UniProtKB - P80313 (TCPH_MOUSE)

BLAST

>sp|P80313|TCPH_MOUSE T-complex protein 1 subunit eta OS=Mus musculus OX=10090 GN=Cct7 PE=1 SV=1
MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISN
DGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQI
IIRAFRTATQLAVNKIKEIAVTVKKQDKVEQRKMLEKCAMTALSSKLISQQKVFFAKMVV
DAVMMLDELLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALL
NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVAT
QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALVPDVLGHCQVFEETQIGGERYNF
FTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL
RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDIN
NENIADNFQAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDPPAPSAGRGRGQ
ARFH

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History
Entry version 165 (07 Nov 2018)
Sequence version 1 (01 Jun 1994)
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Protein

T-complex protein 1 subunit eta

Gene

Cct7

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
identical protein binding
Source: MGI
Inferred from physical interactionⁱ
- 11591653
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

binding of sperm to zona pellucida
Source: MGI
Inferred from direct assayⁱ
- 21880732
positive regulation of establishment of protein localization to telomere Source: MGI
positive regulation of telomere maintenance via telomerase Source: MGI
protein folding Source: InterPro
protein stabilization Source: MGI
toxin transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 23716698

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-complex protein 1 subunit eta Short name: TCP-1-eta Alternative name(s): CCT-eta
Gene namesⁱ	Name:Cct7 Synonyms:Ccth
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:107184 Cct7

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000128366	1 – 544	T-complex protein 1 subunit etaAdd BLAST		544

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	67	N6-acetyllysineBy similarity	1
Modified residueⁱ	250	N6-acetyllysineCombined sources	1
Modified residueⁱ	320	N6-acetyllysineBy similarity	1
Cross-linkⁱ	430	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	536	Omega-N-methylarginineCombined sources	1

Post-translational modificationⁱ

The N-terminus is blocked.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDⁱ	P80313
PaxDbⁱ	P80313
PeptideAtlas More...PeptideAtlasⁱ	P80313
PRIDEⁱ	P80313

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	P80313

REPRODUCTION-2DPAGEⁱ

P80313

PTM databases

iPTMnetⁱ	P80313
PhosphoSitePlusⁱ	P80313
SwissPalmⁱ	P80313

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030007 Expressed in 295 organ(s), highest expression level in floor plate of midbrain
CleanExⁱ	MM_CCT7
ExpressionAtlasⁱ	P80313 baseline and differential
Genevisibleⁱ	P80313 MM

Interactionⁱ

Subunit structureⁱ

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.By similarity

GO - Molecular functionⁱ

identical protein binding
Source: MGI
Inferred from physical interactionⁱ
- 11591653
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198571, 29 interactors
CORUMⁱ	P80313
IntActⁱ	P80313, 29 interactors
Molecular INTeraction database More...MINTⁱ	P80313
STRINGⁱ	10090.ENSMUSP00000032078

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P80313
SMRⁱ	P80313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0360 Eukaryota COG0459 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074832
HOGENOMⁱ	HOG000226730
HOVERGENⁱ	HBG001052
InParanoidⁱ	P80313
KEGG Orthology (KO) More...KOⁱ	K09499
OMAⁱ	QGCPNAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05UO
PhylomeDBⁱ	P80313
TreeFamⁱ	TF105641

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03340 TCP1_eta, 1 hit
Gene3Dⁱ	1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012720 Chap_CCT_eta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
PANTHERⁱ	PTHR11353:SF22 PTHR11353:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02345 chap_CCT_eta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P80313-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV 
        60         70         80         90        100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL 
       110        120        130        140        150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKQDKVE 
       160        170        180        190        200
QRKMLEKCAM TALSSKLISQ QKVFFAKMVV DAVMMLDELL QLKMIGIKKV 
       210        220        230        240        250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK KYKNPKIALL NVELELKAEK 
       260        270        280        290        300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHQSGAKVIL SKLPIGDVAT 
       310        320        330        340        350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALVPD VLGHCQVFEE 
       360        370        380        390        400
TQIGGERYNF FTGCPKAKTC TIILRGGAEQ FMEETERSLH DAIMIVRRAI 
       410        420        430        440        450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC 
       460        470        480        490        500
DNAGFDATNI LNKLRARHAQ GGMWYGVDIN NENIADNFQA FVWEPAMVRI 
       510        520        530        540 
NALTAASEAA CLIVSVDETI KNPRSTVDPP APSAGRGRGQ ARFH

Length:544

Mass (Da):59,652

Last modified:June 1, 1994 - v1

Checksum:ⁱ0BD7AD35456EE677

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0N4SV00	A0A0N4SV00_MOUSE	T-complex protein 1 subunit eta T-complex protein 1 subunit eta, TCP-1-eta (CCT-eta)	Cct7	502	Annotation score:
A0A0N4SV22	A0A0N4SV22_MOUSE	T-complex protein 1 subunit eta T-complex protein 1 subunit eta, TCP-1-eta (CCT-eta)	Cct7	83	Annotation score:
A0A0N4SUI8	A0A0N4SUI8_MOUSE	T-complex protein 1 subunit eta T-complex protein 1 subunit eta, TCP-1-eta (CCT-eta)	Cct7	79	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31399 mRNA Translation: CAA83274.1 AB022160 Genomic DNA Translation: BAA81878.1 BC008255 mRNA Translation: AAH08255.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20295.1
PIRⁱ	S43058
NCBI Reference Sequences More...RefSeqⁱ	NP_031664.3, NM_007638.4
UniGeneⁱ	Mm.289900 Mm.456037

Genome annotation databases

Ensemblⁱ	ENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007
GeneIDⁱ	12468
KEGGⁱ	mmu:12468
UCSC genome browser More...UCSCⁱ	uc009cpv.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P80313	T-complex protein 1 subunit eta		MOUSE		544	UniRef100_P80313
T-complex protein 1 subunit eta (Fragment)		Daphnia magna		200
T-complex protein 1 subunit eta (Fragment)		MOUSE		481

Protein	Similar proteins		Species	Score	Length	Source
P80313	T-complex protein 1 subunit eta		MOUSE		544	UniRef90_P80313
T-complex protein 1 subunit eta (Fragment)		Daphnia magna		200
T-complex protein 1 subunit eta		MACNE		578
T-complex protein 1 subunit eta		PTEAL		572
T-complex protein 1 subunit eta		NEOLE		556
+77

Protein	Similar proteins		Species	Score	Length	Source
P80313	T-complex protein 1 subunit eta		PLAF7		539	UniRef50_P80313
T-complex protein 1 subunit eta		ARATH		557
T-complex protein 1 subunit eta		MOUSE		544
T-complex protein 1 subunit eta (Fragment)		Daphnia magna		200
T-complex protein 1 subunit eta		MACNE		578
+662

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31399 mRNA Translation: CAA83274.1 AB022160 Genomic DNA Translation: BAA81878.1 BC008255 mRNA Translation: AAH08255.1
CCDSⁱ	CCDS20295.1
PIRⁱ	S43058
RefSeqⁱ	NP_031664.3, NM_007638.4
UniGeneⁱ	Mm.289900 Mm.456037

3D structure databases

ProteinModelPortalⁱ	P80313
SMRⁱ	P80313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198571, 29 interactors
CORUMⁱ	P80313
IntActⁱ	P80313, 29 interactors
MINTⁱ	P80313
STRINGⁱ	10090.ENSMUSP00000032078

PTM databases

iPTMnetⁱ	P80313
PhosphoSitePlusⁱ	P80313
SwissPalmⁱ	P80313

2D gel databases

REPRODUCTION-2DPAGEⁱ	P80313

REPRODUCTION-2DPAGEⁱ

P80313

Proteomic databases

EPDⁱ	P80313
PaxDbⁱ	P80313
PeptideAtlasⁱ	P80313
PRIDEⁱ	P80313

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032078; ENSMUSP00000032078; ENSMUSG00000030007
GeneIDⁱ	12468
KEGGⁱ	mmu:12468
UCSCⁱ	uc009cpv.2 mouse

Organism-specific databases

CTDⁱ	10574
MGIⁱ	MGI:107184 Cct7

Phylogenomic databases

eggNOGⁱ	KOG0360 Eukaryota COG0459 LUCA
GeneTreeⁱ	ENSGT00550000074832
HOGENOMⁱ	HOG000226730
HOVERGENⁱ	HBG001052
InParanoidⁱ	P80313
KOⁱ	K09499
OMAⁱ	QGCPNAK
OrthoDBⁱ	EOG091G05UO
PhylomeDBⁱ	P80313
TreeFamⁱ	TF105641

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSⁱ	Cct7 mouse
Protein Ontology More...PROⁱ	PR:P80313
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030007 Expressed in 295 organ(s), highest expression level in floor plate of midbrain
CleanExⁱ	MM_CCT7
ExpressionAtlasⁱ	P80313 baseline and differential
Genevisibleⁱ	P80313 MM

Family and domain databases

CDDⁱ	cd03340 TCP1_eta, 1 hit
Gene3Dⁱ	1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012720 Chap_CCT_eta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
PANTHERⁱ	PTHR11353:SF22 PTHR11353:SF22, 1 hit
Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02345 chap_CCT_eta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCPH_MOUSE
Accessionⁱ	P80313Primary (citable) accession number: P80313
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P80313 (TCPH_MOUSE)

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T-complex protein 1 subunit eta

Cct7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ