IGLV3-21

Functionⁱ

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).4 Publications

Caution

For an example of a full-length immunoglobulin lambda light chain see AC P0DOX8.Curated

GO - Molecular functionⁱ

antigen binding
Source: UniProtKB
Non-traceable author statementⁱ
serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation Source: Reactome
complement activation, classical pathway Source: Reactome
Fc-epsilon receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
leukocyte migration Source: Reactome
receptor-mediated endocytosis Source: Reactome
regulation of complement activation Source: Reactome
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGLV3-21

IMGT/GENE-DB

IGLV3-21

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin lambda variable 3-212 Publications Alternative name(s): Ig lambda chain V-III region LOI1 Publication Ig lambda chain V-V region DEL1 Publication Ig lambda chain V-VII region MOT1 Publication
Gene namesⁱ	Name:IGLV3-212 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211662.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5905 IGLV3-21
neXtProtⁱ	NX_P80748

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28796
Open Targets More...OpenTargetsⁱ	ENSG00000211662

Polymorphism and mutation databases

DMDMⁱ	126571 126577 6016518

DMDMⁱ

126571
126577
6016518

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	1 PublicationAdd BLAST		17
ChainⁱPRO_0000059843	18 – 117	Immunoglobulin lambda variable 3-211 PublicationAdd BLAST		100

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	41 ↔ 106	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P80748
PRIDEⁱ	P80748
ProteomicsDBⁱ	51447 51448 57690

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P80748
SMRⁱ	P80748
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – ›117	Ig-likePROSITE-ProRule annotationAdd BLAST		›100

Keywords - Domainⁱ

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140816
HOVERGENⁱ	HBG018013
OMAⁱ	NKYVHWY
PhylomeDBⁱ	P80748

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P80748-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS 
        60         70         80         90        100
VHWYQQKPGQ APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVEAGD 
       110 
EADYYCQVWD SSSDHPT

Length:117

Mass (Da):12,446

Last modified:November 2, 2016 - v2

Checksum:ⁱB678ABFF5F22FDED

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	20 – 22	SYV → FYE AA sequence (PubMed:6780787).Curated	3
Sequence conflictⁱ	24	T → S AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	31 – 33	VAP → LAA AA sequence (PubMed:6780787).Curated	3
Sequence conflictⁱ	35	Q → E AA sequence (PubMed:10510403).Curated	1
Sequence conflictⁱ	38	R → M AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	39	I → L AA sequence (PubMed:10510403).Curated	1
Sequence conflictⁱ	42	G → E AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	45	N → D AA sequence (PubMed:10510403).Curated	1
Sequence conflictⁱ	45	N → D AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	45	N → D AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	45	N → G AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	48 – 49	SK → ER AA sequence (PubMed:6780787).Curated	2
Sequence conflictⁱ	48	S → G AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	49	K → E AA sequence (PubMed:10510403).Curated	1
Sequence conflictⁱ	64 – 66	LVV → PVI AA sequence (PubMed:6780787).Curated	3
Sequence conflictⁱ	66 – 70	VYDDS → IYFDR AA sequence (PubMed:10510403).Curated	5
Sequence conflictⁱ	67 – 74	YDDSDRPS → HEDNDRPA AA sequence (PubMed:4452363).Curated	8
Sequence conflictⁱ	70	S → A AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	76 – 78	IPE → VPA AA sequence (PubMed:6780787).Curated	3
Sequence conflictⁱ	83	S → Y AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	88	T → S AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	90	T → A AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	90	T → I AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	94	S → N AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	105	Y → F AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	107	Q → E AA sequence (PubMed:4452363).Curated	1
Sequence conflictⁱ	108	V → L AA sequence (PubMed:10510403).Curated	1
Sequence conflictⁱ	108	V → S AA sequence (PubMed:6780787).Curated	1
Sequence conflictⁱ	111 – 117	SSSDHPT → DRTAHVV AA sequence (PubMed:4452363).Curated	7
Sequence conflictⁱ	111 – 117	SSSDHPT → NGSYEVV AA sequence (PubMed:6780787).Curated	7
Sequence conflictⁱ	114 – 117	DHPT → EHVV AA sequence (PubMed:10510403).Curated	4
Non-terminal residueⁱ	117		1

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGLV3-21*02.

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC244250 Genomic DNA No translation available.
PIRⁱ	A01985 L5HUDL A01986 L7HUMT
UniGeneⁱ	Hs.449585 Hs.625768

Genome annotation databases

Ensemblⁱ	ENST00000390308; ENSP00000374843; ENSG00000211662

Ensemblⁱ

ENST00000390308; ENSP00000374843; ENSG00000211662

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P80748	IGLV3-21 isoform 1 (Fragment)		PANTR		117	UniRef90_P80748
IGLV3-21 isoform 1 (Fragment)		PONAB		101

Protein	Similar proteins		Species	Score	Length	Source
P80748	Immunoglobulin lambda variable 3-12		HUMAN		115	UniRef50_P80748
IGLV3-21 isoform 1 (Fragment)		PANTR		117
IGLV3-21 isoform 1 (Fragment)		PONAB		101
Uncharacterized protein (Fragment)		wild yak		117
Uncharacterized protein		SHEEP		110
+106

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC244250 Genomic DNA No translation available.
PIRⁱ	A01985 L5HUDL A01986 L7HUMT
UniGeneⁱ	Hs.449585 Hs.625768

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LOI	model	-	A/B	21-117	[»]
ProteinModelPortalⁱ	P80748
SMRⁱ	P80748
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

IMGT/GENE-DB	IGLV3-21

IMGT/GENE-DB

IGLV3-21

Polymorphism and mutation databases

DMDMⁱ	126571 126577 6016518

DMDMⁱ

126571
126577
6016518

Proteomic databases

PeptideAtlasⁱ	P80748
PRIDEⁱ	P80748
ProteomicsDBⁱ	51447 51448 57690

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000390308; ENSP00000374843; ENSG00000211662

Ensemblⁱ

ENST00000390308; ENSP00000374843; ENSG00000211662

Organism-specific databases

DisGeNETⁱ	28796
EuPathDBⁱ	HostDB:ENSG00000211662.2
GeneCardsⁱ	IGLV3-21
HGNCⁱ	HGNC:5905 IGLV3-21
neXtProtⁱ	NX_P80748
OpenTargetsⁱ	ENSG00000211662
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00900000140816
HOVERGENⁱ	HBG018013
OMAⁱ	NKYVHWY
PhylomeDBⁱ	P80748

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P80748

PROⁱ

PR:P80748

Gene expression databases

Bgeeⁱ	ENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSG00000211662 Expressed in 82 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LV321_HUMAN
Accessionⁱ	P80748Primary (citable) accession number: P80748 Secondary accession number(s): A0A075B6J7, P01719, P01720
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	November 2, 2016
	Last modified:	September 12, 2018
	This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P80748 (LV321_HUMAN)

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Immunoglobulin lambda variable 3-21

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ