Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C motif chemokine 6

Gene

CXCL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).4 Publications

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Cytokine, Heparin-binding
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 6
Alternative name(s):
Chemokine alpha 3
Short name:
CKA-3
Granulocyte chemotactic protein 2
Short name:
GCP-2
Small-inducible cytokine B6
Cleaved into the following 3 chains:
Gene namesi
Name:CXCL6
Synonyms:GCP2, SCYB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000124875.9
HGNCiHGNC:10643 CXCL6
MIMi138965 gene
neXtProtiNX_P80162

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6372
OpenTargetsiENSG00000124875
PharmGKBiPA35574

Polymorphism and mutation databases

BioMutaiCXCL6
DMDMi2851486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 372 PublicationsAdd BLAST37
ChainiPRO_000000508438 – 114C-X-C motif chemokine 6Add BLAST77
ChainiPRO_000000508540 – 114Small-inducible cytokine B6, N-processed variant 1Add BLAST75
ChainiPRO_000000508643 – 114Small-inducible cytokine B6, N-processed variant 2Add BLAST72
ChainiPRO_000000508746 – 114Small-inducible cytokine B6, N-processed variant 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 75By similarity
Disulfide bondi51 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP80162
PaxDbiP80162
PeptideAtlasiP80162
PRIDEiP80162
ProteomicsDBi57668

PTM databases

iPTMnetiP80162
PhosphoSitePlusiP80162

Miscellaneous databases

PMAP-CutDBiP80162

Expressioni

Gene expression databases

BgeeiENSG00000124875 Expressed in 117 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL6
ExpressionAtlasiP80162 baseline and differential
GenevisibleiP80162 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112274, 1 interactor
IntActiP80162, 12 interactors
MINTiP80162
STRINGi9606.ENSP00000226317

Structurei

3D structure databases

ProteinModelPortaliP80162
SMRiP80162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR Eukaryota
ENOG41117DC LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP80162
KOiK05506
OMAiTELRCTC
OrthoDBiEOG091G132U
PhylomeDBiP80162
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P80162-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT
60 70 80 90 100
CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK
110
KVIQKILDSG NKKN
Length:114
Mass (Da):11,897
Last modified:July 15, 1998 - v4
Checksum:i5A58B38C17F25178
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF92D6RF92_HUMAN
C-X-C motif chemokine
CXCL6
113Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83303 Genomic DNA Translation: AAC51338.1
U81234 mRNA Translation: AAD00506.1
AK311981 mRNA Translation: BAG34920.1
AC108029 Genomic DNA Translation: AAY40939.1
BC013744 mRNA Translation: AAH13744.1
Y08770 mRNA Translation: CAA70023.1
CCDSiCCDS3560.1
PIRiA54188
RefSeqiNP_002984.1, NM_002993.3
UniGeneiHs.164021

Genome annotation databases

EnsembliENST00000226317; ENSP00000226317; ENSG00000124875
GeneIDi6372
KEGGihsa:6372
UCSCiuc003hhf.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL6 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83303 Genomic DNA Translation: AAC51338.1
U81234 mRNA Translation: AAD00506.1
AK311981 mRNA Translation: BAG34920.1
AC108029 Genomic DNA Translation: AAY40939.1
BC013744 mRNA Translation: AAH13744.1
Y08770 mRNA Translation: CAA70023.1
CCDSiCCDS3560.1
PIRiA54188
RefSeqiNP_002984.1, NM_002993.3
UniGeneiHs.164021

3D structure databases

ProteinModelPortaliP80162
SMRiP80162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112274, 1 interactor
IntActiP80162, 12 interactors
MINTiP80162
STRINGi9606.ENSP00000226317

PTM databases

iPTMnetiP80162
PhosphoSitePlusiP80162

Polymorphism and mutation databases

BioMutaiCXCL6
DMDMi2851486

Proteomic databases

MaxQBiP80162
PaxDbiP80162
PeptideAtlasiP80162
PRIDEiP80162
ProteomicsDBi57668

Protocols and materials databases

DNASUi6372
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226317; ENSP00000226317; ENSG00000124875
GeneIDi6372
KEGGihsa:6372
UCSCiuc003hhf.4 human

Organism-specific databases

CTDi6372
DisGeNETi6372
EuPathDBiHostDB:ENSG00000124875.9
GeneCardsiCXCL6
HGNCiHGNC:10643 CXCL6
MIMi138965 gene
neXtProtiNX_P80162
OpenTargetsiENSG00000124875
PharmGKBiPA35574
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4TR Eukaryota
ENOG41117DC LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP80162
KOiK05506
OMAiTELRCTC
OrthoDBiEOG091G132U
PhylomeDBiP80162
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GenomeRNAii6372
PMAP-CutDBiP80162
PROiPR:P80162
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124875 Expressed in 117 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL6
ExpressionAtlasiP80162 baseline and differential
GenevisibleiP80162 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL6_HUMAN
AccessioniPrimary (citable) accession number: P80162
Secondary accession number(s): B2R4X3, Q4W5D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again