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Protein

4-aminobutyrate aminotransferase, mitochondrial

Gene

ABAT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphate2 Publications, [2Fe-2S] cluster1 PublicationNote: Binds 1 [2Fe-2S] cluster per homodimer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi163Iron-sulfur (2Fe-2S); shared with dimeric partner1 Publication1
Metal bindingi166Iron-sulfur (2Fe-2S); shared with dimeric partner1 Publication1
Binding sitei220Substrate1 Publication1 Publication1
Binding sitei381Pyridoxal phosphate; shared with dimeric partner2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processNeurotransmitter degradation
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.19 6170
ReactomeiR-SSC-916853 Degradation of GABA
SABIO-RKiP80147

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase, mitochondrial (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Short name:
GABA-T
L-AIBAT
Gene namesi
Name:ABAT
Synonyms:GABAT
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28Mitochondrion1 PublicationAdd BLAST28
ChainiPRO_000000125129 – 5004-aminobutyrate aminotransferase, mitochondrialAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231N6-succinyllysineBy similarity1
Modified residuei252N6-acetyllysine; alternateBy similarity1
Modified residuei252N6-succinyllysine; alternateBy similarity1
Modified residuei279N6-acetyllysineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Disulfide bondi321InterchainBy similarity
Modified residuei357N6-(pyridoxal phosphate)lysine1 Publication1
Modified residuei413N6-acetyllysine; alternateBy similarity1
Modified residuei413N6-succinyllysine; alternateBy similarity1
Modified residuei452N6-acetyllysineBy similarity1
Modified residuei470N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP80147
PeptideAtlasiP80147
PRIDEiP80147

Expressioni

Gene expression databases

ExpressionAtlasiP80147 baseline and differential
GenevisibleiP80147 SS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1149627, 1 interactor
STRINGi9823.ENSSSCP00000008445

Chemistry databases

BindingDBiP80147

Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80147
SMRiP80147
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80147

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Pyridoxal phosphate binding1 Publication2

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1405 Eukaryota
COG0160 LUCA
GeneTreeiENSGT00550000074885
HOGENOMiHOG000020208
HOVERGENiHBG000634
InParanoidiP80147
KOiK13524
OrthoDBiEOG091G08T5

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P80147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVLLTRRL ACSFRHNHRL LVPGWRHISQ AAAKVDVEFD YDGPLMKTEV
60 70 80 90 100
PGPRSRELMK QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI
110 120 130 140 150
SSIPIGYSHP ALVKLVQQPQ NVSTFINRPA LGILPPENFV EKLRESLLSV
160 170 180 190 200
APKGMSQLIT MACGSCSNEN AFKTIFMWYR SKERGQSAFS KEELETCMIN
210 220 230 240 250
QAPGCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS FDWPIAPFPR
260 270 280 290 300
LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG
310 320 330 340 350
DNHASDDFFR KLRDISRKHG CAFLVDEVQT GGGSTGKFWA HEHWGLDDPA
360 370 380 390 400
DVMTFSKKMM TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK
410 420 430 440 450
REDLLSNAAH AGKVLLTGLL DLQARYPQFI SRVRGRGTFC SFDTPDESIR
460 470 480 490 500
NKLISIARNK GVMLGGCGDK SIRFRPTLVF RDHHAHLFLN IFSDILADFK
Length:500
Mass (Da):56,620
Last modified:December 1, 1992 - v2
Checksum:iBFD0B80846CEF5B7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286ZMM3A0A286ZMM3_PIG
4-aminobutyrate aminotransferase, m...
ABAT
444Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454I → N in AAA96981 (PubMed:1559966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84802 mRNA Translation: AAA96981.1
RefSeqiNP_999428.1, NM_214263.1
UniGeneiSsc.16251

Genome annotation databases

EnsembliENSSSCT00000008668; ENSSSCP00000008445; ENSSSCG00000007909
ENSSSCT00000039445; ENSSSCP00000045366; ENSSSCG00000007909
ENSSSCT00000048101; ENSSSCP00000032632; ENSSSCG00000007909
ENSSSCT00000064948; ENSSSCP00000035621; ENSSSCG00000007909
GeneIDi397500
KEGGissc:397500

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84802 mRNA Translation: AAA96981.1
RefSeqiNP_999428.1, NM_214263.1
UniGeneiSsc.16251

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OHVX-ray2.30A/B/C/D29-500[»]
1OHWX-ray2.30A/B/C/D29-500[»]
1OHYX-ray2.80A/B/C/D29-500[»]
4Y0DX-ray2.19A/B/C/D39-500[»]
4Y0HX-ray1.63A/B/C/D39-500[»]
4Y0IX-ray1.66A/B/C/D39-499[»]
4ZSWX-ray1.70A/B/C/D39-499[»]
4ZSYX-ray1.70A/B/C/D39-499[»]
6B6GX-ray1.95A/B/C/D39-500[»]
ProteinModelPortaliP80147
SMRiP80147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1149627, 1 interactor
STRINGi9823.ENSSSCP00000008445

Chemistry databases

BindingDBiP80147
ChEMBLiCHEMBL2266

Proteomic databases

PaxDbiP80147
PeptideAtlasiP80147
PRIDEiP80147

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008668; ENSSSCP00000008445; ENSSSCG00000007909
ENSSSCT00000039445; ENSSSCP00000045366; ENSSSCG00000007909
ENSSSCT00000048101; ENSSSCP00000032632; ENSSSCG00000007909
ENSSSCT00000064948; ENSSSCP00000035621; ENSSSCG00000007909
GeneIDi397500
KEGGissc:397500

Organism-specific databases

CTDi18

Phylogenomic databases

eggNOGiKOG1405 Eukaryota
COG0160 LUCA
GeneTreeiENSGT00550000074885
HOGENOMiHOG000020208
HOVERGENiHBG000634
InParanoidiP80147
KOiK13524
OrthoDBiEOG091G08T5

Enzyme and pathway databases

BRENDAi2.6.1.19 6170
ReactomeiR-SSC-916853 Degradation of GABA
SABIO-RKiP80147

Miscellaneous databases

ChiTaRSiABAT pig
EvolutionaryTraceiP80147
PROiPR:P80147

Gene expression databases

ExpressionAtlasiP80147 baseline and differential
GenevisibleiP80147 SS

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGABT_PIG
AccessioniPrimary (citable) accession number: P80147
Secondary accession number(s): P27820
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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