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Protein

T-complex protein 1 subunit gamma

Gene

Cct3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit gamma
Short name:
TCP-1-gamma
Alternative name(s):
CCT-gamma
Matricin
mTRiC-P5
Gene namesi
Name:Cct3
Synonyms:Cctg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104708 Cct3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283221 – 545T-complex protein 1 subunit gammaAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei170PhosphoserineCombined sources1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei247PhosphotyrosineBy similarity1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei252PhosphoserineCombined sources1
Disulfide bondi366 ↔ 372
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei430PhosphothreonineBy similarity1
Modified residuei459PhosphothreonineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP80318
PaxDbiP80318
PeptideAtlasiP80318
PRIDEiP80318

2D gel databases

REPRODUCTION-2DPAGEiIPI00116283
P80318

PTM databases

iPTMnetiP80318
PhosphoSitePlusiP80318
SwissPalmiP80318

Expressioni

Gene expression databases

BgeeiENSMUSG00000001416 Expressed in 302 organ(s), highest expression level in cochlea
CleanExiMM_CCT3
ExpressionAtlasiP80318 baseline and differential
GenevisibleiP80318 MM

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (PubMed:23872636).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045913EBI-772361,EBI-10634977From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198565, 50 interactors
CORUMiP80318
DIPiDIP-32344N
IntActiP80318, 60 interactors
MINTiP80318
STRINGi10090.ENSMUSP00000001452

Structurei

Secondary structure

1545
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80318
SMRiP80318
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80318

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0364 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00570000079224
HOGENOMiHOG000226732
HOVERGENiHBG104982
InParanoidiP80318
KOiK09495
OMAiHFLLKAG
OrthoDBiEOG091G0677
PhylomeDBiP80318
TreeFamiTF105649

Family and domain databases

CDDicd03337 TCP1_gamma, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012719 Chap_CCT_gamma
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02344 chap_CCT_gamma, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P80318-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGHRPVLVL SQNTKRESGR KVQSGNINAA KTIADIIRTC LGPKSMMKML
60 70 80 90 100
LDPMGGIVMT NDGNAILREI QVQHPAAKSM IEISRTQDEE VGDGTTSVII
110 120 130 140 150
LAGEMLSVAE HFLEQQMHPT VVISAYRMAL DDMISTLKKI STPVDVNNRE
160 170 180 190 200
MMLSIINSSI TTKVISRWSS LACNIALDAV KTVQFEENGR KEIDIKKYAR
210 220 230 240 250
VEKIPGGIIE DSCVLRGVMI NKDVTHPRMR RYIKNPRIVL LDSSLEYKKG
260 270 280 290 300
ESQTDIEITR EEDFTRILQM EEEYIHQLCE DIIQLKPDVV ITEKGISDLA
310 320 330 340 350
QHYLMRANVT AIRRVRKTDN NRIARACGAR IVSRPEELRE DDVGTGAGLL
360 370 380 390 400
EIKKIGDEYF TFITDCKDPK ACTILLRGAS KEILSEVERN LQDAMQVCRN
410 420 430 440 450
VLLDPQLVPG GGASEMAVAH ALTEKSKAMT GVEQWPYRAV AQALEVIPRT
460 470 480 490 500
LIQNCGASTI RLLTSLRAKH TQESCETWGV NGETGTLVDM KELGIWEPLA
510 520 530 540
VKLQTYKTAV ETAVLLLRID DIVSGHKKKG DDQNRQTGAP DAGQE
Length:545
Mass (Da):60,630
Last modified:June 1, 1994 - v1
Checksum:i492F9743C607FA1D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q133E9Q133_MOUSE
T-complex protein 1 subunit gamma
Cct3
507Annotation score:
Q3U0I3Q3U0I3_MOUSE
T-complex protein 1 subunit gamma
Cct3
521Annotation score:
F6Q609F6Q609_MOUSE
T-complex protein 1 subunit gamma
Cct3
306Annotation score:
F6ZVG8F6ZVG8_MOUSE
T-complex protein 1 subunit gamma
Cct3
85Annotation score:

Sequence cautioni

The sequence AAA19749 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124S → G in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti150E → D in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti154S → N in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti276H → Q in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti365D → E in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti474S → N in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti534N → S in AAA19749 (PubMed:8110840).Curated1
Sequence conflicti537 – 538TG → SS in AAA19749 (PubMed:8110840).Curated2
Sequence conflicti542A → G in AAA19749 (PubMed:8110840).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31556 mRNA Translation: CAA83431.1
L20509 mRNA Translation: AAA19749.1 Different initiation.
CCDSiCCDS17468.1
PIRiS42723
S43062
RefSeqiNP_033966.1, NM_009836.1
UniGeneiMm.256034

Genome annotation databases

EnsembliENSMUST00000001452; ENSMUSP00000001452; ENSMUSG00000001416
GeneIDi12462
KEGGimmu:12462
UCSCiuc008puo.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31556 mRNA Translation: CAA83431.1
L20509 mRNA Translation: AAA19749.1 Different initiation.
CCDSiCCDS17468.1
PIRiS42723
S43062
RefSeqiNP_033966.1, NM_009836.1
UniGeneiMm.256034

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GMLX-ray2.20A/B/C/D210-380[»]
1GN1X-ray2.80A/B/C/D/E/F/G/H210-380[»]
ProteinModelPortaliP80318
SMRiP80318
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198565, 50 interactors
CORUMiP80318
DIPiDIP-32344N
IntActiP80318, 60 interactors
MINTiP80318
STRINGi10090.ENSMUSP00000001452

PTM databases

iPTMnetiP80318
PhosphoSitePlusiP80318
SwissPalmiP80318

2D gel databases

REPRODUCTION-2DPAGEiIPI00116283
P80318

Proteomic databases

EPDiP80318
PaxDbiP80318
PeptideAtlasiP80318
PRIDEiP80318

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001452; ENSMUSP00000001452; ENSMUSG00000001416
GeneIDi12462
KEGGimmu:12462
UCSCiuc008puo.3 mouse

Organism-specific databases

CTDi7203
MGIiMGI:104708 Cct3

Phylogenomic databases

eggNOGiKOG0364 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00570000079224
HOGENOMiHOG000226732
HOVERGENiHBG104982
InParanoidiP80318
KOiK09495
OMAiHFLLKAG
OrthoDBiEOG091G0677
PhylomeDBiP80318
TreeFamiTF105649

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSiCct3 mouse
EvolutionaryTraceiP80318
PROiPR:P80318
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001416 Expressed in 302 organ(s), highest expression level in cochlea
CleanExiMM_CCT3
ExpressionAtlasiP80318 baseline and differential
GenevisibleiP80318 MM

Family and domain databases

CDDicd03337 TCP1_gamma, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012719 Chap_CCT_gamma
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02344 chap_CCT_gamma, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPG_MOUSE
AccessioniPrimary (citable) accession number: P80318
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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