UniProtKB - P80204 (TGFR1_RAT)
TGF-beta receptor type-1
Tgfbr1
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 230 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 331 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 209 – 217 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin binding Source: GO_Central
- activin receptor activity, type I Source: GO_Central
- ATP binding Source: RGD
- I-SMAD binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: RGD
- protein kinase activity Source: RGD
- protein serine/threonine kinase activity Source: RGD
- signaling receptor binding Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta-activated receptor activity Source: RGD
- transforming growth factor beta binding Source: RGD
- transforming growth factor beta receptor activity, type I Source: RGD
- type II transforming growth factor beta receptor binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
GO - Biological processi
- activation of MAPKK activity Source: RGD
- activin receptor signaling pathway Source: AgBase
- aging Source: RGD
- angiogenesis Source: RGD
- angiogenesis involved in coronary vascular morphogenesis Source: RGD
- animal organ regeneration Source: RGD
- anterior/posterior pattern specification Source: RGD
- apoptotic process Source: UniProtKB-KW
- artery morphogenesis Source: RGD
- blastocyst development Source: RGD
- cardiac epithelial to mesenchymal transition Source: AgBase
- cell motility Source: RGD
- cellular response to growth factor stimulus Source: GO_Central
- cellular response to transforming growth factor beta stimulus Source: RGD
- collagen fibril organization Source: RGD
- coronary artery morphogenesis Source: RGD
- digestive tract development Source: RGD
- embryo implantation Source: RGD
- embryonic cranial skeleton morphogenesis Source: RGD
- endothelial cell activation Source: AgBase
- endothelial cell migration Source: RGD
- epicardium morphogenesis Source: RGD
- epithelial to mesenchymal transition Source: RGD
- germ cell migration Source: RGD
- heart development Source: AgBase
- intracellular signal transduction Source: AgBase
- in utero embryonic development Source: RGD
- kidney development Source: RGD
- lens development in camera-type eye Source: RGD
- lung development Source: RGD
- male gonad development Source: RGD
- mesenchymal cell differentiation Source: AgBase
- negative regulation of apoptotic process Source: RGD
- negative regulation of chondrocyte differentiation Source: RGD
- negative regulation of endothelial cell differentiation Source: RGD
- negative regulation of endothelial cell proliferation Source: RGD
- negative regulation of extrinsic apoptotic signaling pathway Source: RGD
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- nervous system development Source: GO_Central
- neuron fate commitment Source: RGD
- parathyroid gland development Source: RGD
- pathway-restricted SMAD protein phosphorylation Source: RGD
- peptidyl-serine phosphorylation Source: RGD
- peptidyl-threonine phosphorylation Source: RGD
- pharyngeal system development Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of apoptotic signaling pathway Source: RGD
- positive regulation of cell growth Source: RGD
- positive regulation of cell migration Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cellular component movement Source: RGD
- positive regulation of endothelial cell proliferation Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: RGD
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- positive regulation of filopodium assembly Source: RGD
- positive regulation of gene expression Source: AgBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: RGD
- positive regulation of SMAD protein signal transduction Source: RGD
- positive regulation of stress fiber assembly Source: RGD
- positive regulation of tight junction disassembly Source: RGD
- positive regulation of transcription, DNA-templated Source: AgBase
- post-embryonic development Source: RGD
- protein autophosphorylation Source: RGD
- protein phosphorylation Source: RGD
- regulation of cardiac muscle cell proliferation Source: RGD
- regulation of epithelial to mesenchymal transition Source: AgBase
- regulation of gene expression Source: AgBase
- regulation of protein binding Source: RGD
- regulation of protein ubiquitination Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- response to cholesterol Source: RGD
- response to electrical stimulus Source: RGD
- response to estrogen Source: RGD
- response to hypoxia Source: RGD
- response to organic cyclic compound Source: RGD
- response to prostaglandin E Source: RGD
- response to toxic substance Source: RGD
- roof of mouth development Source: RGD
- signal transduction Source: RGD
- skeletal system development Source: RGD
- skeletal system morphogenesis Source: RGD
- thymus development Source: RGD
- transforming growth factor beta receptor signaling pathway Source: RGD
- ventricular compact myocardium morphogenesis Source: RGD
- ventricular septum morphogenesis Source: RGD
- ventricular trabecula myocardium morphogenesis Source: RGD
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Differentiation, Growth regulation |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 2.7.11.30, 5301 |
Reactomei | R-RNO-2173788, Downregulation of TGF-beta receptor signaling R-RNO-2173789, TGF-beta receptor signaling activates SMADs R-RNO-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-RNO-5689880, Ub-specific processing proteases |
Names & Taxonomyi
Protein namesi | Recommended name: TGF-beta receptor type-1 (EC:2.7.11.30)Short name: TGFR-1 Alternative name(s): Serine/threonine-protein kinase receptor R4 Short name: SKR4 TGF-beta type I receptor Transforming growth factor-beta receptor type I Short name: TGF-beta receptor type I Short name: TbetaR-I |
Gene namesi | Name:Tgfbr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3852, Tgfbr1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- tight junction By similarity
- Membrane raft By similarity
- Cell surface By similarity
Endosome
- endosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- activin receptor complex Source: GO_Central
- apical plasma membrane Source: RGD
- basolateral plasma membrane Source: RGD
- caveola Source: MGI
- plasma membrane Source: RGD
Other locations
- bicellular tight junction Source: RGD
- cell surface Source: UniProtKB
- membrane raft Source: MGI
- protein-containing complex Source: RGD
- receptor complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 124 | ExtracellularSequence analysisAdd BLAST | 95 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 501 | CytoplasmicSequence analysisAdd BLAST | 356 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | By similarityAdd BLAST | 29 | |
ChainiPRO_0000024425 | 30 – 501 | TGF-beta receptor type-1Add BLAST | 472 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 50 | By similarity | ||
Disulfide bondi | 34 ↔ 37 | By similarity | ||
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 44 ↔ 67 | By similarity | ||
Disulfide bondi | 82 ↔ 94 | By similarity | ||
Disulfide bondi | 95 ↔ 100 | By similarity | ||
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Modified residuei | 183 | Phosphothreonine; by TGFBR2By similarity | 1 | |
Modified residuei | 184 | Phosphothreonine; by TGFBR2By similarity | 1 | |
Modified residuei | 185 | Phosphoserine; by TGFBR2By similarity | 1 | |
Modified residuei | 187 | Phosphoserine; by TGFBR2By similarity | 1 | |
Modified residuei | 189 | Phosphoserine; by TGFBR2By similarity | 1 | |
Cross-linki | 389 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P80204 |
PRIDEi | P80204 |
PTM databases
GlyGeni | P80204, 1 site |
PhosphoSitePlusi | P80204 |
Expressioni
Tissue specificityi
Gene expression databases
Genevisiblei | P80204, RN |
Interactioni
Subunit structurei
Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3.
Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes.
Interacts with RBPMS.
Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor.
Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6.
Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition.
Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor (By similarity).
Interacts with USP15 and VPS39 (By similarity).
Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation.
Interacts with SDCBP (via C-terminus).
Interacts with CAV1 and this interaction is impaired in the presence of SDCBP (By similarity).
Interacts with APPL1; interaction is TGF beta dependent; mediates trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (By similarity).
By similarity1 PublicationGO - Molecular functioni
- I-SMAD binding Source: RGD
- signaling receptor binding Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta binding Source: RGD
- type II transforming growth factor beta receptor binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 248223, 2 interactors |
CORUMi | P80204 |
IntActi | P80204, 4 interactors |
MINTi | P80204 |
STRINGi | 10116.ENSRNOP00000009452 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 173 – 202 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 203 – 493 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 291 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 191 – 192 | FKBP1A-binding | 2 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P80204 |
OrthoDBi | 776697at2759 |
PhylomeDBi | P80204 |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEAASAALRR CLLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC
60 70 80 90 100
FVSVTETTDK VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTYCCNQDHC
110 120 130 140 150
NKIELPTTGP FSEKQSAGLG PVELAAVIAG PVCFVCIALM LMVYICHNRT
160 170 180 190 200
VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY DMTTSGSGSG LPLLVQRTIA
210 220 230 240 250
RTIVLQESIG KGRFGEVWRG KWRGEEVAVK IFSSREERSW FREAEIYQTV
260 270 280 290 300
MLRHENILGF IAADNKDNGT WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM
310 320 330 340 350
IKLALSTASG LAHLHMEIVG TQGKPAIAHR DLKSKNILVK KNGTCCIADL
360 370 380 390 400
GLAVRHDSAT DTIDIAPNHR VGTKRYMAPE VLDDSINMKH FESFKRADIY
410 420 430 440 450
AMGLVFWEIA RRCSIGGIHE DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP
460 470 480 490 500
NIPNRWQSCE ALRVMAKIMR ECWYANGAAR LTALRIKKTL SQLSQQEGIK
M
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5M9H3 | Q5M9H3_RAT | Receptor protein serine/threonine k... | Tgfbr1 | 497 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26110 mRNA Translation: AAA83216.1 |
RefSeqi | XP_006238092.2, XM_006238030.3 |
Genome annotation databases
GeneIDi | 29591 |
UCSCi | RGD:3852, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26110 mRNA Translation: AAA83216.1 |
RefSeqi | XP_006238092.2, XM_006238030.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 248223, 2 interactors |
CORUMi | P80204 |
IntActi | P80204, 4 interactors |
MINTi | P80204 |
STRINGi | 10116.ENSRNOP00000009452 |
PTM databases
GlyGeni | P80204, 1 site |
PhosphoSitePlusi | P80204 |
Proteomic databases
PaxDbi | P80204 |
PRIDEi | P80204 |
Genome annotation databases
GeneIDi | 29591 |
UCSCi | RGD:3852, rat |
Organism-specific databases
CTDi | 7046 |
RGDi | 3852, Tgfbr1 |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P80204 |
OrthoDBi | 776697at2759 |
PhylomeDBi | P80204 |
TreeFami | TF314724 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 2.7.11.30, 5301 |
Reactomei | R-RNO-2173788, Downregulation of TGF-beta receptor signaling R-RNO-2173789, TGF-beta receptor signaling activates SMADs R-RNO-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-RNO-5689880, Ub-specific processing proteases |
Miscellaneous databases
PROi | PR:P80204 |
Gene expression databases
Genevisiblei | P80204, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFR1_RAT | |
Accessioni | P80204Primary (citable) accession number: P80204 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families