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Protein

Alcohol dehydrogenase 1

Gene
N/A
Organism
Alligator mississippiensis (American alligator)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei369NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi292 – 294NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase, major
OrganismiAlligator mississippiensis (American alligator)
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606751 – 374Alcohol dehydrogenase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP80222

Structurei

3D structure databases

ProteinModelPortaliP80222
SMRiP80222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P80222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
STAGKVIKCK AAITWEIKKP FSIEEIEVAP PKAHEVRIKI LATGICRSDD
60 70 80 90 100
HVTAGLLTMP LPMILGHEAA GVVESTGEGV TSLKPGDKVI PLFVPQCGEC
110 120 130 140 150
MPCLKSNGNL CIRNDLGSPS GLMADGTSRF TCKGKDIHHF IGTSTFTEYT
160 170 180 190 200
VVHETAVARI DAAAPLEKVC LIGCGFSTGY GAAVKDAKVE PGSTCAVFGL
210 220 230 240 250
GGVGLSTIMG CKAAGASRII GIDINKDKFA KAKELGATEC INPLDCKKPI
260 270 280 290 300
QEVLSEMTGG GVDYSFEVIG RIDTMTAALA CCQDNYGTSV IVGVPPASEK
310 320 330 340 350
ITFNPMMLFT GRTWKGSVFG GWKSKESVPK LVADYMEKKI NLDGLITHTL
360 370
PFDKINEGFE LLRTGKSIRS VLTF
Length:374
Mass (Da):39,670
Last modified:October 1, 1993 - v1
Checksum:i384BCB2D36E2FA32
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti186D → T. 1
Natural varianti317S → T. 1

Sequence databases

PIRiS35669

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS35669

3D structure databases

ProteinModelPortaliP80222
SMRiP80222
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP80222

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_ALLMI
AccessioniPrimary (citable) accession number: P80222
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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