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Protein

Zinc finger protein Helios

Gene

Ikzf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with Ikaros at centromeric heterochromatin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Helios
Alternative name(s):
Ikaros family zinc finger protein 2
Gene namesi
Name:Ikzf2
Synonyms:Helios, Zfpn1a2, Znfn1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1342541 Ikzf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470931 – 526Zinc finger protein HeliosAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei288N6-acetyllysineBy similarity1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP81183
PaxDbiP81183
PRIDEiP81183

PTM databases

iPTMnetiP81183
PhosphoSitePlusiP81183

Expressioni

Tissue specificityi

Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle.

Gene expression databases

BgeeiENSMUSG00000025997 Expressed in 205 organ(s), highest expression level in conjunctival fornix
CleanExiMM_IKZF2
ExpressionAtlasiP81183 baseline and differential
GenevisibleiP81183 MM

Interactioni

Subunit structurei

Interacts with IKZF4 AND IKZF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204701, 1 interactor
CORUMiP81183
STRINGi10090.ENSMUSP00000027146

Structurei

3D structure databases

ProteinModelPortaliP81183
SMRiP81183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074392
HOGENOMiHOG000049114
HOVERGENiHBG004752
InParanoidiP81183
KOiK09220
TreeFamiTF331189

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P81183-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METDAIDGYI TCDNELSPEG EHANMAIDLT SSTPNGQHAS PSHMTSTNSV
60 70 80 90 100
KLEMQSDEEC DRQPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQDLQ
110 120 130 140 150
GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT
160 170 180 190 200
QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY
210 220 230 240 250
CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI
260 270 280 290 300
MDNNISLVPF ERPAVIEKLT ANMGKRKSST PQKFVGEKLM RFSYPDIHFD
310 320 330 340 350
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHA PSTIAEVAPV
360 370 380 390 400
ISSAYSQVYH PNRIERPISR ETSDSHENNM DGPISLIRPK SRPQEREASP
410 420 430 440 450
SNSCLDSTDS ESSHDDRQSY QGNPALNPKR KQSPAYMKED VKALDATKAP
460 470 480 490 500
KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE
510 520
CNICGYRSQD RYEFSSHIVR GEHTFH
Length:526
Mass (Da):59,401
Last modified:July 27, 2011 - v2
Checksum:iD70217FE9CCC2F7D
GO
Isoform A (identifier: P81183-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.

Show »
Length:500
Mass (Da):56,592
Checksum:i953343DD5F14593F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNY4A0A087WNY4_MOUSE
Zinc finger protein Helios
Ikzf2
532Annotation score:
A0A087WQ51A0A087WQ51_MOUSE
Zinc finger protein Helios
Ikzf2
452Annotation score:
A0A087WQ74A0A087WQ74_MOUSE
Zinc finger protein Helios
Ikzf2
454Annotation score:
A0A087WNX1A0A087WNX1_MOUSE
Zinc finger protein Helios
Ikzf2
381Annotation score:
A0A087WQX2A0A087WQX2_MOUSE
Zinc finger protein Helios
Ikzf2
99Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti384I → T in AAC00513 (PubMed:9512513).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006846111 – 136Missing in isoform A. CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044257 mRNA Translation: AAC00513.1
AK047925 mRNA Translation: BAC33191.1
CH466548 Genomic DNA Translation: EDL00252.1
BC138606 mRNA Translation: AAI38607.1
BC138608 mRNA Translation: AAI38609.1
CCDSiCCDS15026.1 [P81183-1]
RefSeqiNP_035900.2, NM_011770.4 [P81183-1]
XP_006496029.1, XM_006495966.3 [P81183-1]
XP_006496030.1, XM_006495967.3 [P81183-1]
XP_017175888.1, XM_017320399.1 [P81183-1]
UniGeneiMm.106343

Genome annotation databases

EnsembliENSMUST00000027146; ENSMUSP00000027146; ENSMUSG00000025997 [P81183-1]
ENSMUST00000187184; ENSMUSP00000141075; ENSMUSG00000025997 [P81183-2]
GeneIDi22779
KEGGimmu:22779
UCSCiuc007bjd.2 mouse [P81183-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044257 mRNA Translation: AAC00513.1
AK047925 mRNA Translation: BAC33191.1
CH466548 Genomic DNA Translation: EDL00252.1
BC138606 mRNA Translation: AAI38607.1
BC138608 mRNA Translation: AAI38609.1
CCDSiCCDS15026.1 [P81183-1]
RefSeqiNP_035900.2, NM_011770.4 [P81183-1]
XP_006496029.1, XM_006495966.3 [P81183-1]
XP_006496030.1, XM_006495967.3 [P81183-1]
XP_017175888.1, XM_017320399.1 [P81183-1]
UniGeneiMm.106343

3D structure databases

ProteinModelPortaliP81183
SMRiP81183
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204701, 1 interactor
CORUMiP81183
STRINGi10090.ENSMUSP00000027146

PTM databases

iPTMnetiP81183
PhosphoSitePlusiP81183

Proteomic databases

MaxQBiP81183
PaxDbiP81183
PRIDEiP81183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027146; ENSMUSP00000027146; ENSMUSG00000025997 [P81183-1]
ENSMUST00000187184; ENSMUSP00000141075; ENSMUSG00000025997 [P81183-2]
GeneIDi22779
KEGGimmu:22779
UCSCiuc007bjd.2 mouse [P81183-1]

Organism-specific databases

CTDi22807
MGIiMGI:1342541 Ikzf2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074392
HOGENOMiHOG000049114
HOVERGENiHBG004752
InParanoidiP81183
KOiK09220
TreeFamiTF331189

Miscellaneous databases

PROiPR:P81183
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025997 Expressed in 205 organ(s), highest expression level in conjunctival fornix
CleanExiMM_IKZF2
ExpressionAtlasiP81183 baseline and differential
GenevisibleiP81183 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIKZF2_MOUSE
AccessioniPrimary (citable) accession number: P81183
Secondary accession number(s): Q8C8A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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