CXCL6

Functionⁱ

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).4 Publications

GO - Molecular functionⁱ

chemokine activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143
heparin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 9164944
cellular response to lipopolysaccharide
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 9164944
defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukocyte homeostasis Source: Ensembl
neutrophil activation
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143
neutrophil chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143
regulation of chemokine production Source: Ensembl
regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9164944

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Cytokine, Heparin-binding
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 6 Alternative name(s): Chemokine alpha 3 Short name: CKA-3 Granulocyte chemotactic protein 2 Short name: GCP-2 Small-inducible cytokine B6 Cleaved into the following 3 chains: Small-inducible cytokine B6, N-processed variant 1 Small-inducible cytokine B6, N-processed variant 2 Small-inducible cytokine B6, N-processed variant 3
Gene namesⁱ	Name:CXCL6 Synonyms:GCP2, SCYB6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124875.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10643 CXCL6
MIMⁱ	138965 gene
neXtProtⁱ	NX_P80162

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6372
Open Targets More...OpenTargetsⁱ	ENSG00000124875
PharmGKBⁱ	PA35574

Polymorphism and mutation databases

BioMutaⁱ	CXCL6
DMDMⁱ	2851486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 37	2 PublicationsAdd BLAST	37
ChainⁱPRO_0000005084	38 – 114	C-X-C motif chemokine 6Add BLAST	77
ChainⁱPRO_0000005085	40 – 114	Small-inducible cytokine B6, N-processed variant 1Add BLAST	75
ChainⁱPRO_0000005086	43 – 114	Small-inducible cytokine B6, N-processed variant 2Add BLAST	72
ChainⁱPRO_0000005087	46 – 114	Small-inducible cytokine B6, N-processed variant 3Add BLAST	69

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	49 ↔ 75	By similarity
Disulfide bondⁱ	51 ↔ 91	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P80162
PaxDbⁱ	P80162
PeptideAtlas More...PeptideAtlasⁱ	P80162
PRIDEⁱ	P80162
ProteomicsDBⁱ	57668

PTM databases

iPTMnetⁱ	P80162
PhosphoSitePlusⁱ	P80162

Miscellaneous databases

PMAP-CutDBⁱ	P80162

PMAP-CutDBⁱ

P80162

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124875 Expressed in 117 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL6
ExpressionAtlasⁱ	P80162 baseline and differential
Genevisibleⁱ	P80162 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCL5	P13501	2	EBI-9214033,EBI-2848366
CXCL12	P48061	2	EBI-9214033,EBI-3913254
PF4	P02776	2	EBI-9214033,EBI-2565740

GO - Molecular functionⁱ

chemokine activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8399143

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112274, 1 interactor
IntActⁱ	P80162, 12 interactors
Molecular INTeraction database More...MINTⁱ	P80162
STRINGⁱ	9606.ENSP00000226317

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P80162
SMRⁱ	P80162
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4TR Eukaryota ENOG41117DC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P80162
KEGG Orthology (KO) More...KOⁱ	K05506
OMAⁱ	TELRCTC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G132U
PhylomeDBⁱ	P80162
TreeFamⁱ	TF333433

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P80162-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT 
        60         70         80         90        100
CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK 
       110 
KVIQKILDSG NKKN

Length:114

Mass (Da):11,897

Last modified:July 15, 1998 - v4

Checksum:ⁱ5A58B38C17F25178

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RF92	D6RF92_HUMAN		C-X-C motif chemokine C-X-C motif chemokine	CXCL6	113	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83303 Genomic DNA Translation: AAC51338.1 U81234 mRNA Translation: AAD00506.1 AK311981 mRNA Translation: BAG34920.1 AC108029 Genomic DNA Translation: AAY40939.1 BC013744 mRNA Translation: AAH13744.1 Y08770 mRNA Translation: CAA70023.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3560.1
PIRⁱ	A54188
NCBI Reference Sequences More...RefSeqⁱ	NP_002984.1, NM_002993.3
UniGeneⁱ	Hs.164021

Genome annotation databases

Ensemblⁱ	ENST00000226317; ENSP00000226317; ENSG00000124875
GeneIDⁱ	6372
KEGGⁱ	hsa:6372
UCSC genome browser More...UCSCⁱ	uc003hhf.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P80162	C-X-C motif chemokine		PANTR		114	UniRef90_P80162
C-X-C motif chemokine		PONAB		114
C-X-C motif chemokine		COLAP		114
C-X-C motif chemokine		PANPA		114
C-X-C motif chemokine		NOMLE		114
+3

Protein	Similar proteins		Species	Score	Length	Source
P80162	C-X-C motif chemokine 5	)	HUMAN		114	UniRef50_P42830
C-X-C motif chemokine		NOMLE		114
C-X-C motif chemokine		GORGO		114
C-X-C motif chemokine		PANPA		114
C-X-C motif chemokine		PANTR		114
+49

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL6 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83303 Genomic DNA Translation: AAC51338.1 U81234 mRNA Translation: AAD00506.1 AK311981 mRNA Translation: BAG34920.1 AC108029 Genomic DNA Translation: AAY40939.1 BC013744 mRNA Translation: AAH13744.1 Y08770 mRNA Translation: CAA70023.1
CCDSⁱ	CCDS3560.1
PIRⁱ	A54188
RefSeqⁱ	NP_002984.1, NM_002993.3
UniGeneⁱ	Hs.164021

3D structure databases

ProteinModelPortalⁱ	P80162
SMRⁱ	P80162
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112274, 1 interactor
IntActⁱ	P80162, 12 interactors
MINTⁱ	P80162
STRINGⁱ	9606.ENSP00000226317

PTM databases

iPTMnetⁱ	P80162
PhosphoSitePlusⁱ	P80162

Polymorphism and mutation databases

BioMutaⁱ	CXCL6
DMDMⁱ	2851486

Proteomic databases

MaxQBⁱ	P80162
PaxDbⁱ	P80162
PeptideAtlasⁱ	P80162
PRIDEⁱ	P80162
ProteomicsDBⁱ	57668

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6372
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000226317; ENSP00000226317; ENSG00000124875
GeneIDⁱ	6372
KEGGⁱ	hsa:6372
UCSCⁱ	uc003hhf.4 human

Organism-specific databases

CTDⁱ	6372
DisGeNETⁱ	6372
EuPathDBⁱ	HostDB:ENSG00000124875.9
GeneCardsⁱ	CXCL6
HGNCⁱ	HGNC:10643 CXCL6
MIMⁱ	138965 gene
neXtProtⁱ	NX_P80162
OpenTargetsⁱ	ENSG00000124875
PharmGKBⁱ	PA35574
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4TR Eukaryota ENOG41117DC LUCA
GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P80162
KOⁱ	K05506
OMAⁱ	TELRCTC
OrthoDBⁱ	EOG091G132U
PhylomeDBⁱ	P80162
TreeFamⁱ	TF333433

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GenomeRNAiⁱ	6372
PMAP-CutDBⁱ	P80162
Protein Ontology More...PROⁱ	PR:P80162
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124875 Expressed in 117 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL6
ExpressionAtlasⁱ	P80162 baseline and differential
Genevisibleⁱ	P80162 HS

Family and domain databases

CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCL6_HUMAN
Accessionⁱ	P80162Primary (citable) accession number: P80162 Secondary accession number(s): B2R4X3, Q4W5D4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	July 15, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P80162 (CXCL6_HUMAN)

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C-X-C motif chemokine 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ