UniProtKB - P80203 (ACVL1_RAT)
Protein
Serine/threonine-protein kinase receptor R3
Gene
Acvrl1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.By similarity
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 230 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 331 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 209 – 217 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin binding Source: RGD
- activin receptor activity, type I Source: RGD
- ATP binding Source: RGD
- BMP receptor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein kinase binding Source: RGD
- protein serine/threonine kinase activity Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta-activated receptor activity Source: RGD
- transforming growth factor beta binding Source: RGD
- transforming growth factor beta receptor activity, type I Source: RGD
- transmembrane receptor protein serine/threonine kinase activity Source: RGD
GO - Biological processi
- angiogenesis Source: RGD
- artery development Source: RGD
- blood circulation Source: RGD
- blood vessel morphogenesis Source: RGD
- blood vessel remodeling Source: RGD
- BMP signaling pathway Source: RGD
- cellular response to BMP stimulus Source: RGD
- cellular response to growth factor stimulus Source: GO_Central
- cellular response to transforming growth factor beta stimulus Source: RGD
- dorsal/ventral pattern formation Source: GO_Central
- dorsal aorta morphogenesis Source: RGD
- endocardial cushion morphogenesis Source: RGD
- endothelial tube morphogenesis Source: RGD
- heart development Source: GO_Central
- in utero embryonic development Source: RGD
- lymphangiogenesis Source: RGD
- lymphatic endothelial cell differentiation Source: RGD
- negative regulation of blood vessel endothelial cell migration Source: RGD
- negative regulation of cell adhesion Source: RGD
- negative regulation of cell growth Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of DNA biosynthetic process Source: RGD
- negative regulation of endothelial cell differentiation Source: RGD
- negative regulation of endothelial cell migration Source: RGD
- negative regulation of endothelial cell proliferation Source: RGD
- negative regulation of focal adhesion assembly Source: RGD
- negative regulation of gene expression Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of BMP signaling pathway Source: RGD
- positive regulation of endothelial cell differentiation Source: RGD
- positive regulation of endothelial cell proliferation Source: RGD
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein phosphorylation Source: RGD
- regulation of blood pressure Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- response to hypoxia Source: RGD
- retina vasculature development in camera-type eye Source: RGD
- signal transduction Source: RGD
- transforming growth factor beta receptor signaling pathway Source: RGD
- venous blood vessel development Source: RGD
- wound healing, spreading of epidermal cells Source: RGD
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Angiogenesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 |
Reactomei | R-RNO-201451, Signaling by BMP |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)Short name: SKR3 Alternative name(s): TGF-B superfamily receptor type I Short name: TSR-I |
Gene namesi | Name:Acvrl1 Synonyms:Acvrlk1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2029, Acvrl1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- BMP receptor complex Source: GO_Central
- integral component of plasma membrane Source: RGD
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: RGD
- dendrite Source: RGD
- neuronal cell body Source: RGD
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 121 | ExtracellularSequence analysisAdd BLAST | 101 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 143 – 504 | CytoplasmicSequence analysisAdd BLAST | 362 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000024422 | 21 – 504 | Serine/threonine-protein kinase receptor R3Add BLAST | 484 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 35 ↔ 52 | By similarity | ||
Disulfide bondi | 37 ↔ 42 | By similarity | ||
Disulfide bondi | 47 ↔ 70 | By similarity | ||
Disulfide bondi | 78 ↔ 90 | By similarity | ||
Disulfide bondi | 91 ↔ 96 | By similarity | ||
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P80203 |
PRIDEi | P80203 |
PTM databases
GlyGeni | P80203, 2 sites |
iPTMneti | P80203 |
PhosphoSitePlusi | P80203 |
Expressioni
Tissue specificityi
Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000028713, Expressed in lung and 22 other tissues |
Genevisiblei | P80203, RN |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008673 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 173 – 202 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 203 – 504 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 302 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 74 – 77 | Mediates specificity for BMP ligandBy similarity | 4 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P80203 |
OMAi | DPTYGEI |
OrthoDBi | 776697at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P80203-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA
60 70 80 90 100
WCTVVLVREQ GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV
110 120 130 140 150
SLMLEATQTP SEEPEVDAHL PLILGPVLAL LVLVALGTLG LWRVRRRQEK
160 170 180 190 200
QRGLHSDLGE SSLILKASEQ GDSMLGDFLV SDCTTGSGSG LPFLVQRTVA
210 220 230 240 250
RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW FRETEIYNTV
260 270 280 290 300
LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA
310 320 330 340 350
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL
360 370 380 390 400
GLAVMHSQSS DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW
410 420 430 440 450
AFGLVLWEIA RRTIINGIVE DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP
460 470 480 490 500
TIPNRLAADP VLSGLAQMMR ECWYPNPSAR LTALRIKKTL QKLSQNPEKP
KVIH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 309 | C → CA (PubMed:8395914).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36088 mRNA Translation: AAC37705.1 BC083173 mRNA Translation: AAH83173.1 |
RefSeqi | NP_071886.1, NM_022441.2 XP_006242365.1, XM_006242303.3 XP_006242366.1, XM_006242304.3 XP_006242367.1, XM_006242305.3 XP_008763895.1, XM_008765673.2 XP_017450156.1, XM_017594667.1 XP_017450157.1, XM_017594668.1 |
Genome annotation databases
Ensembli | ENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713 ENSRNOT00000081047; ENSRNOP00000072526; ENSRNOG00000028713 |
GeneIDi | 25237 |
KEGGi | rno:25237 |
UCSCi | RGD:2029, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36088 mRNA Translation: AAC37705.1 BC083173 mRNA Translation: AAH83173.1 |
RefSeqi | NP_071886.1, NM_022441.2 XP_006242365.1, XM_006242303.3 XP_006242366.1, XM_006242304.3 XP_006242367.1, XM_006242305.3 XP_008763895.1, XM_008765673.2 XP_017450156.1, XM_017594667.1 XP_017450157.1, XM_017594668.1 |
3D structure databases
SMRi | P80203 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008673 |
PTM databases
GlyGeni | P80203, 2 sites |
iPTMneti | P80203 |
PhosphoSitePlusi | P80203 |
Proteomic databases
PaxDbi | P80203 |
PRIDEi | P80203 |
Genome annotation databases
Ensembli | ENSRNOT00000008673; ENSRNOP00000008673; ENSRNOG00000028713 ENSRNOT00000081047; ENSRNOP00000072526; ENSRNOG00000028713 |
GeneIDi | 25237 |
KEGGi | rno:25237 |
UCSCi | RGD:2029, rat |
Organism-specific databases
CTDi | 94 |
RGDi | 2029, Acvrl1 |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P80203 |
OMAi | DPTYGEI |
OrthoDBi | 776697at2759 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 5301 |
Reactomei | R-RNO-201451, Signaling by BMP |
Miscellaneous databases
PROi | PR:P80203 |
Gene expression databases
Bgeei | ENSRNOG00000028713, Expressed in lung and 22 other tissues |
Genevisiblei | P80203, RN |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACVL1_RAT | |
Accessioni | P80203Primary (citable) accession number: P80203 Secondary accession number(s): Q63559 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families