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Protein

Alcohol dehydrogenase class-3

Gene
N/A
Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.By similarity

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Sitei117Important for FDH activity and activation by fatty acidsBy similarity1
Metal bindingi176Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeSparus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607661 – 376Alcohol dehydrogenase class-3Add BLAST376

Expressioni

Tissue specificityi

Expressed in the skeletal muscle, heart, gill filaments and liver, with highest levels in the kidney.

Developmental stagei

Found in the eggs and in embryos 4, 8 and 12 hours after fertlization, as well as on all days post-hatching. Level of expression decreases during embryonal development but increases 4-fold from day 1 to day 21 after hatching.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP79896
SMRiP79896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P79896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAGKVIKC KAAVAWEPGK PLSIEEVEVA PPNAHEVRIK LFATGVCHTD
60 70 80 90 100
AYTLSGSDPE GLFPVILGHE GAGTVESVGE GVTKFKPGDT VIPLYVPQCG
110 120 130 140 150
ECKFCKNPKT NLCQKIRITQ GQGLLPDKTS RFTCKGKQVF HFMGTSTFSE
160 170 180 190 200
YTVVADISLA KVNEKAPMDK VCLLGCGIST GYGAALNTAK VEPGSTCAVF
210 220 230 240 250
GLGAVGLAVI MGCKVAGATR IIGIDLNPAK FETAKEFGAT EFVNPKDHSK
260 270 280 290 300
PIQEVLVEMT DGGVDYSFEC IGNVQIMRAA LEACHKGWGE SVIIGVAGAG
310 320 330 340 350
QEISTRPFQL VTGRVWKGTA FGGWKSVESV PKLVEDYMSK KLKVDEFVTH
360 370
TLPFEKINEG FELMHAGKSI RTVLTF
Length:376
Mass (Da):40,215
Last modified:May 1, 1997 - v1
Checksum:i306F27117F3F2313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84791 mRNA Translation: AAB41888.1
PIRiJC4967

Similar proteinsi

Entry informationi

Entry nameiADHX_SPAAU
AccessioniPrimary (citable) accession number: P79896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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