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Protein

Alcohol dehydrogenase 4

Gene

ADH4

Organism
Struthio camelus (Common ostrich)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

SABIO-RKiP80468

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class II
Gene namesi
Name:ADH4
OrganismiStruthio camelus (Common ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606861 – 379Alcohol dehydrogenase 4Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylthreonine2 Publications1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP80468

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP80468
SMRiP80468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P80468-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TTEGKVIKCK AAIAWEAGKP LSVEEIEVSP PKDHEVRVKI VATGVCRTDE
60 70 80 90 100
HAINPSFKEG VFPVILGHEG AGIVESIGQG VSKFKPGDKV IPLYMPQCGH
110 120 130 140 150
CKFCLNPKTN LCEKISKIKT PISDQEVMSD GTSRFTCKGK PIYHFMGTST
160 170 180 190 200
FSEYTVVSES SLAKIDAAAP LDKVCLIGCG FSTGYGAAIN TAQVEPGSTC
210 220 230 240 250
AVFGLGGVGL SAVMGCKAAG ASKIFGIDIN KDKFPLAKKL GATDCLNPQD
260 270 280 290 300
IRKPVQEIIA EMTNGGVDFA IECIGNPDVM KAAFESTTVG WGTCVIVGVA
310 320 330 340 350
VGEQSIPFSP MQLIMGRKIK ATFFGGWKSV KSVPKLVSDY MAKKFDLDAL
360 370
VSHTLPLDKI NDAFDLMNAG KSNRTILVF
Length:379
Mass (Da):40,310
Last modified:February 1, 1996 - v1
Checksum:i9BD05DFC286561BF
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP80468
SMRiP80468
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP80468

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195

Enzyme and pathway databases

SABIO-RKiP80468

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR028632 Zinc_ADH_II
PANTHERiPTHR43880:SF14 PTHR43880:SF14, 1 hit
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH4_STRCA
AccessioniPrimary (citable) accession number: P80468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 20, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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