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Protein

Glutamate dehydrogenase 2

Gene

gdhA-2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi1.4.1.3 6163
SABIO-RKiP80053

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase 2 (EC:1.4.1.3)
Short name:
GDH-2
Gene namesi
Name:gdhA-2
Synonyms:gdhA
Ordered Locus Names:SSO1907
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001827612 – 420Glutamate dehydrogenase 2Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylmethionine1 Publication1
Modified residuei254N6-methyllysine1 Publication1
Modified residuei260N6-methyllysine1 Publication1
Modified residuei372N6-methyllysine1 Publication1
Modified residuei391N6-methyllysine1 Publication1
Modified residuei392N6-methyllysine1 Publication1

Post-translational modificationi

Methylation of lysine residues may play a role in the thermal stability of this enzyme.

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PRIDEiP80053

PTM databases

iPTMnetiP80053

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRINGi273057.SSO1907

Structurei

3D structure databases

ProteinModelPortaliP80053
SMRiP80053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01352 Archaea
COG0334 LUCA
HOGENOMiHOG000243801
InParanoidiP80053
KOiK00261
OMAiWEEDRVN
OrthoDBiPOG093Z075Z

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEEVLSSSL YTQQVKKLYK VGELLGLDNE TLETLSQPER IIQVKIQIRG
60 70 80 90 100
SDGKLKTFMG WRSQHNSALG PYKGGVRYHP NVTQDEVEAL SMIMTWKNSL
110 120 130 140 150
LLLPYGGGKG GVRVDPKKLT REELEQLSRK YIQAIYKYLG SELDIPAPDV
160 170 180 190 200
NTDSQTMAWF LDEYIKITGK VDFAVFTGKP VELGGIGVRL YSTGLGVATI
210 220 230 240 250
AKEAANKFIG GVEEARVIIQ GFGNVGYYAG KFLSEMGAKI VGVSDSKGGV
260 270 280 290 300
INEKGIDVGK AIEIKEKTGS VINYPEGRKV TNEELLISDC DILIPAALEN
310 320 330 340 350
VINKFNAPKV KAKLIVEGAN GPLTADADEI MRQRGIAVVP DILANAGGVV
360 370 380 390 400
GSYVEWANNK MGEIISDEEA KKLIVDRMNN AFNTLYDYHQ KKLEDHDLRT
410 420
AAMALAVDRV VRAMKARGIL
Length:420
Mass (Da):46,031
Last modified:March 18, 2008 - v3
Checksum:iD9283C66D305EED5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203E → EE AA sequence (PubMed:1730244).Curated1
Sequence conflicti392K → KK AA sequence (PubMed:1730244).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK42099.1
PIRiD90355
S20286

Genome annotation databases

EnsemblBacteriaiAAK42099; AAK42099; SSO1907
KEGGisso:SSO1907
PATRICifig|273057.12.peg.1968

Similar proteinsi

Entry informationi

Entry nameiDHE2_SULSO
AccessioniPrimary (citable) accession number: P80053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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