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UniProtKB - P80162 (CXCL6_HUMAN)
Protein
C-X-C motif chemokine 6
Gene
CXCL6
Organism
Homo sapiens (Human)
Status
Functioni
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
4 PublicationsGO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cell-cell signaling Source: ProtInc
- cellular response to lipopolysaccharide Source: UniProtKB
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: ProtInc
- defense response to bacterium Source: UniProtKB-KW
- inflammatory response Source: GO_Central
- leukocyte homeostasis Source: Ensembl
- neutrophil activation Source: UniProtKB
- neutrophil chemotaxis Source: UniProtKB
- regulation of chemokine production Source: Ensembl
- regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Cytokine, Heparin-binding |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P80162 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P80162 |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 6Alternative name(s): Chemokine alpha 3 Short name: CKA-3 Granulocyte chemotactic protein 2 Short name: GCP-2 Small-inducible cytokine B6 Cleaved into the following 3 chains: |
Gene namesi | Name:CXCL6 Synonyms:GCP2, SCYB6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10643, CXCL6 |
MIMi | 138965, gene |
neXtProti | NX_P80162 |
VEuPathDBi | HostDB:ENSG00000124875 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6372 |
OpenTargetsi | ENSG00000124875 |
PharmGKBi | PA35574 |
Miscellaneous databases
Pharosi | P80162, Tbio |
Genetic variation databases
BioMutai | CXCL6 |
DMDMi | 2851486 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | 2 PublicationsAdd BLAST | 37 | |
ChainiPRO_0000005084 | 38 – 114 | C-X-C motif chemokine 6Add BLAST | 77 | |
ChainiPRO_0000005085 | 40 – 114 | Small-inducible cytokine B6, N-processed variant 1Add BLAST | 75 | |
ChainiPRO_0000005086 | 43 – 114 | Small-inducible cytokine B6, N-processed variant 2Add BLAST | 72 | |
ChainiPRO_0000005087 | 46 – 114 | Small-inducible cytokine B6, N-processed variant 3Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 75 | By similarity | ||
Disulfide bondi | 51 ↔ 91 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P80162 |
MaxQBi | P80162 |
PaxDbi | P80162 |
PeptideAtlasi | P80162 |
PRIDEi | P80162 |
ProteomicsDBi | 57668 |
PTM databases
iPTMneti | P80162 |
PhosphoSitePlusi | P80162 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124875, Expressed in smooth muscle tissue and 133 other tissues |
ExpressionAtlasi | P80162, baseline and differential |
Genevisiblei | P80162, HS |
Organism-specific databases
HPAi | ENSG00000124875, Group enriched (gallbladder, lymphoid tissue, urinary bladder) |
Interactioni
Binary interactionsi
P80162
With | #Exp. | IntAct |
---|---|---|
CCL5 [P13501] | 2 | EBI-9214033,EBI-2848366 |
CXCL12 [P48061] | 2 | EBI-9214033,EBI-3913254 |
PF4 [P02776] | 2 | EBI-9214033,EBI-2565740 |
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112274, 34 interactors |
IntActi | P80162, 12 interactors |
MINTi | P80162 |
STRINGi | 9606.ENSP00000226317 |
Miscellaneous databases
RNActi | P80162, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000162749 |
InParanoidi | P80162 |
OMAi | KELRCTC |
OrthoDBi | 1556509at2759 |
PhylomeDBi | P80162 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P80162-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT
60 70 80 90 100
CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK
110
KVIQKILDSG NKKN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RF92 | D6RF92_HUMAN | C-X-C motif chemokine | CXCL6 | 113 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83303 Genomic DNA Translation: AAC51338.1 U81234 mRNA Translation: AAD00506.1 AK311981 mRNA Translation: BAG34920.1 AC108029 Genomic DNA Translation: AAY40939.1 BC013744 mRNA Translation: AAH13744.1 Y08770 mRNA Translation: CAA70023.1 |
CCDSi | CCDS3560.1 |
PIRi | A54188 |
RefSeqi | NP_002984.1, NM_002993.3 |
Genome annotation databases
Ensembli | ENST00000226317.10; ENSP00000226317.5; ENSG00000124875.10 |
GeneIDi | 6372 |
KEGGi | hsa:6372 |
MANE-Selecti | ENST00000226317.10; ENSP00000226317.5; NM_002993.4; NP_002984.1 |
UCSCi | uc003hhf.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXCL6 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83303 Genomic DNA Translation: AAC51338.1 U81234 mRNA Translation: AAD00506.1 AK311981 mRNA Translation: BAG34920.1 AC108029 Genomic DNA Translation: AAY40939.1 BC013744 mRNA Translation: AAH13744.1 Y08770 mRNA Translation: CAA70023.1 |
CCDSi | CCDS3560.1 |
PIRi | A54188 |
RefSeqi | NP_002984.1, NM_002993.3 |
3D structure databases
AlphaFoldDBi | P80162 |
SMRi | P80162 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112274, 34 interactors |
IntActi | P80162, 12 interactors |
MINTi | P80162 |
STRINGi | 9606.ENSP00000226317 |
PTM databases
iPTMneti | P80162 |
PhosphoSitePlusi | P80162 |
Genetic variation databases
BioMutai | CXCL6 |
DMDMi | 2851486 |
Proteomic databases
MassIVEi | P80162 |
MaxQBi | P80162 |
PaxDbi | P80162 |
PeptideAtlasi | P80162 |
PRIDEi | P80162 |
ProteomicsDBi | 57668 |
Protocols and materials databases
Antibodypediai | 13323, 284 antibodies from 22 providers |
DNASUi | 6372 |
Genome annotation databases
Ensembli | ENST00000226317.10; ENSP00000226317.5; ENSG00000124875.10 |
GeneIDi | 6372 |
KEGGi | hsa:6372 |
MANE-Selecti | ENST00000226317.10; ENSP00000226317.5; NM_002993.4; NP_002984.1 |
UCSCi | uc003hhf.4, human |
Organism-specific databases
CTDi | 6372 |
DisGeNETi | 6372 |
GeneCardsi | CXCL6 |
HGNCi | HGNC:10643, CXCL6 |
HPAi | ENSG00000124875, Group enriched (gallbladder, lymphoid tissue, urinary bladder) |
MIMi | 138965, gene |
neXtProti | NX_P80162 |
OpenTargetsi | ENSG00000124875 |
PharmGKBi | PA35574 |
VEuPathDBi | HostDB:ENSG00000124875 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000162749 |
InParanoidi | P80162 |
OMAi | KELRCTC |
OrthoDBi | 1556509at2759 |
PhylomeDBi | P80162 |
TreeFami | TF333433 |
Enzyme and pathway databases
PathwayCommonsi | P80162 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P80162 |
Miscellaneous databases
BioGRID-ORCSi | 6372, 7 hits in 1057 CRISPR screens |
ChiTaRSi | CXCL6, human |
GenomeRNAii | 6372 |
Pharosi | P80162, Tbio |
PROi | PR:P80162 |
RNActi | P80162, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124875, Expressed in smooth muscle tissue and 133 other tissues |
ExpressionAtlasi | P80162, baseline and differential |
Genevisiblei | P80162, HS |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCL6_HUMAN | |
Accessioni | P80162Primary (citable) accession number: P80162 Secondary accession number(s): B2R4X3, Q4W5D4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families