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Protein

Immunoglobulin lambda variable 3-21

Gene

IGLV3-21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).4 Publications

Caution

For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.Curated

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DBIGLV3-21

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda variable 3-212 Publications
Alternative name(s):
Ig lambda chain V-III region LOI1 Publication
Ig lambda chain V-V region DEL1 Publication
Ig lambda chain V-VII region MOT1 Publication
Gene namesi
Name:IGLV3-212 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000211662.2
HGNCiHGNC:5905 IGLV3-21
neXtProtiNX_P80748

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi28796
OpenTargetsiENSG00000211662

Polymorphism and mutation databases

DMDMi126571
126577
6016518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000005984318 – 117Immunoglobulin lambda variable 3-211 PublicationAdd BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 106PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP80748
PRIDEiP80748
ProteomicsDBi51447
51448
57690

Expressioni

Gene expression databases

BgeeiENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP80748
SMRiP80748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – ›117Ig-likePROSITE-ProRule annotationAdd BLAST›100

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00900000140816
HOVERGENiHBG018013
OMAiNKYVHWY
PhylomeDBiP80748

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80748-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS
60 70 80 90 100
VHWYQQKPGQ APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVEAGD
110
EADYYCQVWD SSSDHPT
Length:117
Mass (Da):12,446
Last modified:November 2, 2016 - v2
Checksum:iB678ABFF5F22FDED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 22SYV → FYE AA sequence (PubMed:6780787).Curated3
Sequence conflicti24T → S AA sequence (PubMed:4452363).Curated1
Sequence conflicti31 – 33VAP → LAA AA sequence (PubMed:6780787).Curated3
Sequence conflicti35Q → E AA sequence (PubMed:10510403).Curated1
Sequence conflicti38R → M AA sequence (PubMed:6780787).Curated1
Sequence conflicti39I → L AA sequence (PubMed:10510403).Curated1
Sequence conflicti42G → E AA sequence (PubMed:6780787).Curated1
Sequence conflicti45N → D AA sequence (PubMed:10510403).Curated1
Sequence conflicti45N → D AA sequence (PubMed:4452363).Curated1
Sequence conflicti45N → D AA sequence (PubMed:6780787).Curated1
Sequence conflicti45N → G AA sequence (PubMed:4452363).Curated1
Sequence conflicti48 – 49SK → ER AA sequence (PubMed:6780787).Curated2
Sequence conflicti48S → G AA sequence (PubMed:4452363).Curated1
Sequence conflicti49K → E AA sequence (PubMed:10510403).Curated1
Sequence conflicti64 – 66LVV → PVI AA sequence (PubMed:6780787).Curated3
Sequence conflicti66 – 70VYDDS → IYFDR AA sequence (PubMed:10510403).Curated5
Sequence conflicti67 – 74YDDSDRPS → HEDNDRPA AA sequence (PubMed:4452363).Curated8
Sequence conflicti70S → A AA sequence (PubMed:6780787).Curated1
Sequence conflicti76 – 78IPE → VPA AA sequence (PubMed:6780787).Curated3
Sequence conflicti83S → Y AA sequence (PubMed:6780787).Curated1
Sequence conflicti88T → S AA sequence (PubMed:6780787).Curated1
Sequence conflicti90T → A AA sequence (PubMed:4452363).Curated1
Sequence conflicti90T → I AA sequence (PubMed:4452363).Curated1
Sequence conflicti94S → N AA sequence (PubMed:6780787).Curated1
Sequence conflicti105Y → F AA sequence (PubMed:6780787).Curated1
Sequence conflicti107Q → E AA sequence (PubMed:4452363).Curated1
Sequence conflicti108V → L AA sequence (PubMed:10510403).Curated1
Sequence conflicti108V → S AA sequence (PubMed:6780787).Curated1
Sequence conflicti111 – 117SSSDHPT → DRTAHVV AA sequence (PubMed:4452363).Curated7
Sequence conflicti111 – 117SSSDHPT → NGSYEVV AA sequence (PubMed:6780787).Curated7
Sequence conflicti114 – 117DHPT → EHVV AA sequence (PubMed:10510403).Curated4
Non-terminal residuei1171

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGLV3-21*02.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244250 Genomic DNA No translation available.
PIRiA01985 L5HUDL
A01986 L7HUMT
UniGeneiHs.449585
Hs.625768

Genome annotation databases

EnsembliENST00000390308; ENSP00000374843; ENSG00000211662

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244250 Genomic DNA No translation available.
PIRiA01985 L5HUDL
A01986 L7HUMT
UniGeneiHs.449585
Hs.625768

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LOImodel-A/B21-117[»]
ProteinModelPortaliP80748
SMRiP80748
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGT/GENE-DBIGLV3-21

Polymorphism and mutation databases

DMDMi126571
126577
6016518

Proteomic databases

PeptideAtlasiP80748
PRIDEiP80748
ProteomicsDBi51447
51448
57690

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390308; ENSP00000374843; ENSG00000211662

Organism-specific databases

DisGeNETi28796
EuPathDBiHostDB:ENSG00000211662.2
GeneCardsiIGLV3-21
HGNCiHGNC:5905 IGLV3-21
neXtProtiNX_P80748
OpenTargetsiENSG00000211662
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00900000140816
HOVERGENiHBG018013
OMAiNKYVHWY
PhylomeDBiP80748

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

PROiPR:P80748

Gene expression databases

BgeeiENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLV321_HUMAN
AccessioniPrimary (citable) accession number: P80748
Secondary accession number(s): A0A075B6J7, P01719, P01720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2016
Last modified: September 12, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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