Cct4

Functionⁱ

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein binding involved in protein folding Source: GO_Central
unfolded protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

'de novo' protein folding Source: GO_Central
binding of sperm to zona pellucida
Source: MGI
Inferred from direct assayⁱ
- 21880732
chaperone-mediated protein folding Source: GO_Central
positive regulation of establishment of protein localization to telomere Source: MGI
positive regulation of telomerase activity Source: MGI
positive regulation of telomerase RNA localization to Cajal body Source: MGI
positive regulation of telomere maintenance via telomerase Source: MGI
protein stabilization Source: MGI
scaRNA localization to Cajal body Source: MGI
toxin transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 23716698

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-complex protein 1 subunit delta Short name: TCP-1-delta Alternative name(s): A45 CCT-delta
Gene namesⁱ	Name:Cct4 Synonyms:Cctd
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:104689 Cct4

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000128333	1 – 539	T-complex protein 1 subunit deltaAdd BLAST		539

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	21	N6-acetyllysineCombined sources	1
Modified residueⁱ	36	PhosphoserineBy similarity	1
Modified residueⁱ	184	PhosphoserineBy similarity	1
Modified residueⁱ	202	PhosphoserineBy similarity	1
Modified residueⁱ	288	N6-acetyllysineBy similarity	1
Modified residueⁱ	302	N6-acetyllysineBy similarity	1
Modified residueⁱ	319	N6-acetyllysineCombined sources	1
Modified residueⁱ	326	N6-acetyllysineBy similarity	1
Modified residueⁱ	444	PhosphoserineBy similarity	1

Post-translational modificationⁱ

The N-terminus is blocked.

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P80315
PaxDbⁱ	P80315
PeptideAtlas More...PeptideAtlasⁱ	P80315
PRIDEⁱ	P80315

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	P80315

REPRODUCTION-2DPAGEⁱ

P80315

PTM databases

iPTMnetⁱ	P80315
PhosphoSitePlusⁱ	P80315
SwissPalmⁱ	P80315

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007739
CleanExⁱ	MM_CCT4
ExpressionAtlasⁱ	P80315 baseline and differential
Genevisibleⁱ	P80315 MM

Interactionⁱ

Subunit structureⁱ

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity). Interacts with DNAAF4.By similarity1 Publication

GO - Molecular functionⁱ

protein binding involved in protein folding Source: GO_Central
unfolded protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198567, 55 interactors
CORUMⁱ	P80315
IntActⁱ	P80315, 53 interactors
Molecular INTeraction database More...MINTⁱ	P80315
STRINGⁱ	10090.ENSMUSP00000133523

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P80315
SMRⁱ	P80315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0358 Eukaryota COG0459 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074956
HOGENOMⁱ	HOG000226735
HOVERGENⁱ	HBG106507
InParanoidⁱ	P80315
KEGG Orthology (KO) More...KOⁱ	K09496
OMAⁱ	QFCLSPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05G4
PhylomeDBⁱ	P80315
TreeFamⁱ	TF106332

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03338 TCP1_delta, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012717 Chap_CCT_delta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits
TIGRFAMsⁱ	TIGR02342 chap_CCT_delta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P80315-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPENVASRSG APTAGPGSRG KSAYQDRDKP AQIRFSNISA AKAVADAIRT 
        60         70         80         90        100
SLGPKGMDKM IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI 
       110        120        130        140        150
EAGDGTTSVV IIAGSLLDSC TKLLQKGIHP TIISESFQKA LEKGLEILTD 
       160        170        180        190        200
MSRPVQLSDR ETLLNSATTS LNSKVVSQYS SLLSPMSVNA VMKVIDPATA 
       210        220        230        240        250
TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVANSGITR VEKAKIGLIQ 
       260        270        280        290        300
FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI 
       310        320        330        340        350
QKSILRDALS DLALHFLNKM KIMVVKDVER EDIEFICKTI GTKPVAHIDQ 
       360        370        380        390        400
FTADMLGSAE LAEEVSLNGS GKLFKITGCT SPGKTVTIVV RGSNKLVIEE 
       410        420        430        440        450
AERSIHDALC VIRCLVKKRA LIAGGGAPEI ELALRLTEYS RTLSGMESYC 
       460        470        480        490        500
VRAFADAMEV IPSTLAENAG LNPISTVTEL RNRHAQGEKT TGINVRKGGI 
       510        520        530 
SNILEEMVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR

Length:539

Mass (Da):58,066

Last modified:January 23, 2007 - v3

Checksum:ⁱB3EBD470D1C7FABC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	405	I → V in AAA37418 (PubMed:7919332).Curated	1
Sequence conflictⁱ	443	L → P in AAA37418 (PubMed:7919332).Curated	1
Sequence conflictⁱ	453	A → R in AAA37418 (PubMed:7919332).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L25913 mRNA Translation: AAA37418.1 Z31554 mRNA Translation: CAA83429.1 AB022157 Genomic DNA Translation: BAA81875.1 BC054773 mRNA Translation: AAH54773.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24474.1
PIRⁱ	S43060
NCBI Reference Sequences More...RefSeqⁱ	NP_033967.1, NM_009837.1
UniGeneⁱ	Mm.296985 Mm.394074 Mm.441628

Genome annotation databases

Ensemblⁱ	ENSMUST00000173867; ENSMUSP00000133523; ENSMUSG00000007739
GeneIDⁱ	12464
KEGGⁱ	mmu:12464
UCSC genome browser More...UCSCⁱ	uc007ien.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P80315	T-complex protein 1 subunit delta		Daphnia magna		539
T-complex protein 1 subunit delta		MOUSE		539

Protein	Similar proteins		Species	Score	Length
P80315	T-complex protein 1 subunit delta		HUMAN		539
T-complex protein 1 subunit delta		PANTR		539
T-complex protein 1 subunit delta		PONAB		539
T-complex protein 1 subunit delta		PANPA		539
T-complex protein 1 subunit delta		NOMLE		539
+158

Protein	Similar proteins		Species	Score	Length
P80315	T-complex protein 1 subunit delta		HUMAN		539
T-complex protein 1 subunit delta		PANTR		539
T-complex protein 1 subunit delta		PONAB		539
T-complex protein 1 subunit delta		PANPA		539
T-complex protein 1 subunit delta		NOMLE		539
+674

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L25913 mRNA Translation: AAA37418.1 Z31554 mRNA Translation: CAA83429.1 AB022157 Genomic DNA Translation: BAA81875.1 BC054773 mRNA Translation: AAH54773.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24474.1
PIRⁱ	S43060
NCBI Reference Sequences More...RefSeqⁱ	NP_033967.1, NM_009837.1
UniGeneⁱ	Mm.296985 Mm.394074 Mm.441628

3D structure databases

ProteinModelPortalⁱ	P80315
SMRⁱ	P80315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198567, 55 interactors
CORUMⁱ	P80315
IntActⁱ	P80315, 53 interactors
Molecular INTeraction database More...MINTⁱ	P80315
STRINGⁱ	10090.ENSMUSP00000133523

PTM databases

iPTMnetⁱ	P80315
PhosphoSitePlusⁱ	P80315
SwissPalmⁱ	P80315

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	P80315

REPRODUCTION-2DPAGEⁱ

P80315

Proteomic databases

EPDⁱ	P80315
PaxDbⁱ	P80315
PeptideAtlas More...PeptideAtlasⁱ	P80315
PRIDEⁱ	P80315

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000173867; ENSMUSP00000133523; ENSMUSG00000007739
GeneIDⁱ	12464
KEGGⁱ	mmu:12464
UCSC genome browser More...UCSCⁱ	uc007ien.1 mouse

Organism-specific databases

CTDⁱ	10575
MGIⁱ	MGI:104689 Cct4

Phylogenomic databases

eggNOGⁱ	KOG0358 Eukaryota COG0459 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074956
HOGENOMⁱ	HOG000226735
HOVERGENⁱ	HBG106507
InParanoidⁱ	P80315
KEGG Orthology (KO) More...KOⁱ	K09496
OMAⁱ	QFCLSPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05G4
PhylomeDBⁱ	P80315
TreeFamⁱ	TF106332

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P80315
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007739
CleanExⁱ	MM_CCT4
ExpressionAtlasⁱ	P80315 baseline and differential
Genevisibleⁱ	P80315 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03338 TCP1_delta, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012717 Chap_CCT_delta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits
TIGRFAMsⁱ	TIGR02342 chap_CCT_delta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCPD_MOUSE
Accessionⁱ	P80315Primary (citable) accession number: P80315
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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Annotation systems

Supporting data

UniProtKB - P80315 (TCPD_MOUSE)

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T-complex protein 1 subunit delta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ