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UniProtKB - P80205 (OTX1_MOUSE)
Protein
Homeobox protein OTX1
Gene
Otx1
Organism
Mus musculus (Mouse)
Status
Functioni
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 97 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- diencephalon morphogenesis Source: MGI
- forebrain development Source: MGI
- inner ear morphogenesis Source: MGI
- metencephalon development Source: MGI
- midbrain development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein OTX1Alternative name(s): Orthodenticle homolog 1 |
Gene namesi | Name:Otx1 Synonyms:Otx-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97450, Otx1 |
VEuPathDBi | HostDB:ENSMUSG00000005917 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049208 | 1 – 355 | Homeobox protein OTX1Add BLAST | 355 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 345 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P80205 |
PRIDEi | P80205 |
ProteomicsDBi | 294407 |
PTM databases
iPTMneti | P80205 |
PhosphoSitePlusi | P80205 |
Expressioni
Tissue specificityi
Brain: restricted regions of the developing rostral brain including the presumptive cerebral cortex and olfactory bulbs; expressed in the developing olfactory, auricolar and ocular systems, including the covering of the optic nerve.
Developmental stagei
Embryo.
Gene expression databases
Bgeei | ENSMUSG00000005917, Expressed in embryo and 163 other tissues |
ExpressionAtlasi | P80205, baseline and differential |
Genevisiblei | P80205, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 201992, 1 interactor |
STRINGi | 10090.ENSMUSP00000006071 |
Miscellaneous databases
RNActi | P80205, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 144 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 257 – 306 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 91 – 108 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 117 – 144 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 274 – 304 | Basic residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG2251, Eukaryota |
GeneTreei | ENSGT00940000161234 |
HOGENOMi | CLU_064370_0_0_1 |
InParanoidi | P80205 |
OMAi | PTMDLLH |
OrthoDBi | 1481439at2759 |
PhylomeDBi | P80205 |
TreeFami | TF351179 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003026, Otx1_TF IPR003025, Otx_TF IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
PRINTSi | PR01256, OTX1HOMEOBOX PR01255, OTXHOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P80205-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
NGTKTRPVKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSASANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PTASSIWSPA SISPGSAPTS VSVPEPLAAP
210 220 230 240 250
SNASCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPAPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HHQGYGGSGL AFNSADCLDY KEPAAAAASS AWKLNFNSPD CLDYKDQASW
RFQVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V000 | G3V000_MOUSE | Homeobox protein OTX1 | Otx1 | 150 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057105 mRNA Translation: AAH57105.1 BC058354 mRNA Translation: AAH58354.1 X68883 mRNA Translation: CAA48754.1 |
CCDSi | CCDS24468.1 |
PIRi | S35345 |
RefSeqi | NP_035153.1, NM_011023.3 XP_017169827.1, XM_017314338.1 |
Genome annotation databases
Ensembli | ENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917 |
GeneIDi | 18423 |
KEGGi | mmu:18423 |
UCSCi | uc007idy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC057105 mRNA Translation: AAH57105.1 BC058354 mRNA Translation: AAH58354.1 X68883 mRNA Translation: CAA48754.1 |
CCDSi | CCDS24468.1 |
PIRi | S35345 |
RefSeqi | NP_035153.1, NM_011023.3 XP_017169827.1, XM_017314338.1 |
3D structure databases
AlphaFoldDBi | P80205 |
SMRi | P80205 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201992, 1 interactor |
STRINGi | 10090.ENSMUSP00000006071 |
PTM databases
iPTMneti | P80205 |
PhosphoSitePlusi | P80205 |
Proteomic databases
PaxDbi | P80205 |
PRIDEi | P80205 |
ProteomicsDBi | 294407 |
Protocols and materials databases
Antibodypediai | 3233, 274 antibodies from 28 providers |
DNASUi | 18423 |
Genome annotation databases
Ensembli | ENSMUST00000006071; ENSMUSP00000006071; ENSMUSG00000005917 |
GeneIDi | 18423 |
KEGGi | mmu:18423 |
UCSCi | uc007idy.1, mouse |
Organism-specific databases
CTDi | 5013 |
MGIi | MGI:97450, Otx1 |
VEuPathDBi | HostDB:ENSMUSG00000005917 |
Phylogenomic databases
eggNOGi | KOG2251, Eukaryota |
GeneTreei | ENSGT00940000161234 |
HOGENOMi | CLU_064370_0_0_1 |
InParanoidi | P80205 |
OMAi | PTMDLLH |
OrthoDBi | 1481439at2759 |
PhylomeDBi | P80205 |
TreeFami | TF351179 |
Miscellaneous databases
BioGRID-ORCSi | 18423, 1 hit in 74 CRISPR screens |
PROi | PR:P80205 |
RNActi | P80205, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005917, Expressed in embryo and 163 other tissues |
ExpressionAtlasi | P80205, baseline and differential |
Genevisiblei | P80205, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003026, Otx1_TF IPR003025, Otx_TF IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
PRINTSi | PR01256, OTX1HOMEOBOX PR01255, OTXHOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OTX1_MOUSE | |
Accessioni | P80205Primary (citable) accession number: P80205 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families