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Protein

Homeobox protein OTX1

Gene

Otx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 97HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • diencephalon morphogenesis Source: MGI
  • forebrain development Source: MGI
  • inner ear morphogenesis Source: MGI
  • metencephalon development Source: MGI
  • midbrain development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:Otx1
Synonyms:Otx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97450 Otx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492081 – 355Homeobox protein OTX1Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP80205
PRIDEiP80205

PTM databases

iPTMnetiP80205
PhosphoSitePlusiP80205

Expressioni

Tissue specificityi

Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSMUSG00000005917 Expressed in 144 organ(s), highest expression level in embryo
CleanExiMM_OTX1
ExpressionAtlasiP80205 baseline and differential
GenevisibleiP80205 MM

Interactioni

Protein-protein interaction databases

BioGridi201992, 1 interactor
STRINGi10090.ENSMUSP00000006071

Structurei

3D structure databases

ProteinModelPortaliP80205
SMRiP80205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi275 – 302His-richAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00930000150828
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiP80205
KOiK09326
OMAiYGVNGLG
OrthoDBiEOG091G0K9K
PhylomeDBiP80205
TreeFamiTF351179

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003026 Otx1_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01256 OTX1HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P80205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP
210 220 230 240 250
SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW

RFQVL
Length:355
Mass (Da):37,532
Last modified:October 1, 1993 - v1
Checksum:iDA5136D9D4FC948F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V000G3V000_MOUSE
Homeobox protein OTX1
Otx1
150Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057105 mRNA Translation: AAH57105.1
BC058354 mRNA Translation: AAH58354.1
X68883 mRNA Translation: CAA48754.1
CCDSiCCDS24468.1
PIRiS35345
RefSeqiNP_035153.1, NM_011023.3
XP_017169827.1, XM_017314338.1
UniGeneiMm.129663

Genome annotation databases

EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917
GeneIDi18423
KEGGimmu:18423
UCSCiuc007idy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057105 mRNA Translation: AAH57105.1
BC058354 mRNA Translation: AAH58354.1
X68883 mRNA Translation: CAA48754.1
CCDSiCCDS24468.1
PIRiS35345
RefSeqiNP_035153.1, NM_011023.3
XP_017169827.1, XM_017314338.1
UniGeneiMm.129663

3D structure databases

ProteinModelPortaliP80205
SMRiP80205
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201992, 1 interactor
STRINGi10090.ENSMUSP00000006071

PTM databases

iPTMnetiP80205
PhosphoSitePlusiP80205

Proteomic databases

PaxDbiP80205
PRIDEiP80205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917
GeneIDi18423
KEGGimmu:18423
UCSCiuc007idy.1 mouse

Organism-specific databases

CTDi5013
MGIiMGI:97450 Otx1

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00930000150828
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiP80205
KOiK09326
OMAiYGVNGLG
OrthoDBiEOG091G0K9K
PhylomeDBiP80205
TreeFamiTF351179

Miscellaneous databases

PROiPR:P80205
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005917 Expressed in 144 organ(s), highest expression level in embryo
CleanExiMM_OTX1
ExpressionAtlasiP80205 baseline and differential
GenevisibleiP80205 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003026 Otx1_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01256 OTX1HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOTX1_MOUSE
AccessioniPrimary (citable) accession number: P80205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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