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UniProtKB - P80511 (S10AC_HUMAN)

Entry version 188 (10 Feb 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Protein S100-A12

Gene

S100A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi16Zinc or copper1
Metal bindingi26Zinc or copper1
Metal bindingi86Zinc or copper1
Metal bindingi90Zinc or copper1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi19 – 321; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi62 – 732; high affinityPROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
Biological processImmunity, Inflammatory response, Innate immunity
LigandCalcium, Copper, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P80511

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6798695, Neutrophil degranulation
R-HSA-879415, Advanced glycosylation endproduct receptor signaling
R-HSA-933542, TRAF6 mediated NF-kB activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein S100-A12
Alternative name(s):
CGRP
Calcium-binding protein in amniotic fluid 1
Short name:
CAAF1
Calgranulin-C
Short name:
CAGC
Extracellular newly identified RAGE-binding protein
Short name:
EN-RAGE
Migration inhibitory factor-related protein 6
Short name:
MRP-6
Short name:
p6
Neutrophil S100 protein
S100 calcium-binding protein A12
Cleaved into the following chain:
Calcitermin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S100A12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10489, S100A12

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603112, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P80511

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163221.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6283

Open Targets

More...OpenTargetsi		ENSG00000163221

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34901

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P80511, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01025, Amlexanox
DB00768, Olopatadine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		S100A12

Domain mapping of disease mutations (DMDM)

More...DMDMi		2507565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved4 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000453832 – 92Protein S100-A12Add BLAST91
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000477478 – 92CalciterminAdd BLAST15

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1154

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P80511

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P80511

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P80511

PeptideAtlas

More...PeptideAtlasi		P80511

PRoteomics IDEntifications database

More...PRIDEi		P80511

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57687

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P80511

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P80511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P80511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163221, Expressed in bone marrow and 165 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P80511, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163221, Group enriched (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions.

Interacts with AGER and both calcium and zinc are essential for the interaction.

Interacts with CACYBP in a calcium-dependent manner.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112191, 1 interactor

Protein interaction database and analysis system

More...IntActi		P80511, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357726

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P80511, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P80511

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P80511

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P80511

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 53Hinge domainAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hinge domain contributes significantly to its chemotactic properties.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SA01, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_138624_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P80511

Identification of Orthologs from Complete Genome Data

More...OMAi		HMEGIIN

Database of Orthologous Groups

More...OrthoDBi		1521098at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P80511

TreeFam database of animal gene trees

More...TreeFami		TF332727

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR001751, S100/CaBP-9k_CS
IPR013787, S100_Ca-bd_sub

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01023, S_100, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01394, S_100, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS00303, S100_CABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P80511-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKLEEHLEG IVNIFHQYSV RKGHFDTLSK GELKQLLTKE LANTIKNIKD 
        60         70         80         90 
KAVIDEIFQG LDANQDEQVD FQEFISLVAI ALKAAHYHTH KE
Length:92
Mass (Da):10,575
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52AF75A31BDC222A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7H → V AA sequence (PubMed:1860454).Curated1
Sequence conflicti12 – 13VN → YS AA sequence (PubMed:1860454).Curated2
Sequence conflicti16H → F AA sequence (PubMed:1860454).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 10444 Da. Determined by ESI. 1 Publication
Molecular mass is 1688.9 Da. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D49549 mRNA Translation: BAA08497.1
D83657 Genomic DNA Translation: BAA12030.1
D83664 mRNA Translation: BAA12036.1
X97859 mRNA Translation: CAA66453.1
X98289, X98290 Genomic DNA Translation: CAB94792.1
AL591704 Genomic DNA No translation available.
BC070294 mRNA Translation: AAH70294.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1037.1

Protein sequence database of the Protein Information Resource

More...PIRi		A61522
JC4712

NCBI Reference Sequences

More...RefSeqi		NP_005612.1, NM_005621.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368737; ENSP00000357726; ENSG00000163221

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6283

UCSC genome browser

More...UCSCi		uc001fbr.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49549 mRNA Translation: BAA08497.1
D83657 Genomic DNA Translation: BAA12030.1
D83664 mRNA Translation: BAA12036.1
X97859 mRNA Translation: CAA66453.1
X98289, X98290 Genomic DNA Translation: CAB94792.1
AL591704 Genomic DNA No translation available.
BC070294 mRNA Translation: AAH70294.1
CCDSiCCDS1037.1
PIRiA61522
JC4712
RefSeqiNP_005612.1, NM_005621.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E8AX-ray1.95A/B2-92[»]
1GQMX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-92[»]
1ODBX-ray2.19A/B/C/D/E/F2-92[»]
2M9GNMR-A/B1-92[»]
2WC8X-ray1.88A/B/C/D2-92[»]
2WCBX-ray1.73A/B2-92[»]
2WCEX-ray1.77A/B2-92[»]
2WCFX-ray2.78A/B/C/D/E/F2-92[»]
BMRBiP80511
SMRiP80511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112191, 1 interactor
IntActiP80511, 3 interactors
STRINGi9606.ENSP00000357726

Chemistry databases

DrugBankiDB01025, Amlexanox
DB00768, Olopatadine

PTM databases

iPTMnetiP80511
PhosphoSitePlusiP80511

Genetic variation databases

BioMutaiS100A12
DMDMi2507565

Proteomic databases

CPTACinon-CPTAC-1154
jPOSTiP80511
MassIVEiP80511
PaxDbiP80511
PeptideAtlasiP80511
PRIDEiP80511
ProteomicsDBi57687
TopDownProteomicsiP80511

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1076, 328 antibodies

The CPTC Antibody Portal

More...CPTCi		P80511, 1 antibody

The DNASU plasmid repository

More...DNASUi		6283

Genome annotation databases

EnsembliENST00000368737; ENSP00000357726; ENSG00000163221
GeneIDi6283
KEGGihsa:6283
UCSCiuc001fbr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6283
DisGeNETi6283

GeneCards: human genes, protein and diseases

More...GeneCardsi		S100A12
HGNCiHGNC:10489, S100A12
HPAiENSG00000163221, Group enriched (blood, bone marrow, lymphoid tissue)
MIMi603112, gene
neXtProtiNX_P80511
OpenTargetsiENSG00000163221
PharmGKBiPA34901
VEuPathDBiHostDB:ENSG00000163221.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SA01, Eukaryota
GeneTreeiENSGT00940000162189
HOGENOMiCLU_138624_6_2_1
InParanoidiP80511
OMAiHMEGIIN
OrthoDBi1521098at2759
PhylomeDBiP80511
TreeFamiTF332727

Enzyme and pathway databases

PathwayCommonsiP80511
ReactomeiR-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-6798695, Neutrophil degranulation
R-HSA-879415, Advanced glycosylation endproduct receptor signaling
R-HSA-933542, TRAF6 mediated NF-kB activation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6283, 3 hits in 878 CRISPR screens
EvolutionaryTraceiP80511

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		S100A12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6283
PharosiP80511, Tbio

Protein Ontology

More...PROi		PR:P80511
RNActiP80511, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163221, Expressed in bone marrow and 165 other tissues
GenevisibleiP80511, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR001751, S100/CaBP-9k_CS
IPR013787, S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023, S_100, 1 hit
SMARTiView protein in SMART
SM01394, S_100, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS00303, S100_CABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS10AC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P80511
Secondary accession number(s): P83219, Q5SY66, Q7M4R1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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