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Protein

Metallothionein-1H

Gene

MT1H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1H
Short name:
MT-1H
Alternative name(s):
Metallothionein-0
Short name:
MT-0
Metallothionein-IH
Short name:
MT-IH
Gene namesi
Name:MT1H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000205358.3
HGNCiHGNC:7400 MT1H
MIMi156354 gene
neXtProtiNX_P80294

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4496
OpenTargetsiENSG00000205358
PharmGKBiPA31205

Polymorphism and mutation databases

BioMutaiMT1H

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972391 – 61Metallothionein-1HAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine2 Publications1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP80294
MaxQBiP80294
PaxDbiP80294
PeptideAtlasiP80294
PRIDEiP80294
ProteomicsDBi57675

PTM databases

iPTMnetiP80294
PhosphoSitePlusiP80294

Expressioni

Gene expression databases

BgeeiENSG00000205358 Expressed in 228 organ(s), highest expression level in liver
CleanExiHS_MT1H
ExpressionAtlasiP80294 baseline and differential
GenevisibleiP80294 HS

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-296567,EBI-1182445

Protein-protein interaction databases

BioGridi110602, 2 interactors
IntActiP80294, 2 interactors
STRINGi9606.ENSP00000330587

Structurei

3D structure databases

ProteinModelPortaliP80294
SMRiP80294
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KC52 Eukaryota
ENOG41119WQ LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG094463
InParanoidiP80294
KOiK14739
OMAiCKGTETD
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P80294-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNCSCEAG GSCACAGSCK CKKCKCTSCK KSCCSCCPLG CAKCAQGCIC
60
KGASEKCSCC A
Length:61
Mass (Da):6,039
Last modified:February 1, 1994 - v1
Checksum:i03D866E4F437A2CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTC4H3BTC4_HUMAN
Metallothionein
MT1H
85Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64834 Genomic DNA Translation: CAA46046.1
X64177 mRNA Translation: CAA45516.1
BT007171 mRNA Translation: AAP35835.1
CH471092 Genomic DNA Translation: EAW82884.1
BC008408 mRNA Translation: AAH08408.1
BC059780 mRNA Translation: AAH59780.1
BC146930 mRNA Translation: AAI46931.1
BC146934 mRNA Translation: AAI46935.1
S68948 mRNA Translation: AAB30081.1
CCDSiCCDS10767.1
PIRiS47651
RefSeqiNP_005942.1, NM_005951.2
UniGeneiHs.438462

Genome annotation databases

EnsembliENST00000332374; ENSP00000330587; ENSG00000205358
GeneIDi4496
KEGGihsa:4496
UCSCiuc002ejw.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64834 Genomic DNA Translation: CAA46046.1
X64177 mRNA Translation: CAA45516.1
BT007171 mRNA Translation: AAP35835.1
CH471092 Genomic DNA Translation: EAW82884.1
BC008408 mRNA Translation: AAH08408.1
BC059780 mRNA Translation: AAH59780.1
BC146930 mRNA Translation: AAI46931.1
BC146934 mRNA Translation: AAI46935.1
S68948 mRNA Translation: AAB30081.1
CCDSiCCDS10767.1
PIRiS47651
RefSeqiNP_005942.1, NM_005951.2
UniGeneiHs.438462

3D structure databases

ProteinModelPortaliP80294
SMRiP80294
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110602, 2 interactors
IntActiP80294, 2 interactors
STRINGi9606.ENSP00000330587

PTM databases

iPTMnetiP80294
PhosphoSitePlusiP80294

Polymorphism and mutation databases

BioMutaiMT1H

Proteomic databases

EPDiP80294
MaxQBiP80294
PaxDbiP80294
PeptideAtlasiP80294
PRIDEiP80294
ProteomicsDBi57675

Protocols and materials databases

DNASUi4496
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332374; ENSP00000330587; ENSG00000205358
GeneIDi4496
KEGGihsa:4496
UCSCiuc002ejw.3 human

Organism-specific databases

CTDi4496
DisGeNETi4496
EuPathDBiHostDB:ENSG00000205358.3
GeneCardsiMT1H
H-InvDBiHIX0028598
HGNCiHGNC:7400 MT1H
MIMi156354 gene
neXtProtiNX_P80294
OpenTargetsiENSG00000205358
PharmGKBiPA31205
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC52 Eukaryota
ENOG41119WQ LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG094463
InParanoidiP80294
KOiK14739
OMAiCKGTETD
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

GeneWikiiMT1H
GenomeRNAii4496
PROiPR:P80294
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205358 Expressed in 228 organ(s), highest expression level in liver
CleanExiHS_MT1H
ExpressionAtlasiP80294 baseline and differential
GenevisibleiP80294 HS

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1H_HUMAN
AccessioniPrimary (citable) accession number: P80294
Secondary accession number(s): B2RUY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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