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Protein

Metallothionein-1

Gene
N/A
Organism
Tetrahymena pigmentosa
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions. Binds 12 cadmium ions per molecule.

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Cleaved into the following chain:
Metallothionein-2
Short name:
MT-2
OrganismiTetrahymena pigmentosa
Taxonomic identifieri5907 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000186671 – 21 Publication2
ChainiPRO_00000186683 – 107Metallothionein-1Add BLAST105
ChainiPRO_00000186694 – 107Metallothionein-2Add BLAST104

Expressioni

Inductioni

By cadmium.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVNNNCCC GENAKPCCTD PNSGCCCVSE TNNCCKSDKK ECCTGTGEGC
60 70 80 90 100
KCTGCKCCQP AKSGCCCGDK AKACCTDPNS GCCCSSKTNK CCDSTNKTEC

KTCECCK
Length:107
Mass (Da):11,096
Last modified:May 9, 2003 - v2
Checksum:i41C85CCB1A8E465C
GO

Mass spectrometryi

Molecular mass is 10850±1 Da from positions 3 - 107. Determined by ESI. 1 Publication
Molecular mass is 10722±1 Da from positions 4 - 107. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509328 Genomic DNA Translation: AAM34287.1
PIRiS50911

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509328 Genomic DNA Translation: AAM34287.1
PIRiS50911

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012484 Metalthion_7
PfamiView protein in Pfam
PF07846 Metallothio_Cad, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_TETPI
AccessioniPrimary (citable) accession number: P80394
Secondary accession number(s): Q8MZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 9, 2003
Last modified: October 1, 2014
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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Main funding by: National Institutes of Health

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