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UniProtKB - P81165 (PA2H2_CERGO)
Protein
Basic phospholipase A2 homolog GodMT-II
Gene
N/A
Organism
Cerrophidion godmani (Porthidium godmani) (Bothrops godmani)
Status
Functioni
Snake venom phospholipase A2 homolog that lacks enzymatic activity but shows high myotoxic activities (PubMed:1524423).
In vivo, induces a mild edema when subcutaneously injected into mice foot pad (PubMed:1524423).
1 PublicationMiscellaneous
Is not inhibited by the gamma-phospholipase A2 inhibitor (PLI) CgMIP-I (AC P0DQP7) and by the alpha-PLI CgMIP-II (AC P0DQP8).1 Publication
Caution
Does not bind calcium as one of the calcium-binding sites is lost (Asp->Lys in position 48, which corresponds to 'Lys-49' in the current nomenclature).Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 105 | Important residue of the cationic membrane-docking site (MDoS)By similarity | 1 | |
Sitei | 108 | Important residue of the cationic membrane-docking site (MDoS)By similarity | 1 | |
Sitei | 112 | Cationic membrane-docking site (MDoS)By similarity | 1 | |
Sitei | 114 | Hydrophobic membrane-disruption site (MDiS)By similarity | 1 | |
Sitei | 117 | Cationic membrane-docking site (MDoS)By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Myotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 homolog GodMT-II1 PublicationShort name: svPLA2 homolog Alternative name(s): Myotoxin II1 Publication |
Organismi | Cerrophidion godmani (Porthidium godmani) (Bothrops godmani) |
Taxonomic identifieri | 44722 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Cerrophidion |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 4.2 µg/g by intravenous injection into mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161640 | 1 – 121 | Basic phospholipase A2 homolog GodMT-II1 PublicationAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 115 | Combined sources1 Publication | ||
Disulfide bondi | 28 ↔ 44 | Combined sources1 Publication | ||
Disulfide bondi | 43 ↔ 95 | Combined sources1 Publication | ||
Disulfide bondi | 49 ↔ 121 | Combined sources1 Publication | ||
Disulfide bondi | 50 ↔ 88 | Combined sources1 Publication | ||
Disulfide bondi | 57 ↔ 81 | Combined sources1 Publication | ||
Disulfide bondi | 75 ↔ 86 | Combined sources1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.2 Publications
Interactioni
Subunit structurei
Monomer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P81165 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P81165 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 117 | Important for membrane-damaging activities in eukaryotes and bacteria; heparin-bindingBy similarityAdd BLAST | 13 |
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P81165-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SMYQLWKMIL QETGKNAVPS YGLYGCNCGV GSRGKPKDAT DRCCFVHKCC
60 70 80 90 100
YKKLTDCSPK TDSYSYSWKD KTIVCGDNNP CLQEMCECDK AVAICLRENL
110 120
DTYNKNYKIY PKPLCKKADA C
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GOD | X-ray | 2.80 | A | 1-111 | [»] | |
SMRi | P81165 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P81165 |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2H2_CERGO | |
Accessioni | P81165Primary (citable) accession number: P81165 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | June 2, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families