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Protein

C-C motif chemokine 7

Gene

CCL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • CCR2 chemokine receptor binding Source: Ensembl
  • chemokine activity Source: UniProtKB
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

SIGNORiP80098

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
NC28
Small-inducible cytokine A7
Gene namesi
Name:CCL7
Synonyms:MCP3, SCYA6, SCYA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108688.11
HGNCiHGNC:10634 CCL7
MIMi158106 gene
neXtProtiNX_P80098

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6354
OpenTargetsiENSG00000108688
PharmGKBiPA35566

Chemistry databases

ChEMBLiCHEMBL3217391

Polymorphism and mutation databases

DMDMi1170890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000518324 – 99C-C motif chemokine 7Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid1 Publication1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi34 ↔ 59
Disulfide bondi35 ↔ 75

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP80098
PeptideAtlasiP80098
PRIDEiP80098
ProteomicsDBi57665

Miscellaneous databases

PMAP-CutDBiP80098

Expressioni

Gene expression databases

BgeeiENSG00000108688 Expressed in 90 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CCL7
ExpressionAtlasiP80098 baseline and differential
GenevisibleiP80098 HS

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112257, 8 interactors
DIPiDIP-5847N
IntActiP80098, 8 interactors
STRINGi9606.ENSP00000367832

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP80098
SMRiP80098
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80098

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP80098
KOiK05509
OMAiTTCCYRF
OrthoDBiEOG091G14KV
PhylomeDBiP80098
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P80098-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES
60 70 80 90
YRRTTSSHCP REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL
Length:99
Mass (Da):11,200
Last modified:November 1, 1995 - v3
Checksum:i96048B371C25D00E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MVH1A8MVH1_HUMAN
C-C motif chemokine 7
CCL7
81Annotation score:
A8MX17A8MX17_HUMAN
C-C motif chemokine 7
CCL7
47Annotation score:

Sequence cautioni

The sequence CAA50405 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA50406 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51055 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → K AA sequence (PubMed:1613466).Curated1
Sequence conflicti68 – 70Missing AA sequence (PubMed:1613466).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA Translation: CAA51055.1 Different initiation.
X72309 Genomic DNA No translation available.
X71087 mRNA Translation: CAA50407.1
X71087 mRNA Translation: CAA50406.1 Different initiation.
X71087 mRNA Translation: CAA50405.1 Different initiation.
BC092436 mRNA Translation: AAH92436.1
BC112258 mRNA Translation: AAI12259.1
BC112260 mRNA Translation: AAI12261.1
AF043338 mRNA Translation: AAC03538.1
CCDSiCCDS11278.1
RefSeqiNP_006264.2, NM_006273.3
UniGeneiHs.251526

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688
GeneIDi6354
KEGGihsa:6354
UCSCiuc002hhz.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72308 mRNA Translation: CAA51055.1 Different initiation.
X72309 Genomic DNA No translation available.
X71087 mRNA Translation: CAA50407.1
X71087 mRNA Translation: CAA50406.1 Different initiation.
X71087 mRNA Translation: CAA50405.1 Different initiation.
BC092436 mRNA Translation: AAH92436.1
BC112258 mRNA Translation: AAI12259.1
BC112260 mRNA Translation: AAI12261.1
AF043338 mRNA Translation: AAC03538.1
CCDSiCCDS11278.1
RefSeqiNP_006264.2, NM_006273.3
UniGeneiHs.251526

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BO0NMR-A24-99[»]
1NCVNMR-A/B24-99[»]
4ZKCX-ray3.15B24-99[»]
ProteinModelPortaliP80098
SMRiP80098
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112257, 8 interactors
DIPiDIP-5847N
IntActiP80098, 8 interactors
STRINGi9606.ENSP00000367832

Chemistry databases

ChEMBLiCHEMBL3217391

Polymorphism and mutation databases

DMDMi1170890

Proteomic databases

PaxDbiP80098
PeptideAtlasiP80098
PRIDEiP80098
ProteomicsDBi57665

Protocols and materials databases

DNASUi6354
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378569; ENSP00000367832; ENSG00000108688
GeneIDi6354
KEGGihsa:6354
UCSCiuc002hhz.5 human

Organism-specific databases

CTDi6354
DisGeNETi6354
EuPathDBiHostDB:ENSG00000108688.11
GeneCardsiCCL7
HGNCiHGNC:10634 CCL7
MIMi158106 gene
neXtProtiNX_P80098
OpenTargetsiENSG00000108688
PharmGKBiPA35566
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP80098
KOiK05509
OMAiTTCCYRF
OrthoDBiEOG091G14KV
PhylomeDBiP80098
TreeFamiTF334888

Enzyme and pathway databases

SIGNORiP80098

Miscellaneous databases

EvolutionaryTraceiP80098
GeneWikiiCCL7
GenomeRNAii6354
PMAP-CutDBiP80098
PROiPR:P80098
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108688 Expressed in 90 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CCL7
ExpressionAtlasiP80098 baseline and differential
GenevisibleiP80098 HS

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL7_HUMAN
AccessioniPrimary (citable) accession number: P80098
Secondary accession number(s): Q569J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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