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Protein

Transcriptional regulator ERG

Gene

Erg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi318 – 398ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Gene namesi
Name:Erg
Synonyms:Erg-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:95415 Erg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041041 – 486Transcriptional regulator ERGAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP81270
PaxDbiP81270
PRIDEiP81270

PTM databases

iPTMnetiP81270
PhosphoSitePlusiP81270

Expressioni

Gene expression databases

BgeeiENSMUSG00000040732 Expressed in 257 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiP81270 baseline and differential
GenevisibleiP81270 MM

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Setdb1O889743EBI-79647,EBI-79658

Protein-protein interaction databases

BioGridi199504, 5 interactors
IntActiP81270, 2 interactors
MINTiP81270
STRINGi10090.ENSMUSP00000109477

Structurei

3D structure databases

ProteinModelPortaliP81270
SMRiP81270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 206PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000290658
HOVERGENiHBG001553
InParanoidiP81270
KOiK09435
OrthoDBiEOG091G0EWP
PhylomeDBiP81270
TreeFamiTF350537

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P81270-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM
110 120 130 140 150
VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS
460 470 480
SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY
Length:486
Mass (Da):54,614
Last modified:June 20, 2003 - v2
Checksum:iBF1ADF00A4772F75
GO
Isoform 1 (identifier: P81270-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,037
Checksum:i0EA419B53ECA5591
GO
Isoform 2 (identifier: P81270-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.

Show »
Length:463
Mass (Da):51,971
Checksum:i510D2BB76663D4A4
GO
Isoform 5 (identifier: P81270-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,843
Checksum:iBAA90BE63412B968
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PY05E9PY05_MOUSE
Transcriptional regulator ERG
Erg
439Annotation score:
H3BKX4H3BKX4_MOUSE
Transcriptional regulator ERG
Erg
387Annotation score:
I1E4Y2I1E4Y2_MOUSE
Transcriptional regulator ERG
Erg
455Annotation score:
A0A384DVA0A0A384DVA0_MOUSE
Transcriptional regulator ERG
Erg
456Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → Q in BAC37131 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265851 – 11MIQTVPDPAAH → MAST in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_007641232 – 255Missing in isoform 1. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_007642256 – 278Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073078 mRNA Translation: BAB69948.1
AB073079 mRNA Translation: BAB69949.1
AB073080 mRNA Translation: BAB69950.1
AK050922 mRNA Translation: BAC34461.1
AK078113 mRNA Translation: BAC37131.1
BC145850 mRNA Translation: AAI45851.1
S66169 mRNA Translation: AAB28525.1
CCDSiCCDS37411.1 [P81270-1]
CCDS79493.1 [P81270-4]
CCDS79495.1 [P81270-3]
CCDS79496.1 [P81270-2]
PIRiA54617
RefSeqiNP_001289081.1, NM_001302152.1 [P81270-3]
NP_001289082.1, NM_001302153.1 [P81270-4]
NP_001289083.1, NM_001302154.1
NP_001289108.1, NM_001302179.1 [P81270-2]
NP_001289112.1, NM_001302183.1
NP_598420.1, NM_133659.3 [P81270-1]
XP_006522957.1, XM_006522894.3 [P81270-1]
XP_006522958.1, XM_006522895.2 [P81270-1]
XP_006522959.1, XM_006522896.3 [P81270-1]
XP_006522962.1, XM_006522899.3 [P81270-2]
XP_006522963.1, XM_006522900.2 [P81270-3]
UniGeneiMm.164531

Genome annotation databases

EnsembliENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732 [P81270-1]
ENSMUST00000121809; ENSMUSP00000113723; ENSMUSG00000040732 [P81270-3]
ENSMUST00000176345; ENSMUSP00000135568; ENSMUSG00000040732 [P81270-4]
GeneIDi13876
KEGGimmu:13876
UCSCiuc008acb.2 mouse [P81270-1]
uc008acc.2 mouse [P81270-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073078 mRNA Translation: BAB69948.1
AB073079 mRNA Translation: BAB69949.1
AB073080 mRNA Translation: BAB69950.1
AK050922 mRNA Translation: BAC34461.1
AK078113 mRNA Translation: BAC37131.1
BC145850 mRNA Translation: AAI45851.1
S66169 mRNA Translation: AAB28525.1
CCDSiCCDS37411.1 [P81270-1]
CCDS79493.1 [P81270-4]
CCDS79495.1 [P81270-3]
CCDS79496.1 [P81270-2]
PIRiA54617
RefSeqiNP_001289081.1, NM_001302152.1 [P81270-3]
NP_001289082.1, NM_001302153.1 [P81270-4]
NP_001289083.1, NM_001302154.1
NP_001289108.1, NM_001302179.1 [P81270-2]
NP_001289112.1, NM_001302183.1
NP_598420.1, NM_133659.3 [P81270-1]
XP_006522957.1, XM_006522894.3 [P81270-1]
XP_006522958.1, XM_006522895.2 [P81270-1]
XP_006522959.1, XM_006522896.3 [P81270-1]
XP_006522962.1, XM_006522899.3 [P81270-2]
XP_006522963.1, XM_006522900.2 [P81270-3]
UniGeneiMm.164531

3D structure databases

ProteinModelPortaliP81270
SMRiP81270
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199504, 5 interactors
IntActiP81270, 2 interactors
MINTiP81270
STRINGi10090.ENSMUSP00000109477

PTM databases

iPTMnetiP81270
PhosphoSitePlusiP81270

Proteomic databases

MaxQBiP81270
PaxDbiP81270
PRIDEiP81270

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732 [P81270-1]
ENSMUST00000121809; ENSMUSP00000113723; ENSMUSG00000040732 [P81270-3]
ENSMUST00000176345; ENSMUSP00000135568; ENSMUSG00000040732 [P81270-4]
GeneIDi13876
KEGGimmu:13876
UCSCiuc008acb.2 mouse [P81270-1]
uc008acc.2 mouse [P81270-2]

Organism-specific databases

CTDi2078
MGIiMGI:95415 Erg

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000290658
HOVERGENiHBG001553
InParanoidiP81270
KOiK09435
OrthoDBiEOG091G0EWP
PhylomeDBiP81270
TreeFamiTF350537

Miscellaneous databases

PROiPR:P81270
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040732 Expressed in 257 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiP81270 baseline and differential
GenevisibleiP81270 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERG_MOUSE
AccessioniPrimary (citable) accession number: P81270
Secondary accession number(s): A6H6E7
, Q8C5L4, Q920K7, Q920K8, Q920K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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