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Protein

Thioredoxin

Gene

trxA

Organism
Alicyclobacillus acidocaldarius (Bacillus acidocaldarius)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Gene namesi
Name:trxA
OrganismiAlicyclobacillus acidocaldarius (Bacillus acidocaldarius)
Taxonomic identifieri1388 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200721 – 105ThioredoxinAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32Redox-activePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Turni7 – 9Combined sources3
Helixi10 – 14Combined sources5
Beta strandi15 – 18Combined sources4
Beta strandi20 – 25Combined sources6
Helixi30 – 45Combined sources16
Turni47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Turni57 – 59Combined sources3
Helixi61 – 66Combined sources6
Beta strandi71 – 79Combined sources9
Beta strandi82 – 89Combined sources8
Helixi93 – 99Combined sources7
Turni100 – 104Combined sources5

3D structure databases

ProteinModelPortaliP80579
SMRiP80579
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80579

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 105ThioredoxinPROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63 Bacteria
COG0526 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P80579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATMTLTDANF QQAIQGDKPV LVDFWAAWCG PCRMMAPVLE EFAEAHADKV
60 70 80 90 100
TVAKLNVDEN PETTSQFGIM SIPTLILFKG GRPVKQLIGY QPKEQLEAQL

ADVLQ
Length:105
Mass (Da):11,576
Last modified:October 1, 1996 - v1
Checksum:iE03F636DFB3C3745
GO

Mass spectrometryi

Molecular mass is 11577 Da from positions 1 - 105. Determined by ESI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiTHIO_ALIAC
AccessioniPrimary (citable) accession number: P80579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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