Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain acid soluble protein 1

Gene

BASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Protein family/group databases

TCDBi1.A.71.1.1 the brain acid-soluble protein channel (basp1 channel) family

Names & Taxonomyi

Protein namesi
Recommended name:
Brain acid soluble protein 1
Alternative name(s):
22 kDa neuronal tissue-enriched acidic protein
Neuronal axonal membrane protein NAP-22
Gene namesi
Name:BASP1
Synonyms:NAP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000176788.8
HGNCiHGNC:957 BASP1
MIMi605940 gene
neXtProtiNX_P80723

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10409
OpenTargetsiENSG00000176788
PharmGKBiPA25261

Polymorphism and mutation databases

DMDMi6686256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001428952 – 227Brain acid soluble protein 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei31PhosphothreonineCombined sources1
Modified residuei36PhosphothreonineCombined sources1
Modified residuei40PhosphoserineBy similarity1
Cross-linki84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei164PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP80723
MaxQBiP80723
PaxDbiP80723
PeptideAtlasiP80723
PRIDEiP80723
ProteomicsDBi57688
57689 [P80723-2]
TopDownProteomicsiP80723-1 [P80723-1]
P80723-2 [P80723-2]

PTM databases

iPTMnetiP80723
PhosphoSitePlusiP80723
SwissPalmiP80723

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000176788
CleanExiHS_BASP1
ExpressionAtlasiP80723 baseline and differential
GenevisibleiP80723 HS

Organism-specific databases

HPAiHPA045218
HPA050333

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115680, 61 interactors
IntActiP80723, 42 interactors
STRINGi9606.ENSP00000319281

Structurei

3D structure databases

DisProtiDP00930
ProteinModelPortaliP80723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BASP1 family.Curated

Phylogenomic databases

eggNOGiENOG410J14G Eukaryota
ENOG4112CMG LUCA
GeneTreeiENSGT00730000111450
HOGENOMiHOG000095176
InParanoidiP80723
KOiK17272
OMAiTNSDQTI
OrthoDBiEOG091G10E1

Family and domain databases

InterProiView protein in InterPro
IPR008408 BASP1
PANTHERiPTHR23212 PTHR23212, 1 hit
PfamiView protein in Pfam
PF05466 BASP1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P80723-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGKLSKKKK GYNVNDEKAK EKDKKAEGAA TEEEGTPKES EPQAAAEPAE
60 70 80 90 100
AKEGKEKPDQ DAEGKAEEKE GEKDAAAAKE EAPKAEPEKT EGAAEAKAEP
110 120 130 140 150
PKAPEQEQAA PGPAAGGEAP KAAEAAAAPA ESAAPAAGEE PSKEEGEPKK
160 170 180 190 200
TEAPAAPAAQ ETKSDGAPAS DSKPGSSEAA PSSKETPAAT EAPSSTPKAQ
210 220
GPAASAEEPK PVEAPAANSD QTVTVKE
Length:227
Mass (Da):22,693
Last modified:January 23, 2007 - v2
Checksum:i56FFFCEA441062AB
GO
Isoform 2 (identifier: P80723-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-141: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):17,664
Checksum:i562F9FC9D05A565C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → P in AAC67374 (PubMed:9749536).Curated1
Sequence conflicti114 – 115AA → LR in AAC67374 (PubMed:9749536).Curated2
Sequence conflicti128 – 132APAES → GPRPR in AAC67374 (PubMed:9749536).Curated5
Sequence conflicti152E → G in AAH00518 (PubMed:15489334).Curated1

Mass spectrometryi

Molecular mass is 22780 Da from positions 2 - 227. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04839676A → V. Corresponds to variant dbSNP:rs3733748Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03799488 – 141Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039656 mRNA Translation: AAC67374.1
BT019340 mRNA Translation: AAV38147.1
BT019341 mRNA Translation: AAV38148.1
AK295995 mRNA Translation: BAG58770.1
CH471102 Genomic DNA Translation: EAX08012.1
CH471102 Genomic DNA Translation: EAX08013.1
BC000518 mRNA Translation: AAH00518.1
CCDSiCCDS3888.1 [P80723-1]
RefSeqiNP_001258535.1, NM_001271606.1 [P80723-1]
NP_006308.3, NM_006317.4 [P80723-1]
UniGeneiHs.201641
Hs.646924

Genome annotation databases

EnsembliENST00000322611; ENSP00000319281; ENSG00000176788 [P80723-1]
ENST00000616743; ENSP00000482066; ENSG00000176788 [P80723-1]
GeneIDi10409
KEGGihsa:10409
UCSCiuc003jfx.5 human [P80723-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBASP1_HUMAN
AccessioniPrimary (citable) accession number: P80723
Secondary accession number(s): B4DJA8
, D3DTD5, O43596, Q5U0S0, Q9BWA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health