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Entry version 116 (12 Aug 2020)
Sequence version 4 (08 Mar 2011)
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Protein

Zona pellucida sperm-binding protein 3

Gene

ZP3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the zona pellucida, which mediates species-specific sperm binding. Directly binds to sperm. Important for egg fertilization.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acrosin binding Source: GO_Central
  • identical protein binding Source: IntAct
  • structural constituent of egg coat Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFertilization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 3
Alternative name(s):
Sperm receptor
Zona pellucida C protein
Zona pellucida glycoprotein 3
Short name:
Zp-3
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZP3
Synonyms:ZPC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 405ExtracellularCuratedAdd BLAST385
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 437CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-152. 1 Publication1
Mutagenesisi90C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-111. 1 Publication1
Mutagenesisi111C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-90. 1
Mutagenesisi142R → A: Impaired homodimerization and abolished secretion of processed zona pellucida sperm-binding protein 3. 1 Publication1
Mutagenesisi152C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-58. 1 Publication1
Mutagenesisi159N → Q: Loss of N-glycosylation. 1 Publication1
Mutagenesisi168T → A: Loss of O-glycosylation. No effect on secretion. Reduces binding to the sperm head by about 80%. 1 Publication1
Mutagenesisi196E → A: No effect on secretion. 1 Publication1
Mutagenesisi229C → A: Impaired secretion of processed zona pellucida sperm-binding protein 3; when associated with A-295. 1 Publication1
Mutagenesisi235P → D: Abolishes secretion of processed zona pellucida sperm-binding protein 3. 1 Publication1
Mutagenesisi241P → A: No effect on dimerization or secretion. 1 Publication1
Mutagenesisi251C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-335. 1 Publication1
Mutagenesisi292Y → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3. 1 Publication1
Mutagenesisi295C → A: Impaired secretion of processed zona pellucida sperm-binding protein 3; when associated with A-229. 1
Mutagenesisi313C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-332. 1 Publication1
Mutagenesisi332C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-313. 1 Publication1
Mutagenesisi334C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-340. 1 Publication1
Mutagenesisi335C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-251. 1 Publication1
Mutagenesisi340C → A: Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-334. 1 Publication1
Mutagenesisi359 – 362RFRR → AFAA: Abolishes cleavage of C-terminal propeptide. 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000040543121 – 360Zona pellucida sperm-binding protein 3Add BLAST340
ChainiPRO_000040543221 – ?Processed zona pellucida sperm-binding protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000405433361 – 437Removed in mature formBy similarityAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 1521 Publication
Disulfide bondi90 ↔ 1111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi168O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi229 ↔ 2951 Publication
Disulfide bondi251 ↔ 3351 Publication
Disulfide bondi313 ↔ 3321 Publication
Disulfide bondi334 ↔ 3401 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
N-glycosylated.
O-glycosylated. O-glycosylation at Thr-168 is important for efficient interaction with the sperm head.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P79762

PRoteomics IDEntifications database

More...
PRIDEi
P79762

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P79762

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the ovarian perivitteline layer. Detected in granulosa cells in ovarian follicle (at protein level). Detected in granulosa cells in ovarian follicle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000001559, Expressed in testis and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P79762, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms higher oligomers, once its C-terminus has been proteolytically removed. Forms heterooligomers with other zona pellucida glycoproteins (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P79762
With#Exp.IntAct
itself3EBI-2942236,EBI-2942236

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000002368

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P79762

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 320ZPPROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni368 – 380Extracellular hydrophobic patchAdd BLAST13

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZP domain family. ZPC subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSZF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047091_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P79762

KEGG Orthology (KO)

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KOi
K19928

Identification of Orthologs from Complete Genome Data

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OMAi
GPAACKH

Database of Orthologous Groups

More...
OrthoDBi
495227at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P79762

TreeFam database of animal gene trees

More...
TreeFami
TF331369

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040196, ZP3
IPR001507, ZP_dom
IPR017977, ZP_dom_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11576:SF2, PTHR11576:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00100, Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00023, ZPELLUCIDA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00241, ZP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P79762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGGRVVLGL LCCLVAGVGS YTPWDISWAA RGDPSAWSWG AEAHSRAVAG
60 70 80 90 100
SHPVAVQCQE AQLVVTVHRD LFGTGRLINA ADLTLGPAAC KHSSLNAAHN
110 120 130 140 150
TVTFAAGLHE CGSVVQVTPD TLIYRTLINY DPSPASNPVI IRTNPAVIPI
160 170 180 190 200
ECHYPRRENV SSNAIRPTWS PFNSALSAEE RLVFSLRLMS DDWSTERPFT
210 220 230 240 250
GFQLGDILNI QAEVSTENHV PLRLFVDSCV AALSPDGDSS PHYAIIDFNG
260 270 280 290 300
CLVDGRVDDT SSAFITPRPR EDVLRFRIDV FRFAGDNRNL IYITCHLKVT
310 320 330 340 350
PADQGPDPQN KACSFNKARN TWVPVEGSRD VCNCCETGNC EPPALSRRLN
360 370 380 390 400
PMERWQSRRF RRDAGKEVAA DVVIGPVLLS ADPGAVGQQE EGGDGAAVMV
410 420 430
PSVGTGLVCV AVAVALAAVG VAVGIARKGC TRTSAAV
Length:437
Mass (Da):46,766
Last modified:March 8, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9B59E9DE71819B3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAV35179 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35180 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35181 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35182 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35183 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35184 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35185 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35186 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35187 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35188 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35189 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35190 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35191 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35192 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35193 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35194 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35195 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35196 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35197 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35198 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35199 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35200 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAV35201 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA83418 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43A → V in AAV35184 (PubMed:16283938).Curated1
Sequence conflicti48V → M in AAV35193 (PubMed:16283938).Curated1
Sequence conflicti48V → M in AAV35180 (PubMed:16283938).Curated1
Sequence conflicti48V → M in AAV35179 (PubMed:16283938).Curated1
Sequence conflicti424G → C in BAA13760 (PubMed:10103002).Curated1
Sequence conflicti424G → C in BAA83418 (Ref. 3) Curated1
Sequence conflicti435A → T in BAA13760 (PubMed:10103002).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D89097 mRNA Translation: BAA13760.3
AY628608 Genomic DNA Translation: AAV35179.1 Different initiation.
AY628609 Genomic DNA Translation: AAV35180.1 Different initiation.
AY628610 Genomic DNA Translation: AAV35181.1 Different initiation.
AY628611 Genomic DNA Translation: AAV35182.1 Different initiation.
AY628612 Genomic DNA Translation: AAV35183.1 Different initiation.
AY628613 Genomic DNA Translation: AAV35184.1 Different initiation.
AY628614 Genomic DNA Translation: AAV35185.1 Different initiation.
AY628615 Genomic DNA Translation: AAV35186.1 Different initiation.
AY628616 Genomic DNA Translation: AAV35187.1 Different initiation.
AY628617 Genomic DNA Translation: AAV35188.1 Different initiation.
AY628618 Genomic DNA Translation: AAV35189.1 Different initiation.
AY628619 Genomic DNA Translation: AAV35190.1 Different initiation.
AY628620 Genomic DNA Translation: AAV35191.1 Different initiation.
AY628621 Genomic DNA Translation: AAV35192.1 Different initiation.
AY628622 Genomic DNA Translation: AAV35193.1 Different initiation.
AY628623 Genomic DNA Translation: AAV35194.1 Different initiation.
AY628624 Genomic DNA Translation: AAV35195.1 Different initiation.
AY628625 Genomic DNA Translation: AAV35196.1 Different initiation.
AY628626 Genomic DNA Translation: AAV35197.1 Different initiation.
AY628627 Genomic DNA Translation: AAV35198.1 Different initiation.
AY628628 Genomic DNA Translation: AAV35199.1 Different initiation.
AY628629 Genomic DNA Translation: AAV35200.1 Different initiation.
AY628630 Genomic DNA Translation: AAV35201.1 Different initiation.
AB031033 Genomic DNA Translation: BAA83418.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_989720.3, NM_204389.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSGALT00000002370; ENSGALP00000002368; ENSGALG00000001559

Database of genes from NCBI RefSeq genomes

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GeneIDi
378906

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
gga:378906

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89097 mRNA Translation: BAA13760.3
AY628608 Genomic DNA Translation: AAV35179.1 Different initiation.
AY628609 Genomic DNA Translation: AAV35180.1 Different initiation.
AY628610 Genomic DNA Translation: AAV35181.1 Different initiation.
AY628611 Genomic DNA Translation: AAV35182.1 Different initiation.
AY628612 Genomic DNA Translation: AAV35183.1 Different initiation.
AY628613 Genomic DNA Translation: AAV35184.1 Different initiation.
AY628614 Genomic DNA Translation: AAV35185.1 Different initiation.
AY628615 Genomic DNA Translation: AAV35186.1 Different initiation.
AY628616 Genomic DNA Translation: AAV35187.1 Different initiation.
AY628617 Genomic DNA Translation: AAV35188.1 Different initiation.
AY628618 Genomic DNA Translation: AAV35189.1 Different initiation.
AY628619 Genomic DNA Translation: AAV35190.1 Different initiation.
AY628620 Genomic DNA Translation: AAV35191.1 Different initiation.
AY628621 Genomic DNA Translation: AAV35192.1 Different initiation.
AY628622 Genomic DNA Translation: AAV35193.1 Different initiation.
AY628623 Genomic DNA Translation: AAV35194.1 Different initiation.
AY628624 Genomic DNA Translation: AAV35195.1 Different initiation.
AY628625 Genomic DNA Translation: AAV35196.1 Different initiation.
AY628626 Genomic DNA Translation: AAV35197.1 Different initiation.
AY628627 Genomic DNA Translation: AAV35198.1 Different initiation.
AY628628 Genomic DNA Translation: AAV35199.1 Different initiation.
AY628629 Genomic DNA Translation: AAV35200.1 Different initiation.
AY628630 Genomic DNA Translation: AAV35201.1 Different initiation.
AB031033 Genomic DNA Translation: BAA83418.1 Different initiation.
RefSeqiNP_989720.3, NM_204389.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NK3X-ray2.60A/B53-347[»]
C/D359-382[»]
3NK4X-ray2.00A/B53-347[»]
C/D359-382[»]
SMRiP79762
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002368

PTM databases

iPTMnetiP79762

Proteomic databases

PaxDbiP79762
PRIDEiP79762

Genome annotation databases

EnsembliENSGALT00000002370; ENSGALP00000002368; ENSGALG00000001559
GeneIDi378906
KEGGigga:378906

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7784

Phylogenomic databases

eggNOGiENOG502QSZF, Eukaryota
GeneTreeiENSGT01000000214546
HOGENOMiCLU_047091_1_1_1
InParanoidiP79762
KOiK19928
OMAiGPAACKH
OrthoDBi495227at2759
PhylomeDBiP79762
TreeFamiTF331369

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P79762

Gene expression databases

BgeeiENSGALG00000001559, Expressed in testis and 5 other tissues
ExpressionAtlasiP79762, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR040196, ZP3
IPR001507, ZP_dom
IPR017977, ZP_dom_CS
PANTHERiPTHR11576:SF2, PTHR11576:SF2, 1 hit
PfamiView protein in Pfam
PF00100, Zona_pellucida, 1 hit
PRINTSiPR00023, ZPELLUCIDA
SMARTiView protein in SMART
SM00241, ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682, ZP_1, 1 hit
PS51034, ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZP3_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P79762
Secondary accession number(s): Q4VU46
, Q4VU49, Q4VU50, Q4VU53, Q4VU54, Q4VU57, Q4VU62, Q4VU63, Q4VU66, Q9PWF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: August 12, 2020
This is version 116 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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