UniProtKB - P80313 (TCPH_MOUSE)
Protein
T-complex protein 1 subunit eta
Gene
Cct7
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin.By similarity
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: MGI
- protein folding chaperone Source: MGI
- unfolded protein binding Source: GO_Central
GO - Biological processi
- binding of sperm to zona pellucida Source: MGI
- positive regulation of establishment of protein localization to telomere Source: MGI
- positive regulation of telomere maintenance via telomerase Source: MGI
- protein folding Source: MGI
- protein stabilization Source: MGI
- toxin transport Source: MGI
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-390471, Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit etaShort name: TCP-1-eta Alternative name(s): CCT-eta |
Gene namesi | Name:Cct7 Synonyms:Ccth |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107184, Cct7 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- microtubule Source: MGI
Cytosol
- chaperonin-containing T-complex Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Other locations
- cell body Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128366 | 1 – 544 | T-complex protein 1 subunit etaAdd BLAST | 544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 67 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 250 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 320 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 430 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 536 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
The N-terminus is blocked.
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Ubl conjugationProteomic databases
EPDi | P80313 |
jPOSTi | P80313 |
PaxDbi | P80313 |
PeptideAtlasi | P80313 |
PRIDEi | P80313 |
ProteomicsDBi | 263025 |
2D gel databases
REPRODUCTION-2DPAGEi | P80313 |
PTM databases
iPTMneti | P80313 |
PhosphoSitePlusi | P80313 |
SwissPalmi | P80313 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030007, Expressed in floor plate of midbrain and 311 other tissues |
ExpressionAtlasi | P80313, baseline and differential |
Genevisiblei | P80313, MM |
Interactioni
Subunit structurei
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198571, 50 interactors |
CORUMi | P80313 |
IntActi | P80313, 30 interactors |
MINTi | P80313 |
STRINGi | 10090.ENSMUSP00000032078 |
Miscellaneous databases
RNActi | P80313, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0361, Eukaryota |
GeneTreei | ENSGT00550000074832 |
HOGENOMi | CLU_008891_7_1_1 |
InParanoidi | P80313 |
OMAi | QGCPNAK |
OrthoDBi | 335406at2759 |
PhylomeDBi | P80313 |
TreeFami | TF105641 |
Family and domain databases
CDDi | cd03340, TCP1_eta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012720, Chap_CCT_eta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF22, PTHR11353:SF22, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02345, chap_CCT_eta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P80313-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKQDKVE
160 170 180 190 200
QRKMLEKCAM TALSSKLISQ QKVFFAKMVV DAVMMLDELL QLKMIGIKKV
210 220 230 240 250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK KYKNPKIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHQSGAKVIL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALVPD VLGHCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TIILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGMWYGVDIN NENIADNFQA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDPP APSAGRGRGQ ARFH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SV00 | A0A0N4SV00_MOUSE | T-complex protein 1 subunit eta | Cct7 | 502 | Annotation score: | ||
A0A0N4SUI8 | A0A0N4SUI8_MOUSE | T-complex protein 1 subunit eta | Cct7 | 79 | Annotation score: | ||
A0A0N4SV22 | A0A0N4SV22_MOUSE | T-complex protein 1 subunit eta | Cct7 | 83 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z31399 mRNA Translation: CAA83274.1 AB022160 Genomic DNA Translation: BAA81878.1 BC008255 mRNA Translation: AAH08255.1 |
CCDSi | CCDS20295.1 |
PIRi | S43058 |
RefSeqi | NP_031664.3, NM_007638.4 |
Genome annotation databases
Ensembli | ENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007 |
GeneIDi | 12468 |
KEGGi | mmu:12468 |
UCSCi | uc009cpv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z31399 mRNA Translation: CAA83274.1 AB022160 Genomic DNA Translation: BAA81878.1 BC008255 mRNA Translation: AAH08255.1 |
CCDSi | CCDS20295.1 |
PIRi | S43058 |
RefSeqi | NP_031664.3, NM_007638.4 |
3D structure databases
SMRi | P80313 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198571, 50 interactors |
CORUMi | P80313 |
IntActi | P80313, 30 interactors |
MINTi | P80313 |
STRINGi | 10090.ENSMUSP00000032078 |
PTM databases
iPTMneti | P80313 |
PhosphoSitePlusi | P80313 |
SwissPalmi | P80313 |
2D gel databases
REPRODUCTION-2DPAGEi | P80313 |
Proteomic databases
EPDi | P80313 |
jPOSTi | P80313 |
PaxDbi | P80313 |
PeptideAtlasi | P80313 |
PRIDEi | P80313 |
ProteomicsDBi | 263025 |
Protocols and materials databases
Antibodypediai | 1382, 272 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007 |
GeneIDi | 12468 |
KEGGi | mmu:12468 |
UCSCi | uc009cpv.2, mouse |
Organism-specific databases
CTDi | 10574 |
MGIi | MGI:107184, Cct7 |
Phylogenomic databases
eggNOGi | KOG0361, Eukaryota |
GeneTreei | ENSGT00550000074832 |
HOGENOMi | CLU_008891_7_1_1 |
InParanoidi | P80313 |
OMAi | QGCPNAK |
OrthoDBi | 335406at2759 |
PhylomeDBi | P80313 |
TreeFami | TF105641 |
Enzyme and pathway databases
Reactomei | R-MMU-390471, Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Miscellaneous databases
BioGRID-ORCSi | 12468, 25 hits in 48 CRISPR screens |
ChiTaRSi | Cct7, mouse |
PROi | PR:P80313 |
RNActi | P80313, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030007, Expressed in floor plate of midbrain and 311 other tissues |
ExpressionAtlasi | P80313, baseline and differential |
Genevisiblei | P80313, MM |
Family and domain databases
CDDi | cd03340, TCP1_eta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012720, Chap_CCT_eta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
PANTHERi | PTHR11353:SF22, PTHR11353:SF22, 1 hit |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02345, chap_CCT_eta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPH_MOUSE | |
Accessioni | P80313Primary (citable) accession number: P80313 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families