UniProtKB - P79522 (PRR3_HUMAN)
Protein
Proline-rich protein 3
Gene
PRR3
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 183 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P79522 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-rich protein 3Alternative name(s): MHC class I region proline-rich protein CAT56 |
Gene namesi | Name:PRR3 Synonyms:CAT56 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21149, PRR3 |
neXtProti | NX_P79522 |
VEuPathDBi | HostDB:ENSG00000204576.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 80742 |
OpenTargetsi | ENSG00000204576 |
PharmGKBi | PA134950097 |
Miscellaneous databases
Pharosi | P79522, Tdark |
Genetic variation databases
BioMutai | PRR3 |
DMDMi | 59798092 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213889 | 1 – 188 | Proline-rich protein 3Add BLAST | 188 |
Proteomic databases
EPDi | P79522 |
jPOSTi | P79522 |
MassIVEi | P79522 |
PaxDbi | P79522 |
PeptideAtlasi | P79522 |
PRIDEi | P79522 |
ProteomicsDBi | 57662 [P79522-1] 57663 [P79522-2] |
PTM databases
iPTMneti | P79522 |
MetOSitei | P79522 |
PhosphoSitePlusi | P79522 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204576, Expressed in cortical plate and 153 other tissues |
ExpressionAtlasi | P79522, baseline and differential |
Genevisiblei | P79522, HS |
Organism-specific databases
HPAi | ENSG00000204576, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP79522
Protein-protein interaction databases
BioGRIDi | 123286, 43 interactors |
IntActi | P79522, 40 interactors |
STRINGi | 9606.ENSP00000365744 |
Miscellaneous databases
RNActi | P79522, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 118 | Pro-richAdd BLAST | 107 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 183 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502TAPB, Eukaryota |
GeneTreei | ENSGT00940000161804 |
HOGENOMi | CLU_112270_0_0_1 |
InParanoidi | P79522 |
OMAi | ESPIGPP |
PhylomeDBi | P79522 |
TreeFami | TF337284 |
Family and domain databases
InterProi | View protein in InterPro IPR042805, PRR3 IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
PANTHERi | PTHR47398, PTHR47398, 1 hit |
Pfami | View protein in Pfam PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P79522-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK
60 70 80 90 100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG
110 120 130 140 150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ
160 170 180
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL
Sequence cautioni
The sequence AAB40147 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052963 | 61 | G → S1 PublicationCorresponds to variant dbSNP:rs3888778Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012818 | 36 – 56 | Missing in isoform 2. CuratedAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63336 mRNA Translation: AAB40147.1 Different initiation. AL662825 Genomic DNA No translation available. AL662800 Genomic DNA No translation available. BX000357 Genomic DNA No translation available. BX248518 Genomic DNA No translation available. BX927220 Genomic DNA No translation available. CR388372 Genomic DNA No translation available. CR847863 Genomic DNA No translation available. BC126457 mRNA Translation: AAI26458.1 |
CCDSi | CCDS43440.1 [P79522-1] CCDS43441.1 [P79522-2] |
RefSeqi | NP_079539.2, NM_025263.3 [P79522-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63336 mRNA Translation: AAB40147.1 Different initiation. AL662825 Genomic DNA No translation available. AL662800 Genomic DNA No translation available. BX000357 Genomic DNA No translation available. BX248518 Genomic DNA No translation available. BX927220 Genomic DNA No translation available. CR388372 Genomic DNA No translation available. CR847863 Genomic DNA No translation available. BC126457 mRNA Translation: AAI26458.1 |
CCDSi | CCDS43440.1 [P79522-1] CCDS43441.1 [P79522-2] |
RefSeqi | NP_079539.2, NM_025263.3 [P79522-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123286, 43 interactors |
IntActi | P79522, 40 interactors |
STRINGi | 9606.ENSP00000365744 |
PTM databases
iPTMneti | P79522 |
MetOSitei | P79522 |
PhosphoSitePlusi | P79522 |
Genetic variation databases
BioMutai | PRR3 |
DMDMi | 59798092 |
Proteomic databases
EPDi | P79522 |
jPOSTi | P79522 |
MassIVEi | P79522 |
PaxDbi | P79522 |
PeptideAtlasi | P79522 |
PRIDEi | P79522 |
ProteomicsDBi | 57662 [P79522-1] 57663 [P79522-2] |
Protocols and materials databases
Antibodypediai | 67374, 30 antibodies |
DNASUi | 80742 |
Genome annotation databases
Organism-specific databases
CTDi | 80742 |
DisGeNETi | 80742 |
GeneCardsi | PRR3 |
HGNCi | HGNC:21149, PRR3 |
HPAi | ENSG00000204576, Low tissue specificity |
neXtProti | NX_P79522 |
OpenTargetsi | ENSG00000204576 |
PharmGKBi | PA134950097 |
VEuPathDBi | HostDB:ENSG00000204576.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TAPB, Eukaryota |
GeneTreei | ENSGT00940000161804 |
HOGENOMi | CLU_112270_0_0_1 |
InParanoidi | P79522 |
OMAi | ESPIGPP |
PhylomeDBi | P79522 |
TreeFami | TF337284 |
Enzyme and pathway databases
PathwayCommonsi | P79522 |
Miscellaneous databases
BioGRID-ORCSi | 80742, 11 hits in 988 CRISPR screens |
ChiTaRSi | PRR3, human |
GenomeRNAii | 80742 |
Pharosi | P79522, Tdark |
PROi | PR:P79522 |
RNActi | P79522, protein |
Gene expression databases
Bgeei | ENSG00000204576, Expressed in cortical plate and 153 other tissues |
ExpressionAtlasi | P79522, baseline and differential |
Genevisiblei | P79522, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042805, PRR3 IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
PANTHERi | PTHR47398, PTHR47398, 1 hit |
Pfami | View protein in Pfam PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRR3_HUMAN | |
Accessioni | P79522Primary (citable) accession number: P79522 Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports