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Protein

Long neurotoxin 4

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Long neurotoxin 4
Alternative name(s):
Alpha-neurotoxin
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000935591 – 72Long neurotoxin 4Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 22By similarity
Disulfide bondi15 ↔ 43By similarity
Disulfide bondi28 ↔ 32By similarity
Disulfide bondi47 ↔ 58By similarity
Disulfide bondi59 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiP80156

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP80156
SMRiP80156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P80156-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TKCYKTGDRI ISEACPPGQD LCYMKTWCDV FCGTRGRVIE LGCTATCPTV
60 70
KPHEQITCCS TDNCNPHPKM KQ
Length:72
Mass (Da):8,014
Last modified:December 1, 1992 - v1
Checksum:iB07C011DACD21195
GO

Sequence databases

PIRiJC1474

Similar proteinsi

Entry informationi

Entry namei3L24_OPHHA
AccessioniPrimary (citable) accession number: P80156
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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