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Protein

Leech-derived tryptase inhibitor C

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei8 – 9Reactive bond (tryptase)2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.021

Names & Taxonomyi

Protein namesi
Recommended name:
Leech-derived tryptase inhibitor C
Short name:
LDTI-C
Cleaved into the following 2 chains:
OrganismiHirudo medicinalis (Medicinal leech)
Taxonomic identifieri6421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudineaHirudinidaHirudiniformesHirudinidaeHirudo

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000458821 – 46Leech-derived tryptase inhibitor CAdd BLAST46
ChainiPRO_00000458831 – 43Leech-derived tryptase inhibitor BAdd BLAST43
ChainiPRO_00000458841 – 42Leech-derived tryptase inhibitor AAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 29
Disulfide bondi6 ↔ 25
Disulfide bondi14 ↔ 40

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-6084N
IntActiP80424, 1 interactor
MINTiP80424

Structurei

Secondary structure

146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80424
SMRiP80424
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80424

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 42Kazal-likePROSITE-ProRule annotationAdd BLAST42

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80424-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
KKVCACPKIL KPVCGSDGRT YANSCIARCN GVSIKSEGSC PTGILN
Length:46
Mass (Da):4,744
Last modified:February 1, 1995 - v1
Checksum:i9FC4383FF5C009A1
GO

Sequence databases

PIRiS50015

Cross-referencesi

Sequence databases

PIRiS50015

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AN1X-ray2.03I1-46[»]
1LDTX-ray1.90L1-46[»]
2KMONMR-A1-44[»]
2KMPNMR-A1-44[»]
2KMQNMR-A1-44[»]
2KMRNMR-A1-44[»]
ProteinModelPortaliP80424
SMRiP80424
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6084N
IntActiP80424, 1 interactor
MINTiP80424

Protein family/group databases

MEROPSiI01.021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80424

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDTI_HIRME
AccessioniPrimary (citable) accession number: P80424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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