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Protein

Allograft inflammatory factor 1

Gene

AIF1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi57 – 681PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi93 – 1042PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1
Short name:
AIF-1
Alternative name(s):
Daintain
Gene namesi
Name:AIF1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738681 – 146Allograft inflammatory factor 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei38PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP81076
PeptideAtlasiP81076
PRIDEiP81076

PTM databases

iPTMnetiP81076

Expressioni

Tissue specificityi

Microglial cells in the central nervous system and dendritic cells and macrophages in several organs.

Interactioni

Subunit structurei

Homodimer (Potential). Monomer. Interacts with LCP1 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001497

Structurei

3D structure databases

ProteinModelPortaliP81076
SMRiP81076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 79EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 115EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410INJA Eukaryota
ENOG411206J LUCA
HOVERGENiHBG004002
InParanoidiP81076

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequencei

Sequence statusi: Complete.

P81076-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SETIDLQGGK AFGLLKAQQE GRLNEINKQF LDDPKYSSDE DLSRKLEAFK
60 70 80 90 100
QKYMEFDLNG NGDIDIMSLK RMLEKLGVPK THLELKKLIK EVSSGSGETF
110 120 130 140
SYSIFLKMML GKRSAILKMI LMYEEKAREQ EKPTGPPAKK AISELP
Length:146
Mass (Da):16,560
Last modified:July 15, 1998 - v1
Checksum:i018FD1D8698E86EF
GO

Sequence databases

UniGeneiSsc.455

Similar proteinsi

Cross-referencesi

Sequence databases

UniGeneiSsc.455

3D structure databases

ProteinModelPortaliP81076
SMRiP81076
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001497

PTM databases

iPTMnetiP81076

Proteomic databases

PaxDbiP81076
PeptideAtlasiP81076
PRIDEiP81076

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410INJA Eukaryota
ENOG411206J LUCA
HOVERGENiHBG004002
InParanoidiP81076

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIF1_PIG
AccessioniPrimary (citable) accession number: P81076
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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