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UniProtKB - P81172 (HEPC_HUMAN)

Protein

Hepcidin

Gene

HAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).1 Publication
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • iron channel inhibitor activity Source: BHF-UCL
  • signaling receptor binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide, Hormone

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P81172

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.37.1.2 the hepcidin (hepcidin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepcidin
Alternative name(s):
Liver-expressed antimicrobial peptide 1
Short name:
LEAP-1
Putative liver tumor regressor
Short name:
PLTR
Cleaved into the following 2 chains:
Hepcidin-25
Short name:
Hepc25
Hepcidin-20
Short name:
Hepc20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAMP
Synonyms:HEPC, LEAP1
ORF Names:UNQ487/PRO1003
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000105697.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:15598 HAMP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606464 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P81172

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hemochromatosis 2B (HFE2B)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.
See also OMIM:613313
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04251259R → G in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs779021719EnsemblClinVar.1
Natural variantiVAR_04251370C → R in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs1374259518Ensembl.1
Natural variantiVAR_02664871G → D in HFE2B. 3 PublicationsCorresponds to variant dbSNP:rs104894696EnsemblClinVar.1
Natural variantiVAR_04251478C → Y in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs1462013476Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		57817

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		HAMP

MalaCards human disease database

More...MalaCardsi		HAMP
MIMi613313 phenotype

Open Targets

More...OpenTargetsi		ENSG00000105697

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79230 Hemochromatosis type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29182

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3989381

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HAMP

Domain mapping of disease mutations (DMDM)

More...DMDMi		10720397

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001337825 – 54Add BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001337960 – 84Hepcidin-25Add BLAST25
PeptideiPRO_000001338065 – 84Hepcidin-20Add BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 821 Publication
Disulfide bondi69 ↔ 721 Publication
Disulfide bondi70 ↔ 781 Publication
Disulfide bondi73 ↔ 811 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P81172

PeptideAtlas

More...PeptideAtlasi		P81172

PRoteomics IDEntifications database

More...PRIDEi		P81172

ProteomicsDB human proteome resource

More...ProteomicsDBi		57692

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105697 Expressed in 200 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...CleanExi		HS_HAMP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P81172 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121776, 2 interactors

Protein interaction database and analysis system

More...IntActi		P81172, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222304

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4ENMR-A65-84[»]
1M4FNMR-A60-84[»]
2KEFNMR-A60-84[»]
3H0TX-ray1.89C60-84[»]
4QAEX-ray2.10P/Q/R/S/T/U60-84[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P81172

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P81172

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P81172

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J3JD Eukaryota
ENOG4111C2J LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000008666

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG003716

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P81172

Identification of Orthologs from Complete Genome Data

More...OMAi		GARAGWT

Database of Orthologous Groups

More...OrthoDBi		1623838at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P81172

TreeFam database of animal gene trees

More...TreeFami		TF330932

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010500 Hepcidin

The PANTHER Classification System

More...PANTHERi		PTHR16877 PTHR16877, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06446 Hepcidin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P81172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM 
        60         70         80 
PMFQRRRRRD THFPICIFCC GCCHRSKCGM CCKT
Length:84
Mass (Da):9,408
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F8DCA23D19D29F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31T → M in AAK14912 (Ref. 3) Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 2789.8 Da from positions 60 - 84. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04251259R → G in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs779021719EnsemblClinVar.1
Natural variantiVAR_04251370C → R in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs1374259518Ensembl.1
Natural variantiVAR_02664871G → D in HFE2B. 3 PublicationsCorresponds to variant dbSNP:rs104894696EnsemblClinVar.1
Natural variantiVAR_04251478C → Y in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs1462013476Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF309489 mRNA Translation: AAG23966.1
AJ277280 mRNA Translation: CAC09419.1
AF131292 mRNA Translation: AAK14912.1
AY358669 mRNA Translation: AAQ89032.1
DQ496109 Genomic DNA Translation: ABF47098.1
AD000684 Genomic DNA No translation available.
BC020612 mRNA Translation: AAH20612.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12454.1

NCBI Reference Sequences

More...RefSeqi		NP_066998.1, NM_021175.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.8821

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222304; ENSP00000222304; ENSG00000105697
ENST00000598398; ENSP00000471894; ENSG00000105697

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57817

UCSC genome browser

More...UCSCi		uc002nyw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Hepcidin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309489 mRNA Translation: AAG23966.1
AJ277280 mRNA Translation: CAC09419.1
AF131292 mRNA Translation: AAK14912.1
AY358669 mRNA Translation: AAQ89032.1
DQ496109 Genomic DNA Translation: ABF47098.1
AD000684 Genomic DNA No translation available.
BC020612 mRNA Translation: AAH20612.1
CCDSiCCDS12454.1
RefSeqiNP_066998.1, NM_021175.3
UniGeneiHs.8821

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4ENMR-A65-84[»]
1M4FNMR-A60-84[»]
2KEFNMR-A60-84[»]
3H0TX-ray1.89C60-84[»]
4QAEX-ray2.10P/Q/R/S/T/U60-84[»]
ProteinModelPortaliP81172
SMRiP81172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121776, 2 interactors
IntActiP81172, 2 interactors
STRINGi9606.ENSP00000222304

Chemistry databases

ChEMBLiCHEMBL3989381

Protein family/group databases

TCDBi8.A.37.1.2 the hepcidin (hepcidin) family

Polymorphism and mutation databases

BioMutaiHAMP
DMDMi10720397

Proteomic databases

PaxDbiP81172
PeptideAtlasiP81172
PRIDEiP81172
ProteomicsDBi57692

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222304; ENSP00000222304; ENSG00000105697
ENST00000598398; ENSP00000471894; ENSG00000105697
GeneIDi57817
KEGGihsa:57817
UCSCiuc002nyw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57817
DisGeNETi57817
EuPathDBiHostDB:ENSG00000105697.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		HAMP
GeneReviewsiHAMP
HGNCiHGNC:15598 HAMP
MalaCardsiHAMP
MIMi606464 gene
613313 phenotype
neXtProtiNX_P81172
OpenTargetsiENSG00000105697
Orphaneti79230 Hemochromatosis type 2
PharmGKBiPA29182

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J3JD Eukaryota
ENOG4111C2J LUCA
GeneTreeiENSGT00390000003154
HOGENOMiHOG000008666
HOVERGENiHBG003716
InParanoidiP81172
OMAiGARAGWT
OrthoDBi1623838at2759
PhylomeDBiP81172
TreeFamiTF330932

Enzyme and pathway databases

SIGNORiP81172

Miscellaneous databases

EvolutionaryTraceiP81172

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HAMP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57817

Protein Ontology

More...PROi		PR:P81172

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105697 Expressed in 200 organ(s), highest expression level in liver
CleanExiHS_HAMP
GenevisibleiP81172 HS

Family and domain databases

InterProiView protein in InterPro
IPR010500 Hepcidin
PANTHERiPTHR16877 PTHR16877, 1 hit
PfamiView protein in Pfam
PF06446 Hepcidin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEPC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81172
Secondary accession number(s): Q1HE14, Q9BY68
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 1, 2000
Last modified: January 16, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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