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Entry version 159 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Insulin receptor substrate 2

Gene

Irs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate the control of various cellular processes by insulin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-109704 PI3K Cascade
R-MMU-112399 IRS-mediated signalling
R-MMU-112412 SOS-mediated signalling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1266695 Interleukin-7 signaling
R-MMU-198203 PI3K/AKT activation
R-MMU-2428928 IRS-related events triggered by IGF1R
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-8853659 RET signaling
R-MMU-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-MMU-9027284 Erythropoietin activates RAS

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin receptor substrate 2
Short name:
IRS-2
Alternative name(s):
4PS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Irs2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109334 Irs2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842401 – 1321Insulin receptor substrate 2Add BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei303PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei347PhosphothreonineBy similarity1
Modified residuei362PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei385PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1
Modified residuei409Omega-N-methylarginineBy similarity1
Modified residuei517PhosphothreonineBy similarity1
Modified residuei520PhosphoserineBy similarity1
Modified residuei524PhosphothreonineCombined sources1
Modified residuei536Phosphotyrosine; by INSRBy similarity1
Modified residuei556PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1
Modified residuei575PhosphothreonineBy similarity1
Modified residuei576PhosphothreonineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1
Modified residuei616PhosphoserineBy similarity1
Modified residuei649PhosphotyrosineCombined sources1
Modified residuei671Phosphotyrosine; by INSRBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei678PhosphoserineBy similarity1
Modified residuei727PhosphoserineBy similarity1
Modified residuei728PhosphoserineCombined sources1
Modified residuei762PhosphoserineBy similarity1
Modified residuei771PhosphothreonineBy similarity1
Modified residuei796PhosphoserineBy similarity1
Modified residuei819PhosphoserineBy similarity1
Modified residuei907PhosphoserineCombined sources1
Modified residuei911Phosphotyrosine; by INSRBy similarity1
Modified residuei965PhosphoserineBy similarity1
Modified residuei970Phosphotyrosine; by INSRBy similarity1
Modified residuei1071PhosphothreonineBy similarity1
Modified residuei1089PhosphoserineBy similarity1
Modified residuei1148PhosphothreonineBy similarity1
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1163PhosphoserineBy similarity1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1175PhosphoserineBy similarity1
Modified residuei1190PhosphoserineBy similarity1
Modified residuei1242Phosphotyrosine; by INSRBy similarity1
Modified residuei1303Phosphotyrosine; by INSRBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P81122

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P81122

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P81122

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P81122

PeptideAtlas

More...
PeptideAtlasi
P81122

PRoteomics IDEntifications database

More...
PRIDEi
P81122

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P81122

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P81122

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle, lung, brain, liver, kidney, heart and spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038894 Expressed in 173 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P81122 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHIP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
239306, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-39500N

Protein interaction database and analysis system

More...
IntActi
P81122, 7 interactors

Molecular INTeraction database

More...
MINTi
P81122

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038514

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P81122

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P81122

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 144PHPROSITE-ProRule annotationAdd BLAST129
Domaini191 – 295IRS-type PTBPROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi536 – 539YXXM motif 14
Motifi594 – 597YXXM motif 24
Motifi649 – 652YXXM motif 34
Motifi671 – 674YXXM motif 44
Motifi734 – 737YXXM motif 54
Motifi814 – 817YXXM motif 64
Motifi1061 – 1064YXXM motif 74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 28Poly-Asn10
Compositional biasi444 – 449Poly-Ser6
Compositional biasi638 – 641Poly-Ser4
Compositional biasi936 – 939Poly-Ser4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXEK Eukaryota
ENOG410Z9EP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P81122

KEGG Orthology (KO)

More...
KOi
K07187

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKAPYTC

Database of Orthologous Groups

More...
OrthoDBi
298675at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325994

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01204 PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10614 PTHR10614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00628 INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P81122-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAPLPGPP ASAGGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL
60 70 80 90 100
RGPGTGGDEA SAAGGSPPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN
110 120 130 140 150
INKRADAKHK YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRSGE
160 170 180 190 200
GGSGTTGGSC SASLPGVLGG SAGAAGCDDN YGLVTPATAV YREVWQVNLK
210 220 230 240 250
PKGLGQSKNL TGVYRLCLSA RTIGFVKLNC EQPSVTLQLM NIRRCGHSDS
260 270 280 290 300
FFFIEVGRSA VTGPGELWMQ ADDSVVAQNI HETILEAMKA LKELFEFRPR
310 320 330 340 350
SKSQSSGSSA THPISVPGAR RHHHLVNLPP SQTGLVRRSR TDSLAATPPA
360 370 380 390 400
AKCTSCRVRT ASEGDGGAAG GAGTAGGRPM SVAGSPLSPG PVRAPLSRSH
410 420 430 440 450
TLSAGCGGRP SKVTLAPAGG ALQHSRSMSM PVAHSPPAAT SPGSLSSSSG
460 470 480 490 500
HGSGSYPLPP GSHPHLPHPL HHPQGQRPSS GSASASGSPS DPGFMSLDEY
510 520 530 540 550
GSSPGDLRAF SSHRSNTPES IAETPPARDG SGGELYGYMS MDRPLSHCGR
560 570 580 590 600
PYRRVSGDGA QDLDRGLRKR TYSLTTPARQ RQVPQPSSAS LDEYTLMRAT
610 620 630 640 650
FSGSSGRLCP SFPASSPKVA YNPYPEDYGD IEIGSHKSSS SNLGADDGYM
660 670 680 690 700
PMTPGAALRS GGPNSCKSDD YMPMSPTSVS APKQILQPRL AAALPPSGAA
710 720 730 740 750
VPAPPSGVGR TFPVNGGGYK ASSPAESSPE DSGYMRMWCG SKLSMENPDP
760 770 780 790 800
KLLPNGDYLN MSPSEAGTAG TPPDFSAALR GGSEGLKGIP GHCYSSLPRS
810 820 830 840 850
YKAPCSCSGD NDQYVLMSSP VGRILEEERL EPQATPGAGT FGAAGGSHTQ
860 870 880 890 900
PHHSAVPSSM RPSAIGGRPE GFLGQRCRAV RPTRLSLEGL QTLPSMQEYP
910 920 930 940 950
LPTEPKSPGE YINIDFGEAG TRLSPPAPPL LASAASSSSL LSASSPASSL
960 970 980 990 1000
GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPSTRSGDT VGSMDGLLSP
1010 1020 1030 1040 1050
EASSPYPPLP PRPSTSPSSL QQPLPPAPGD LYRLPPASAA TSQGPTAGSS
1060 1070 1080 1090 1100
MSSEPGDNGD YTEMAFGVAA TPPQPIVAPP KPEGARVASP TSGLKRLSLM
1110 1120 1130 1140 1150
DQVSGVEAFL QVSQPPDPHR GAKVIRADPQ GGRRRHSSET FSSTTTVTPV
1160 1170 1180 1190 1200
SPSFAHNSKR HNSASVENVS LRKSSEGSST LGGGDEPPTS PGQAQPLVAV
1210 1220 1230 1240 1250
PPVPQARPWN PGQPGALIGC PGGSSSPMRR ETSVGFQNGL NYIAIDVRGE
1260 1270 1280 1290 1300
QGSLAQSQPQ PGDKNSWSRT RSLGGLLGTV GGSGASGVCG GPGTGALPSA
1310 1320
STYASIDFLS HHLKEATVVK E
Length:1,321
Mass (Da):136,763
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i823A5458DA21C9C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13A → G no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti232Q → G no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti240M → N no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti428M → N no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti761M → K no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti916F → P no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti975F → P no nucleotide entry (PubMed:7675087).Curated1
Sequence conflicti1062T → S no nucleotide entry (PubMed:7675087).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC147580 mRNA Translation: AAI47581.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52477.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074681.1, NM_001081212.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040514; ENSMUSP00000038514; ENSMUSG00000038894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
384783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:384783

UCSC genome browser

More...
UCSCi
uc009kuz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147580 mRNA Translation: AAI47581.1
CCDSiCCDS52477.1
RefSeqiNP_001074681.1, NM_001081212.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BU3X-ray1.65B620-634[»]
3BU5X-ray2.10B620-634[»]
3BU6X-ray1.95B620-634[»]
SMRiP81122
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi239306, 3 interactors
DIPiDIP-39500N
IntActiP81122, 7 interactors
MINTiP81122
STRINGi10090.ENSMUSP00000038514

PTM databases

iPTMnetiP81122
PhosphoSitePlusiP81122

Proteomic databases

EPDiP81122
jPOSTiP81122
MaxQBiP81122
PaxDbiP81122
PeptideAtlasiP81122
PRIDEiP81122

Genome annotation databases

EnsembliENSMUST00000040514; ENSMUSP00000038514; ENSMUSG00000038894
GeneIDi384783
KEGGimmu:384783
UCSCiuc009kuz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8660
MGIiMGI:109334 Irs2

Phylogenomic databases

eggNOGiENOG410IXEK Eukaryota
ENOG410Z9EP LUCA
GeneTreeiENSGT00940000161407
HOGENOMiHOG000113103
InParanoidiP81122
KOiK07187
OMAiYKAPYTC
OrthoDBi298675at2759
TreeFamiTF325994

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-112399 IRS-mediated signalling
R-MMU-112412 SOS-mediated signalling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1266695 Interleukin-7 signaling
R-MMU-198203 PI3K/AKT activation
R-MMU-2428928 IRS-related events triggered by IGF1R
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-8853659 RET signaling
R-MMU-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-MMU-9027284 Erythropoietin activates RAS

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Irs2 mouse
EvolutionaryTraceiP81122

Protein Ontology

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PROi
PR:P81122

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038894 Expressed in 173 organ(s), highest expression level in blood
GenevisibleiP81122 MM

Family and domain databases

CDDicd01204 PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10614 PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00628 INSULINRSI
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P81122
Secondary accession number(s): B9EJW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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