UniProtKB - P80021 (ATPA_PIG)
ATP synthase subunit alpha, mitochondrial
ATP5F1A
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 413 | Required for activityBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 213 – 220 | ATPBy similarity | 8 | |
Nucleotide bindingi | 473 – 475 | ATPBy similarity | 3 |
GO - Molecular functioni
- ADP binding Source: GO_Central
- ATP binding Source: GO_Central
- proton-transporting ATP synthase activity, rotational mechanism Source: GO_Central
GO - Biological processi
- ATP synthesis coupled proton transport Source: GO_Central
Keywordsi
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit alpha, mitochondrialCuratedAlternative name(s): ATP synthase F1 subunit alphaBy similarity ATP synthase subunit alpha heart isoform, mitochondrial ATP synthase subunit alpha liver isoform, mitochondrial |
Gene namesi | Name:ATP5F1ABy similarity Synonyms:ATP5A1, ATP5A2 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity
Mitochondrion
- Mitochondrion 1 Publication
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Note: Colocalizes with HRG on the cell surface of T-cells.By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- proton-transporting ATP synthase complex, catalytic core F(1) Source: GO_Central
Keywords - Cellular componenti
Cell membrane, CF(1), Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 43 | MitochondrionBy similarityAdd BLAST | 43 | |
ChainiPRO_0000144412 | 44 – 553 | ATP synthase subunit alpha, mitochondrialAdd BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 65 | PhosphoserineBy similarity | 1 | |
Modified residuei | 76 | Phosphoserine; alternateBy similarity | 1 | |
Glycosylationi | 76 | O-linked (GlcNAc) serine; alternateBy similarity | 1 | |
Modified residuei | 106 | PhosphoserineBy similarity | 1 | |
Modified residuei | 123 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 126 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 132 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 134 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 161 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 161 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 167 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 184 | PhosphoserineBy similarity | 1 | |
Modified residuei | 204 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 230 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 230 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 239 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 239 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 240 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 261 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 261 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 305 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 305 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 427 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 427 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 434 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 498 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 498 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 506 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 506 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 531 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 531 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 539 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 539 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 541 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Methylation, PhosphoproteinProteomic databases
PaxDbi | P80021 |
PeptideAtlasi | P80021 |
PRIDEi | P80021 |
Expressioni
Tissue specificityi
Gene expression databases
ExpressionAtlasi | P80021, baseline and differential |
Genevisiblei | P80021, SS |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1 (PubMed:1714390). CF0 has three main subunits: a, b and c (By similarity).
Interacts with ATPAF2.
Interacts with HRG; the interaction occurs on the surface of T-cells and alters the cell morphology when associated with concanavalin (in vitro).
Interacts with PLG (angiostatin peptide); the interaction inhibits most of the angiogenic properties of angiostatin (By similarity).
Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).
Interacts with BLOC1S1 (By similarity).
Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F1F0 ATP synthase and enhances neurons metabolic efficiency (By similarity).
Interacts with CLN5 and PPT1 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
IntActi | P80021, 1 interactor |
STRINGi | 9823.ENSSSCP00000004854 |
Structurei
Secondary structure
3D structure databases
BMRBi | P80021 |
SMRi | P80021 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1353, Eukaryota |
GeneTreei | ENSGT00550000074846 |
HOGENOMi | CLU_010091_2_1_1 |
OrthoDBi | 470054at2759 |
Family and domain databases
CDDi | cd01132, F1_ATPase_alpha, 1 hit |
Gene3Di | 1.20.150.20, 1 hit 2.40.30.20, 1 hit |
HAMAPi | MF_01346, ATP_synth_alpha_bact, 1 hit |
InterProi | View protein in InterPro IPR023366, ATP_synth_asu-like_sf IPR000793, ATP_synth_asu_C IPR038376, ATP_synth_asu_C_sf IPR033732, ATP_synth_F1_a IPR005294, ATP_synth_F1_asu IPR020003, ATPase_a/bsu_AS IPR004100, ATPase_F1/V1/A1_a/bsu_N IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF00306, ATP-synt_ab_C, 1 hit PF02874, ATP-synt_ab_N, 1 hit |
PIRSFi | PIRSF039088, F_ATPase_subunit_alpha, 1 hit |
SUPFAMi | SSF50615, SSF50615, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00962, atpA, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLSVRVAAAV ARALPRRAGL VSKNALGSSF VAARNLHASN TRLQKTGTAE
60 70 80 90 100
VSSILEERIL GADTSVDLEE TGRVLSIGDG IARVHGLRNV QAEEMVEFSS
110 120 130 140 150
GLKGMSLNLE PDNVGVVVFG NDKLIKEGDI VKRTGAIVDV PVGEELLGRV
160 170 180 190 200
VDALGNAIDG KGPIGSKTRR RVGLKAPGII PRISVREPMQ TGIKAVDSLV
210 220 230 240 250
PIGRGQRELI IGDRQTGKTS IAIDTIINQK RFNDGTDEKK KLYCIYVAIG
260 270 280 290 300
QKRSTVAQLV KRLTDADAMK YTIVVSATAS DAAPLQYLAP YSGCSMGEYF
310 320 330 340 350
RDNGKHALII YDDLSKQAVA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE
360 370 380 390 400
RAAKMNDAFG GGSLTALPVI ETQAGDVSAY IPTNVISITD GQIFLETELF
410 420 430 440 450
YKGIRPAINV GLSVSRVGSA AQTRAMKQVA GTMKLELAQY REVAAFAQFG
460 470 480 490 500
SDLDAATQQL LSRGVRLTEL LKQGQYAPMA IEEQVAVIYA GVRGYLDKLE
510 520 530 540 550
PSKITKFENA FLSHVISQHQ ALLGKIRADG KISEETDAKL KEIVTNFLAG
FEA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1RPT1 | F1RPT1_PIG | ATP synthase subunit alpha | ATP5F1A | 643 | Annotation score: | ||
A0A287BRD5 | A0A287BRD5_PIG | ATP synthase subunit alpha, mitocho... | ATP5F1A | 737 | Annotation score: | ||
A0A5G2QY15 | A0A5G2QY15_PIG | ATP synthase subunit alpha | ATP5F1A | 632 | Annotation score: | ||
F1RPS8 | F1RPS8_PIG | ATP synthase subunit alpha | ATP5F1A | 539 | Annotation score: | ||
A0A287AGU2 | A0A287AGU2_PIG | ATP synthase subunit alpha | ATP5F1A | 550 | Annotation score: | ||
A0A287BBS4 | A0A287BBS4_PIG | ATP synthase subunit alpha | ATP5F1A | 555 | Annotation score: | ||
A0A287A874 | A0A287A874_PIG | ATP synthase subunit alpha, mitocho... | ATP5F1A | 706 | Annotation score: | ||
A0A5G2R5C5 | A0A5G2R5C5_PIG | ATP synthase subunit alpha, mitocho... | ATP5F1A | 665 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | S → A AA sequence (PubMed:1714390).Curated | 1 | |
Sequence conflicti | 144 – 145 | EE → KD in CAA23135 (PubMed:8672129).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU650784 mRNA Translation: ACD02421.1 F14580 mRNA Translation: CAA23135.1 |
RefSeqi | NP_001172071.1, NM_001185142.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU650784 mRNA Translation: ACD02421.1 F14580 mRNA Translation: CAA23135.1 |
RefSeqi | NP_001172071.1, NM_001185142.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6J5I | electron microscopy | 3.34 | A/B/C | 45-553 | [»] | |
6J5J | electron microscopy | 3.45 | A/B/C | 45-553 | [»] | |
6J5K | electron microscopy | 6.20 | A/AA/AB/AC/B/BA/BB/BC/C/CA/CB/CC | 45-553 | [»] | |
BMRBi | P80021 | |||||
SMRi | P80021 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P80021, 1 interactor |
STRINGi | 9823.ENSSSCP00000004854 |
Proteomic databases
PaxDbi | P80021 |
PeptideAtlasi | P80021 |
PRIDEi | P80021 |
Genome annotation databases
Organism-specific databases
CTDi | 498 |
Phylogenomic databases
eggNOGi | KOG1353, Eukaryota |
GeneTreei | ENSGT00550000074846 |
HOGENOMi | CLU_010091_2_1_1 |
OrthoDBi | 470054at2759 |
Gene expression databases
ExpressionAtlasi | P80021, baseline and differential |
Genevisiblei | P80021, SS |
Family and domain databases
CDDi | cd01132, F1_ATPase_alpha, 1 hit |
Gene3Di | 1.20.150.20, 1 hit 2.40.30.20, 1 hit |
HAMAPi | MF_01346, ATP_synth_alpha_bact, 1 hit |
InterProi | View protein in InterPro IPR023366, ATP_synth_asu-like_sf IPR000793, ATP_synth_asu_C IPR038376, ATP_synth_asu_C_sf IPR033732, ATP_synth_F1_a IPR005294, ATP_synth_F1_asu IPR020003, ATPase_a/bsu_AS IPR004100, ATPase_F1/V1/A1_a/bsu_N IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF00306, ATP-synt_ab_C, 1 hit PF02874, ATP-synt_ab_N, 1 hit |
PIRSFi | PIRSF039088, F_ATPase_subunit_alpha, 1 hit |
SUPFAMi | SSF50615, SSF50615, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00962, atpA, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPA_PIG | |
Accessioni | P80021Primary (citable) accession number: P80021 Secondary accession number(s): B2ZF46, Q29596 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 13, 2013 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families