P81270, baseline and differential |
Genevisiblei | P81270, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERG_MOUSE | |
Accessioni | P81270Primary (citable) accession number: P81270 Secondary accession number(s): A6H6E7 Q920K9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 20, 2003 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families