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UniProtKB - P79522 (PRR3_HUMAN)

Entry version 148 (11 Dec 2019)
Sequence version 2 (15 Feb 2005)
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Protein

Proline-rich protein 3

Gene

PRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 3
Alternative name(s):
MHC class I region proline-rich protein CAT56
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR3
Synonyms:CAT56
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204576.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:21149 PRR3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P79522

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80742

Open Targets

More...OpenTargetsi		ENSG00000204576

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134950097

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P79522 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRR3

Domain mapping of disease mutations (DMDM)

More...DMDMi		59798092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138891 – 188Proline-rich protein 3Add BLAST188

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P79522

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P79522

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P79522

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P79522

PeptideAtlas

More...PeptideAtlasi		P79522

PRoteomics IDEntifications database

More...PRIDEi		P79522

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57662 [P79522-1]
57663 [P79522-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P79522

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P79522

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P79522 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P79522 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA064061

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123286, 30 interactors

Protein interaction database and analysis system

More...IntActi		P79522, 34 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365744

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P79522 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 118Pro-richAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J4IA Eukaryota
ENOG4111CMK LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161804

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P79522

Identification of Orthologs from Complete Genome Data

More...OMAi		ESPIGPP

Database of Orthologous Groups

More...OrthoDBi		1475853at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P79522

TreeFam database of animal gene trees

More...TreeFami		TF337284

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042805 PRR3
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

The PANTHER Classification System

More...PANTHERi		PTHR47398 PTHR47398, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00642 zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P79522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK 
        60         70         80         90        100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG 
       110        120        130        140        150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ 
       160        170        180 
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL
Length:188
Mass (Da):20,640
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EFDAFB4FFBBE153
GO
Isoform 2 (identifier: P79522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-56: Missing.

Show »
Length:167
Mass (Da):18,644
Checksum:i83E9572CC89E30D4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB40147 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05296361G → S1 PublicationCorresponds to variant dbSNP:rs3888778Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01281836 – 56Missing in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U63336 mRNA Translation: AAB40147.1 Different initiation.
AL662825 Genomic DNA No translation available.
AL662800 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR847863 Genomic DNA No translation available.
BC126457 mRNA Translation: AAI26458.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43440.1 [P79522-1]
CCDS43441.1 [P79522-2]

NCBI Reference Sequences

More...RefSeqi		NP_079539.2, NM_025263.3 [P79522-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80742

UCSC genome browser

More...UCSCi		uc003nqj.3 human [P79522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA Translation: AAB40147.1 Different initiation.
AL662825 Genomic DNA No translation available.
AL662800 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR847863 Genomic DNA No translation available.
BC126457 mRNA Translation: AAI26458.1
CCDSiCCDS43440.1 [P79522-1]
CCDS43441.1 [P79522-2]
RefSeqiNP_079539.2, NM_025263.3 [P79522-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi123286, 30 interactors
IntActiP79522, 34 interactors
STRINGi9606.ENSP00000365744

PTM databases

iPTMnetiP79522
PhosphoSitePlusiP79522

Polymorphism and mutation databases

BioMutaiPRR3
DMDMi59798092

Proteomic databases

EPDiP79522
jPOSTiP79522
MassIVEiP79522
PaxDbiP79522
PeptideAtlasiP79522
PRIDEiP79522
ProteomicsDBi57662 [P79522-1]
57663 [P79522-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		80742

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]
GeneIDi80742
KEGGihsa:80742
UCSCiuc003nqj.3 human [P79522-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80742
DisGeNETi80742
EuPathDBiHostDB:ENSG00000204576.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRR3
HGNCiHGNC:21149 PRR3
HPAiHPA064061
neXtProtiNX_P79522
OpenTargetsiENSG00000204576
PharmGKBiPA134950097

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J4IA Eukaryota
ENOG4111CMK LUCA
GeneTreeiENSGT00940000161804
InParanoidiP79522
OMAiESPIGPP
OrthoDBi1475853at2759
PhylomeDBiP79522
TreeFamiTF337284

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRR3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80742
PharosiP79522 Tdark

Protein Ontology

More...PROi		PR:P79522
RNActiP79522 protein

Gene expression databases

BgeeiENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiP79522 baseline and differential
GenevisibleiP79522 HS

Family and domain databases

InterProiView protein in InterPro
IPR042805 PRR3
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PANTHERiPTHR47398 PTHR47398, 1 hit
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P79522
Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: December 11, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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