We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P79766 (NDF4_CHICK)
Protein
Neurogenic differentiation factor 4
Gene
NEUROD4
Organism
Gallus gallus (Chicken)
Status
Functioni
Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- amacrine cell differentiation Source: UniProtKB
- neuron development Source: InterPro
- positive regulation of cell differentiation Source: UniProtKB
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic differentiation factor 4Short name: NeuroD4 Alternative name(s): NeuroM |
Gene namesi | Name:NEUROD4 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127395 | 1 – 330 | Neurogenic differentiation factor 4Add BLAST | 330 |
Post-translational modificationi
Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P79766 |
Expressioni
Tissue specificityi
Expressed in both the developing central nervous system and peripheral nervous system.1 Publication
Developmental stagei
Expression in the developing nervous system is transient and restricted to cells lining the ventricular zone that have ceased proliferation but have not yet begun to migrate into the outer layers. In retina, neurom is also transiently expressed in cells as they withdraw from the mitotic cycle, but persists in horizontal and bipolar neurons until full differentiation. In the peripheral nervous system, its expression closely follows cell proliferation.1 Publication
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000040481 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 139 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 79 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 162 – 183 | Leucine-zipperAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 73 – 79 | Nuclear localization signalSequence analysis | 7 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
InParanoidi | P79766 |
OrthoDBi | 1096531at2759 |
PhylomeDBi | P79766 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032651, Neurod4 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF86, PTHR19290:SF86, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
P79766-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKTYTKAKE MAELVGTQGW MDDALSSKDE LKAENGRPGP FGLVAGLNEE
60 70 80 90 100
HDSIEEEEEE EDDGEKPKRR GPKKKKMTKA RLERFRARRV KANARERTRM
110 120 130 140 150
HGLNDALDNL RRVMPCYSKT QKLSKIETLR LARNYIWALS EVLETGQTPE
160 170 180 190 200
GKSFVEMLCK GLSQPTSNLV AGCLQLGPQT LFLEKHEEKT PGCESAISSH
210 220 230 240 250
SFTYQSPGLP SPPYGSMETH LLHLKPPAFK SLVDASFGNP PDCTTPPYEG
260 270 280 290 300
PLTPPLSISG NFSLKQDGSP DLDKPYAFMA HYPSVSLAGA HGHPTHFQNA
310 320 330
VPRYEIPIDM SYESYPHHVA GPQLNAIFNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09597 mRNA Translation: CAA70785.1 |
RefSeqi | NP_990407.1, NM_205076.1 |
Genome annotation databases
GeneIDi | 395959 |
KEGGi | gga:395959 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09597 mRNA Translation: CAA70785.1 |
RefSeqi | NP_990407.1, NM_205076.1 |
3D structure databases
SMRi | P79766 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000040481 |
Proteomic databases
PaxDbi | P79766 |
Genome annotation databases
GeneIDi | 395959 |
KEGGi | gga:395959 |
Organism-specific databases
CTDi | 58158 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
InParanoidi | P79766 |
OrthoDBi | 1096531at2759 |
PhylomeDBi | P79766 |
Miscellaneous databases
PROi | PR:P79766 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032651, Neurod4 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF86, PTHR19290:SF86, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDF4_CHICK | |
Accessioni | P79766Primary (citable) accession number: P79766 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |