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Protein

Homeobox protein OTX2

Gene

Otx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 97HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX2
Alternative name(s):
Orthodenticle homolog 2
Gene namesi
Name:Otx2
Synonyms:Otx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97451 Otx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi225N → S: Has a dominant negative effect on the proximal promoter region of HESX1 gene; represses reporter expression. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492111 – 289Homeobox protein OTX2Add BLAST289

Proteomic databases

PaxDbiP80206
PRIDEiP80206

PTM databases

iPTMnetiP80206
PhosphoSitePlusiP80206

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Embryo.

Gene expression databases

CleanExiMM_OTX2

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiP80206
STRINGi10090.ENSMUSP00000113690

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80206
SMRiP80206
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80206

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiP80206
PhylomeDBiP80206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003022 Otx2_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01257 OTX2HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P80206-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ
110 120 130 140 150
QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FTPPSSTSVP TIASSSAPVS
160 170 180 190 200
IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD
210 220 230 240 250
CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST QGYGASSLGF
260 270 280
NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL
Length:289
Mass (Da):31,622
Last modified:October 1, 1993 - v1
Checksum:iB4EA3A5BF83E2D99
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R0B5Q8R0B5_MOUSE
Homeobox protein OTX2
Otx2
297Annotation score:
Q8VD35Q8VD35_MOUSE
Homeobox protein OTX2
Otx2 mCG_12117
289Annotation score:
D3YZ94D3YZ94_MOUSE
Homeobox protein OTX2
Otx2
207Annotation score:
D3Z7L5D3Z7L5_MOUSE
Homeobox protein OTX2
Otx2
63Annotation score:
D3Z4G2D3Z4G2_MOUSE
Homeobox protein OTX2
Otx2
98Annotation score:
D3Z581D3Z581_MOUSE
Homeobox protein OTX2
Otx2
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68884 mRNA Translation: CAA48755.1
CCDSiCCDS49473.1
PIRiS35346
UniGeneiMm.134516
Mm.487292

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68884 mRNA Translation: CAA48755.1
CCDSiCCDS49473.1
PIRiS35346
UniGeneiMm.134516
Mm.487292

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMSNMR-A39-105[»]
ProteinModelPortaliP80206
SMRiP80206
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP80206
STRINGi10090.ENSMUSP00000113690

PTM databases

iPTMnetiP80206
PhosphoSitePlusiP80206

Proteomic databases

PaxDbiP80206
PRIDEiP80206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97451 Otx2

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiP80206
PhylomeDBiP80206

Miscellaneous databases

ChiTaRSiOtx2 mouse
EvolutionaryTraceiP80206
PROiPR:P80206
SOURCEiSearch...

Gene expression databases

CleanExiMM_OTX2

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003022 Otx2_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01257 OTX2HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOTX2_MOUSE
AccessioniPrimary (citable) accession number: P80206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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