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UniProtKB - P80060 (LCM_LOCMI)
Protein
Protease inhibitors
Gene
N/A
Organism
Locusta migratoria (Migratory locust)
Status
Functioni
Both LCMI I and II are inhibitors of chymotrypsin and elastase (in vitro). They both inhibit the prophenol oxidase activation cascade.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 48 – 49 | Reactive bond | 2 | |
Sitei | 86 – 87 | Reactive bond | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Protein family/group databases
MEROPSi | I19.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Protease inhibitorsCleaved into the following 2 chains: Alternative name(s): PARS intercerebralis major peptide D2 Short name: PMP-D2 Alternative name(s): PARS intercerebralis major peptide C Short name: PMP-C |
Organismi | Locusta migratoria (Migratory locust) |
Taxonomic identifieri | 7004 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Polyneoptera › Orthoptera › Caelifera › Acrididea › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 2 PublicationsAdd BLAST | 19 | |
PeptideiPRO_0000026708 | 20 – 54 | Protease inhibitor LCMI-IAdd BLAST | 35 | |
PeptideiPRO_0000026709 | 57 – 92 | Protease inhibitor LCMI-IIAdd BLAST | 36 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 23 ↔ 38 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 33 ↔ 51 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 36 ↔ 46 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 60 ↔ 75 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 65 | O-linked (Fuc) threonine1 Publication | 1 | |
Disulfide bondi | 70 ↔ 89 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 73 ↔ 84 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinPTM databases
iPTMneti | P80060 |
Expressioni
Tissue specificityi
Brain and fat body.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P80060 |
SMRi | P80060 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P80060 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 54 | Pacifastin 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 57 – 92 | Pacifastin 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalFamily and domain databases
InterProi | View protein in InterPro IPR008037, Pacifastin_dom IPR036201, Pacifastin_dom_sf IPR016307, Prtase-inh_pacifastin |
Pfami | View protein in Pfam PF05375, Pacifastin_I, 2 hits |
PIRSFi | PIRSF001625, Prot_inhib_pacifastin, 1 hit |
SUPFAMi | SSF57283, SSF57283, 2 hits |
PROSITEi | View protein in PROSITE PS51446, PACIFASTIN, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P80060-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFALALCAA VLLVVLVQAE EKCTPGQVKQ QDCNTCTCTP TGVWGCTRKG
60 70 80 90
CQPAKREISC EPGKTFKDKC NTCRCGADGK SAACTLKACP NQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22805 mRNA Translation: CAA80462.1 |
PIRi | S36658 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22805 mRNA Translation: CAA80462.1 |
PIRi | S36658 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GL0 | X-ray | 3.00 | I | 20-54 | [»] | |
1GL1 | X-ray | 2.10 | I/J/K | 57-92 | [»] | |
1PMC | NMR | - | A | 57-92 | [»] | |
AlphaFoldDBi | P80060 | |||||
SMRi | P80060 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P80060 |
Protein family/group databases
MEROPSi | I19.001 |
PTM databases
iPTMneti | P80060 |
Miscellaneous databases
EvolutionaryTracei | P80060 |
Family and domain databases
InterProi | View protein in InterPro IPR008037, Pacifastin_dom IPR036201, Pacifastin_dom_sf IPR016307, Prtase-inh_pacifastin |
Pfami | View protein in Pfam PF05375, Pacifastin_I, 2 hits |
PIRSFi | PIRSF001625, Prot_inhib_pacifastin, 1 hit |
SUPFAMi | SSF57283, SSF57283, 2 hits |
PROSITEi | View protein in PROSITE PS51446, PACIFASTIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LCM_LOCMI | |
Accessioni | P80060Primary (citable) accession number: P80060 Secondary accession number(s): P80058 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families