Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-complex protein 1 subunit delta

Gene

Cct4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
A45
CCT-delta
Gene namesi
Name:Cct4
Synonyms:Cctd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104689 Cct4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283331 – 539T-complex protein 1 subunit deltaAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei184PhosphoserineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei288N6-acetyllysineBy similarity1
Modified residuei302N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysineCombined sources1
Modified residuei326N6-acetyllysineBy similarity1
Modified residuei444PhosphoserineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP80315
PaxDbiP80315
PeptideAtlasiP80315
PRIDEiP80315

2D gel databases

REPRODUCTION-2DPAGEiP80315

PTM databases

iPTMnetiP80315
PhosphoSitePlusiP80315
SwissPalmiP80315

Expressioni

Gene expression databases

BgeeiENSMUSG00000007739 Expressed in 288 organ(s), highest expression level in indifferent gonad
CleanExiMM_CCT4
ExpressionAtlasiP80315 baseline and differential
GenevisibleiP80315 MM

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (PubMed:23872636).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198567, 56 interactors
CORUMiP80315
IntActiP80315, 54 interactors
MINTiP80315
STRINGi10090.ENSMUSP00000133523

Structurei

3D structure databases

ProteinModelPortaliP80315
SMRiP80315
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
HOVERGENiHBG106507
InParanoidiP80315
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiP80315
TreeFamiTF106332

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P80315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPENVASRSG APTAGPGSRG KSAYQDRDKP AQIRFSNISA AKAVADAIRT
60 70 80 90 100
SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI
110 120 130 140 150
EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGLEILTD
160 170 180 190 200
MSRPVQLSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA
210 220 230 240 250
TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVANSGITR VEKAKIGLIQ
260 270 280 290 300
FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
310 320 330 340 350
QKSILRDALS DLALHFLNKM KIMVVKDVER EDIEFICKTI GTKPVAHIDQ
360 370 380 390 400
FTADMLGSAE LAEEVSLNGS GKLFKITGCT SPGKTVTIVV RGSNKLVIEE
410 420 430 440 450
AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC
460 470 480 490 500
VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT TGINVRKGGI
510 520 530
SNILEEMVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR
Length:539
Mass (Da):58,066
Last modified:January 23, 2007 - v3
Checksum:iB3EBD470D1C7FABC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E839G5E839_MOUSE
T-complex protein 1 subunit delta
Cct4
509Annotation score:
G3UYW5G3UYW5_MOUSE
T-complex protein 1 subunit delta
Cct4
120Annotation score:
G3UXF3G3UXF3_MOUSE
T-complex protein 1 subunit delta
Cct4
47Annotation score:
G3UXG2G3UXG2_MOUSE
T-complex protein 1 subunit delta
Cct4
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405I → V in AAA37418 (PubMed:7919332).Curated1
Sequence conflicti443L → P in AAA37418 (PubMed:7919332).Curated1
Sequence conflicti453A → R in AAA37418 (PubMed:7919332).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25913 mRNA Translation: AAA37418.1
Z31554 mRNA Translation: CAA83429.1
AB022157 Genomic DNA Translation: BAA81875.1
BC054773 mRNA Translation: AAH54773.1
CCDSiCCDS24474.1
PIRiS43060
RefSeqiNP_033967.1, NM_009837.1
UniGeneiMm.296985
Mm.394074
Mm.441628

Genome annotation databases

EnsembliENSMUST00000173867; ENSMUSP00000133523; ENSMUSG00000007739
GeneIDi12464
KEGGimmu:12464
UCSCiuc007ien.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25913 mRNA Translation: AAA37418.1
Z31554 mRNA Translation: CAA83429.1
AB022157 Genomic DNA Translation: BAA81875.1
BC054773 mRNA Translation: AAH54773.1
CCDSiCCDS24474.1
PIRiS43060
RefSeqiNP_033967.1, NM_009837.1
UniGeneiMm.296985
Mm.394074
Mm.441628

3D structure databases

ProteinModelPortaliP80315
SMRiP80315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198567, 56 interactors
CORUMiP80315
IntActiP80315, 54 interactors
MINTiP80315
STRINGi10090.ENSMUSP00000133523

PTM databases

iPTMnetiP80315
PhosphoSitePlusiP80315
SwissPalmiP80315

2D gel databases

REPRODUCTION-2DPAGEiP80315

Proteomic databases

EPDiP80315
PaxDbiP80315
PeptideAtlasiP80315
PRIDEiP80315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173867; ENSMUSP00000133523; ENSMUSG00000007739
GeneIDi12464
KEGGimmu:12464
UCSCiuc007ien.1 mouse

Organism-specific databases

CTDi10575
MGIiMGI:104689 Cct4

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
HOVERGENiHBG106507
InParanoidiP80315
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiP80315
TreeFamiTF106332

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:P80315
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007739 Expressed in 288 organ(s), highest expression level in indifferent gonad
CleanExiMM_CCT4
ExpressionAtlasiP80315 baseline and differential
GenevisibleiP80315 MM

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPD_MOUSE
AccessioniPrimary (citable) accession number: P80315
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again