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UniProtKB - P79774 (SNAT_CHICK)
Protein
Serotonin N-acetyltransferase
Gene
AANAT
Organism
Gallus gallus (Chicken)
Status
Functioni
Catalyzes the N-acetylation of serotonin into N-acetylserotonin.
By similarityCatalytic activityi
- EC:2.3.1.87By similarity
: melatonin biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes melatonin from serotonin. This subpathway is part of the pathway melatonin biosynthesis, which is itself part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes melatonin from serotonin, the pathway melatonin biosynthesis and in Aromatic compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 118 | Important for the catalytic mechanism; involved in substrate deprotonationBy similarity | 1 | |
Sitei | 120 | Important for the catalytic mechanism; involved in substrate deprotonationBy similarity | 1 | |
Binding sitei | 122 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 157 | Substrate; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- aralkylamine N-acetyltransferase activity Source: AgBase
- arylamine N-acetyltransferase activity Source: Ensembl
GO - Biological processi
- cellular response to cAMP Source: Ensembl
- cellular response to UV-A Source: AgBase
- circadian rhythm Source: GO_Central
- melatonin biosynthetic process Source: GO_Central
- N-terminal protein amino acid acetylation Source: Ensembl
- response to light stimulus Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Biological rhythms, Melatonin biosynthesis |
Enzyme and pathway databases
BRENDAi | 2.3.1.87, 1306 |
Reactomei | R-GGA-209931, Serotonin and melatonin biosynthesis |
UniPathwayi | UPA00837;UER00815 |
Names & Taxonomyi
Protein namesi | Recommended name: Serotonin N-acetyltransferase (EC:2.3.1.87By similarity)Short name: Serotonin acetylase Alternative name(s): Aralkylamine N-acetyltransferase Short name: AA-NAT |
Gene namesi | Name:AANAT Synonyms:SNAT |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074587 | 1 – 205 | Serotonin N-acetyltransferaseAdd BLAST | 205 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | Phosphothreonine; by PKABy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated; cAMP-dependent phosphorylation on both N-terminal and C-terminal sites regulates AANAT activity through allowing interaction with 14-3-3 proteins and protecting the enzyme against proteasomal degradation.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P79774 |
Expressioni
Tissue specificityi
Expressed in follicular pineal cells and retinal photoreceptors with five times more expression in the pineal gland.1 Publication
Inductioni
Exhibits circadian rhythm pattern in the pineal gland with highest levels at ZT 24. Expression in the retinal photoreceptor cells oscillates in a circadian manner.2 Publications
Gene expression databases
Bgeei | ENSGALG00000001955, Expressed in skeletal muscle tissue and 2 other tissues |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts with YWHAZ; the interaction requires phosphorylation on Thr-29, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-203 site, the other ywhaz monomer with similar effect (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9031.ENSGALP00000003020 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 194 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 11 – 30 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 122 – 124 | Acetyl-CoA bindingBy similarity | 3 | |
Regioni | 130 – 135 | Acetyl-CoA bindingBy similarity | 6 | |
Regioni | 166 – 168 | Acetyl-CoA bindingBy similarity | 3 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4144, Eukaryota |
GeneTreei | ENSGT00390000015579 |
HOGENOMi | CLU_061829_3_1_1 |
InParanoidi | P79774 |
OMAi | HFLNLCP |
OrthoDBi | 1528352at2759 |
PhylomeDBi | P79774 |
TreeFami | TF331622 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
P79774-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVLGAVPFL KPTPLQGPRN SPGRQRRHTL PASEFRCLSP EDAVSVFEIE
60 70 80 90 100
REAFISVSGD CPLHLDEIRH FLTLCPELSL GWFEEGRLVA FIIGSLWDQD
110 120 130 140 150
RLSQAALTLH NPRGTAVHIH VLAVHRTFRQ QGKGSILMWR YLQYLRCLPC
160 170 180 190 200
ARRAVLMCED FLVPFYEKCG FVAVGPCQVT VGTLAFTEMQ HEVRGHAFMR
RNSGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46502 mRNA Translation: AAB40942.1 |
RefSeqi | NP_990489.1, NM_205158.1 XP_015150605.1, XM_015295119.1 |
Genome annotation databases
Ensembli | ENSGALT00000003024; ENSGALP00000003020; ENSGALG00000001955 |
GeneIDi | 396066 |
KEGGi | gga:396066 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46502 mRNA Translation: AAB40942.1 |
RefSeqi | NP_990489.1, NM_205158.1 XP_015150605.1, XM_015295119.1 |
3D structure databases
SMRi | P79774 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000003020 |
Proteomic databases
PaxDbi | P79774 |
Genome annotation databases
Ensembli | ENSGALT00000003024; ENSGALP00000003020; ENSGALG00000001955 |
GeneIDi | 396066 |
KEGGi | gga:396066 |
Organism-specific databases
CTDi | 15 |
Phylogenomic databases
eggNOGi | KOG4144, Eukaryota |
GeneTreei | ENSGT00390000015579 |
HOGENOMi | CLU_061829_3_1_1 |
InParanoidi | P79774 |
OMAi | HFLNLCP |
OrthoDBi | 1528352at2759 |
PhylomeDBi | P79774 |
TreeFami | TF331622 |
Enzyme and pathway databases
UniPathwayi | UPA00837;UER00815 |
BRENDAi | 2.3.1.87, 1306 |
Reactomei | R-GGA-209931, Serotonin and melatonin biosynthesis |
Miscellaneous databases
PROi | PR:P79774 |
Gene expression databases
Bgeei | ENSGALG00000001955, Expressed in skeletal muscle tissue and 2 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAT_CHICK | |
Accessioni | P79774Primary (citable) accession number: P79774 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families