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Protein

Potassium channel toxin alpha-KTx 6.2

Gene
N/A
Organism
Scorpio palmatus (Israeli golden scorpion) (Scorpio maurus palmatus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC50=0.12-0.8 nM), KCa3.1/KCNN4 (IC50=1-2.2 nM), Shaker B (IC50=2.39-80 nM), Kv1.1/KCNA1 (IC50=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC50=150-180 or no activity, depending on the study).7 Publications

Miscellaneous

Shows very weak or no activity on KCa1.1/KCNMA1, KCa2.1/KCNN1, KCa2.2/KCNN2, KCa2.3/KCNN3, Kir2.3/KCNJ4.3 Publications

Caution

Has not the same disulfide pairing as other members of alpha-KTx 6.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei23Basic residue of the functional dyad, critical for activity1 Publication1
Sitei32Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 6.2
Alternative name(s):
Maurotoxin1 Publication
Short name:
MTX1 Publication
OrganismiScorpio palmatus (Israeli golden scorpion) (Scorpio maurus palmatus)
Taxonomic identifieri1662106 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeScorpio

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 4 µg/kg by intracerebroventricular injection into mice.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15K → Q: Induces a change in the third and fourth disulfide bonds, leading to disulfide bonds between C-13 and C-31, and C-19 and C-34. 1 Publication1
Mutagenesisi23K → A: 1000-fold decrease in affinity for shaker B. 1 Publication1
Mutagenesisi33G → A: Induces a change in the third and fourth disulfide bonds, leading to disulfide bonds between C-13 and C-31, and C-19 and C-34. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449291 – 34Potassium channel toxin alpha-KTx 6.2Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 245 PublicationsImported
Disulfide bondi9 ↔ 295 PublicationsImported
Disulfide bondi13 ↔ 195 PublicationsImported
Disulfide bondi31 ↔ 345 PublicationsImported
Modified residuei34Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80719
SMRiP80719
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80719

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P80719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
VSCTGSKDCY APCRKQTGCP NAKCINKSCK CYGC
Length:34
Mass (Da):3,621
Last modified:November 1, 1997 - v1
Checksum:iFB0BE07370536A48
GO

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXMNMR-A1-34[»]
1WPDNMR-A1-16[»]
1WT7NMR-A3-34[»]
ProteinModelPortaliP80719
SMRiP80719
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80719

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAX62_SCOPA
AccessioniPrimary (citable) accession number: P80719
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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