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Protein

Brachyury protein

Gene

T

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 217T-boxPROSITE-ProRule annotationAdd BLAST169

GO - Molecular functioni

  • chaperone binding Source: AgBase
  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brachyury protein
Alternative name(s):
Protein T
Gene namesi
Name:T
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844161 – 433Brachyury proteinAdd BLAST433

Proteomic databases

PaxDbiP79777
PRIDEiP79777

Expressioni

Developmental stagei

First expressed in the posterior epiblast of stage XIII blastoderm, then in the elongating primitive streak, early migrating mesoderm, Hensen node and in the notochord. In later stages, found in tail bud and entire notochord up to stage 26-28.

Inductioni

By FGF-4 and activin.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

  • chaperone binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018703

Structurei

3D structure databases

ProteinModelPortaliP79777
SMRiP79777
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
HOGENOMiHOG000063663
HOVERGENiHBG004599
InParanoidiP79777
PhylomeDBiP79777

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

P79777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPEDAGKA PAYRVDHLLS AVESELQAGS EKGDPTEREL RVALEDGELW
60 70 80 90 100
LRFKELTNEM IVTKNGRRMF PVLKVSVSGL DPNAMYSFLL DFVAADGHRW
110 120 130 140 150
KYVNGEWVPG GKPEPQAPSC VYIHPDSPNF GAHWMKAPVS FSKVKLTNKL
160 170 180 190 200
NGGGQIMLNS LHKYEPRIHI VRVGGPQRMI TSHSFPETQF TAVTAYQNEE
210 220 230 240 250
ITALKIKYNP FAKAFLDAKE RNDHKDMMEE AGDNQQSGYS QLGSWLIPGA
260 270 280 290 300
GALCPPANPH SQFGAPLSLS PAHSCERYSP LRNHRSAPYP NPYTHRNNSP
310 320 330 340 350
TAYTDNSSAC LPMLQSHDNW SSLGVPTHTT MLPMSHSTGT ATSSSQYPNL
360 370 380 390 400
WSVSNSTITP APQSSGMSNG LSSQFLRGSP VHYTALPHPV TATTSTSPLY
410 420 430
DGGAPADLPD SQYDASAHTR LASMWTPITP PSM
Length:433
Mass (Da):47,289
Last modified:May 1, 1997 - v1
Checksum:i8C0C27577E82872F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250A → T (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67086 mRNA Translation: AAC60283.1
U25176 mRNA Translation: AAA67365.1
UniGeneiGga.3772
Gga.52204

Similar proteinsi

Entry informationi

Entry nameiBRAC_CHICK
AccessioniPrimary (citable) accession number: P79777
Secondary accession number(s): Q90654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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