HAMP

Functionⁱ

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).1 Publication

Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).2 Publications

GO - Molecular functionⁱ

hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
- 22682227
iron channel inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15514116
- 22682227

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute-phase response Source: Ensembl
aging Source: Ensembl
antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 11034317
- 11113131
cellular iron ion homeostasis
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
cellular response to bile acid Source: Ensembl
cellular response to interleukin-6 Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
cellular response to X-ray Source: Ensembl
defense response to bacterium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to fungus
Source: UniProtKB
Inferred from direct assayⁱ
- 11113131
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 11034317
- 11113131
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 11034317
- 11113131
immune response
Source: UniProtKB
Traceable author statementⁱ
- 11113131
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 11113131
liver regeneration Source: Ensembl
multicellular organismal iron ion homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12469120
negative regulation of ferrous iron export
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
negative regulation of intestinal absorption
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12469120
negative regulation of ion transmembrane transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
negative regulation of iron channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
negative regulation of iron ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
positive regulation of protein polyubiquitination
Source: BHF-UCL
Inferred from direct assayⁱ
- 22682227
positive regulation of receptor catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
positive regulation of receptor internalization
Source: BHF-UCL
Inferred from direct assayⁱ
- 15514116
response to erythropoietin Source: Ensembl
response to ethanol Source: Ensembl
response to iron ion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12469120
response to iron ion starvation Source: Ensembl
response to vitamin A Source: Ensembl
response to zinc ion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Fungicide, Hormone

Molecular function

Antibiotic, Antimicrobial, Fungicide, Hormone

Enzyme and pathway databases

SIGNORⁱ	P81172

SIGNORⁱ

P81172

Protein family/group databases

TCDBⁱ	8.A.37.1.2 the hepcidin (hepcidin) family

TCDBⁱ

8.A.37.1.2 the hepcidin (hepcidin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepcidin Alternative name(s): Liver-expressed antimicrobial peptide 1 Short name: LEAP-1 Putative liver tumor regressor Short name: PLTR Cleaved into the following 2 chains: Hepcidin-25 Short name: Hepc25 Hepcidin-20 Short name: Hepc20
Gene namesⁱ	Name:HAMP Synonyms:HEPC, LEAP1 ORF Names:UNQ487/PRO1003
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105697.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15598 HAMP
MIMⁱ	606464 gene
neXtProtⁱ	NX_P81172

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hemochromatosis 2B (HFE2B)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57817
GeneReviewsⁱ	HAMP
MalaCards human disease database More...MalaCardsⁱ	HAMP
MIMⁱ	613313 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000105697
Orphanetⁱ	79230 Hemochromatosis type 2
PharmGKBⁱ	PA29182

Chemistry databases

ChEMBLⁱ	CHEMBL3989381

ChEMBLⁱ

CHEMBL3989381

Polymorphism and mutation databases

BioMutaⁱ	HAMP
DMDMⁱ	10720397

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST	24
PropeptideⁱPRO_0000013378	25 – 54	Add BLAST	30
PeptideⁱPRO_0000013379	60 – 84	Hepcidin-25Add BLAST	25
PeptideⁱPRO_0000013380	65 – 84	Hepcidin-20Add BLAST	20

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	66 ↔ 82	1 Publication
Disulfide bondⁱ	69 ↔ 72	1 Publication
Disulfide bondⁱ	70 ↔ 78	1 Publication
Disulfide bondⁱ	73 ↔ 81	1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	P81172
PeptideAtlas More...PeptideAtlasⁱ	P81172
PRIDEⁱ	P81172
ProteomicsDBⁱ	57692

Expressionⁱ

Tissue specificityⁱ

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105697 Expressed in 200 organ(s), highest expression level in liver
CleanExⁱ	HS_HAMP
Genevisibleⁱ	P81172 HS

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121776, 2 interactors
IntActⁱ	P81172, 2 interactors
STRINGⁱ	9606.ENSP00000222304

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	66 – 71	Combined sources		6
Beta strandⁱ	76 – 82	Combined sources		7

Show more details

3D structure databases

ProteinModelPortalⁱ	P81172
SMRⁱ	P81172
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P81172

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the hepcidin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3JD Eukaryota ENOG4111C2J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003154
HOGENOMⁱ	HOG000008666
HOVERGENⁱ	HBG003716
InParanoidⁱ	P81172
OMAⁱ	GARAGWT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1A4A
PhylomeDBⁱ	P81172
TreeFamⁱ	TF330932

Family and domain databases

InterProⁱ	View protein in InterPro IPR010500 Hepcidin
PANTHERⁱ	PTHR16877 PTHR16877, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06446 Hepcidin, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P81172-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM 
        60         70         80 
PMFQRRRRRD THFPICIFCC GCCHRSKCGM CCKT

Length:84

Mass (Da):9,408

Last modified:December 1, 2000 - v2

Checksum:ⁱ5F8DCA23D19D29F7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	31	T → M in AAK14912 (Ref. 3) Curated		1

Mass spectrometryⁱ

Molecular mass is 2789.8 Da from positions 60 - 84. Determined by MALDI. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042512	59	R → G in HFE2B. 1 PublicationCorresponds to variant dbSNP:rs779021719EnsemblClinVar.	1
Natural variantⁱVAR_042513	70	C → R in HFE2B. 1 Publication	1
Natural variantⁱVAR_026648	71	G → D in HFE2B. 3 PublicationsCorresponds to variant dbSNP:rs104894696EnsemblClinVar.	1
Natural variantⁱVAR_042514	78	C → Y in HFE2B. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF309489 mRNA Translation: AAG23966.1 AJ277280 mRNA Translation: CAC09419.1 AF131292 mRNA Translation: AAK14912.1 AY358669 mRNA Translation: AAQ89032.1 DQ496109 Genomic DNA Translation: ABF47098.1 AD000684 Genomic DNA No translation available. BC020612 mRNA Translation: AAH20612.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12454.1
NCBI Reference Sequences More...RefSeqⁱ	NP_066998.1, NM_021175.3
UniGeneⁱ	Hs.8821

Genome annotation databases

Ensemblⁱ	ENST00000222304; ENSP00000222304; ENSG00000105697 ENST00000598398; ENSP00000471894; ENSG00000105697
GeneIDⁱ	57817
KEGGⁱ	hsa:57817
UCSC genome browser More...UCSCⁱ	uc002nyw.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P81172	Hepcidin antimicrobial peptide (Fragment)		HUMAN		54	UniRef100_P81172

Protein	Similar proteins		Species	Score	Length	Source
P81172	Hepcidin antimicrobial peptide (Fragment)		HUMAN		54	UniRef90_P81172
Hepcidin antimicrobial peptide		MACMU		84
Hepcidin		MACFA		84
Hepcidin		PAPPA		84
Uncharacterized protein		CHLSB		84
+13

Protein	Similar proteins		Species	Score	Length	Source
P81172	Hepcidin		RAT		84	UniRef50_P81172
Hepcidin		PONAB		84
Hepcidin antimicrobial peptide (Fragment)		HUMAN		54
Hepcidin		PREME		84
Hepcidin		TRACR		84
+56

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Hepcidin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF309489 mRNA Translation: AAG23966.1 AJ277280 mRNA Translation: CAC09419.1 AF131292 mRNA Translation: AAK14912.1 AY358669 mRNA Translation: AAQ89032.1 DQ496109 Genomic DNA Translation: ABF47098.1 AD000684 Genomic DNA No translation available. BC020612 mRNA Translation: AAH20612.1
CCDSⁱ	CCDS12454.1
RefSeqⁱ	NP_066998.1, NM_021175.3
UniGeneⁱ	Hs.8821

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M4E	NMR	-	A	65-84	[»]
	1M4F	NMR	-	A	60-84	[»]
	2KEF	NMR	-	A	60-84	[»]
	3H0T	X-ray	1.89	C	60-84	[»]
	4QAE	X-ray	2.10	P/Q/R/S/T/U	60-84	[»]
ProteinModelPortalⁱ	P81172
SMRⁱ	P81172
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121776, 2 interactors
IntActⁱ	P81172, 2 interactors
STRINGⁱ	9606.ENSP00000222304

Chemistry databases

ChEMBLⁱ	CHEMBL3989381

ChEMBLⁱ

CHEMBL3989381

Protein family/group databases

TCDBⁱ	8.A.37.1.2 the hepcidin (hepcidin) family

TCDBⁱ

8.A.37.1.2 the hepcidin (hepcidin) family

Polymorphism and mutation databases

BioMutaⁱ	HAMP
DMDMⁱ	10720397

Proteomic databases

PaxDbⁱ	P81172
PeptideAtlasⁱ	P81172
PRIDEⁱ	P81172
ProteomicsDBⁱ	57692

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000222304; ENSP00000222304; ENSG00000105697 ENST00000598398; ENSP00000471894; ENSG00000105697
GeneIDⁱ	57817
KEGGⁱ	hsa:57817
UCSCⁱ	uc002nyw.4 human

Organism-specific databases

CTDⁱ	57817
DisGeNETⁱ	57817
EuPathDBⁱ	HostDB:ENSG00000105697.7
GeneCardsⁱ	HAMP
GeneReviewsⁱ	HAMP
HGNCⁱ	HGNC:15598 HAMP
MalaCardsⁱ	HAMP
MIMⁱ	606464 gene 613313 phenotype
neXtProtⁱ	NX_P81172
OpenTargetsⁱ	ENSG00000105697
Orphanetⁱ	79230 Hemochromatosis type 2
PharmGKBⁱ	PA29182
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J3JD Eukaryota ENOG4111C2J LUCA
GeneTreeⁱ	ENSGT00390000003154
HOGENOMⁱ	HOG000008666
HOVERGENⁱ	HBG003716
InParanoidⁱ	P81172
OMAⁱ	GARAGWT
OrthoDBⁱ	EOG091G1A4A
PhylomeDBⁱ	P81172
TreeFamⁱ	TF330932

Enzyme and pathway databases

SIGNORⁱ	P81172

SIGNORⁱ

P81172

Miscellaneous databases

EvolutionaryTraceⁱ	P81172
GeneWikiⁱ	HAMP
GenomeRNAiⁱ	57817
Protein Ontology More...PROⁱ	PR:P81172
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105697 Expressed in 200 organ(s), highest expression level in liver
CleanExⁱ	HS_HAMP
Genevisibleⁱ	P81172 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010500 Hepcidin
PANTHERⁱ	PTHR16877 PTHR16877, 1 hit
Pfamⁱ	View protein in Pfam PF06446 Hepcidin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HEPC_HUMAN
Accessionⁱ	P81172Primary (citable) accession number: P81172 Secondary accession number(s): Q1HE14, Q9BY68
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P81172 (HEPC_HUMAN)

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Hepcidin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ