PRR3

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	155 – 183	C3H1-typePROSITE-ProRule annotationAdd BLAST		29

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proline-rich protein 3 Alternative name(s): MHC class I region proline-rich protein CAT56
Gene namesⁱ	Name:PRR3 Synonyms:CAT56
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204576.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21149 PRR3
neXtProtⁱ	NX_P79522

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80742
Open Targets More...OpenTargetsⁱ	ENSG00000204576
PharmGKBⁱ	PA134950097

Polymorphism and mutation databases

BioMutaⁱ	PRR3
DMDMⁱ	59798092

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213889	1 – 188	Proline-rich protein 3Add BLAST		188

Proteomic databases

EPDⁱ	P79522
PaxDbⁱ	P79522
PeptideAtlas More...PeptideAtlasⁱ	P79522
PRIDEⁱ	P79522
ProteomicsDBⁱ	57662 57663 [P79522-2]

PTM databases

iPTMnetⁱ	P79522
PhosphoSitePlusⁱ	P79522

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_PRR3
ExpressionAtlasⁱ	P79522 baseline and differential
Genevisibleⁱ	P79522 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064061

HPAⁱ

HPA064061

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-2803328,EBI-717810
ASF1A	Q9Y294	5	EBI-2803328,EBI-749553
CCDC57	Q2TAC2	3	EBI-2803328,EBI-2808286
HNRNPK	P61978	6	EBI-2803328,EBI-304185
KHDRBS2	Q5VWX1	5	EBI-2803328,EBI-742808
PSMA3	P25788	3	EBI-2803328,EBI-348380
RBMX	P38159	5	EBI-2803328,EBI-743526
RBMY1A1	P0DJD3	3	EBI-2803328,EBI-8638511
RBMY1J	Q15415	5	EBI-2803328,EBI-8642021

Protein-protein interaction databases

BioGridⁱ	123286, 30 interactors
IntActⁱ	P79522, 30 interactors
STRINGⁱ	9606.ENSP00000365744

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P79522
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	12 – 118	Pro-richAdd BLAST		107

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	155 – 183	C3H1-typePROSITE-ProRule annotationAdd BLAST		29

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410J4IA Eukaryota ENOG4111CMK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063820
HOVERGENⁱ	HBG053700
InParanoidⁱ	P79522
OMAⁱ	SAFHRGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07K1
PhylomeDBⁱ	P79522
TreeFamⁱ	TF337284

Family and domain databases

InterProⁱ	View protein in InterPro IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00642 zf-CCCH, 1 hit
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 1 hit
SUPFAMⁱ	SSF90229 SSF90229, 1 hit
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P79522-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK 
        60         70         80         90        100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG 
       110        120        130        140        150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ 
       160        170        180 
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL

Length:188

Mass (Da):20,640

Last modified:February 15, 2005 - v2

Checksum:ⁱ1EFDAFB4FFBBE153

GO

Isoform 2 (identifier: P79522-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
36-56: Missing.

« Hide

        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIALHRG PPGSRGPLIP 
        60         70         80         90        100
PLLSLPPPPW GRGPIRRGLG PRSSPYGRGW WGVNAEPPFP GPGHGGPTRG 
       110        120        130        140        150
SFHKEQRNPR RLKSWSLIKN TCPPKDDPQV MEDKSDRPVC RHFAKKGHCR 
       160 
YEDLCAFYHP GVNGPPL

Note: No experimental confirmation available.

Show »

Length:167

Mass (Da):18,644

Checksum:ⁱ83E9572CC89E30D4

GO

Sequence cautionⁱ

The sequence AAB40147 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052963	61	G → S1 PublicationCorresponds to variant dbSNP:rs3888778Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012818	36 – 56	Missing in isoform 2. CuratedAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63336 mRNA Translation: AAB40147.1 Different initiation. AL662825 Genomic DNA No translation available. AL662800 Genomic DNA No translation available. BX000357 Genomic DNA No translation available. BX248518 Genomic DNA No translation available. BX927220 Genomic DNA No translation available. CR388372 Genomic DNA No translation available. CR847863 Genomic DNA No translation available. BC126457 mRNA Translation: AAI26458.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43440.1 [P79522-1] CCDS43441.1 [P79522-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_079539.2, NM_025263.3 [P79522-1]
UniGeneⁱ	Hs.118354 Hs.651434

Genome annotation databases

Ensemblⁱ	ENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2] ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1] ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1] ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2] ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2] ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2] ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1] ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1] ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2] ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2] ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2] ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1] ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1] ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]
GeneIDⁱ	80742
KEGGⁱ	hsa:80742
UCSC genome browser More...UCSCⁱ	uc003nqj.3 human [P79522-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P79522	cDNA, FLJ95224, Homo sapiens proline rich 3 (PRR3), mRNA		HUMAN		253	UniRef100_P79522
CAT56 protein		HUMAN		188

Protein	Similar proteins		Species	Score	Length	Source
P79522	Proline-rich protein 3		PANTR		188	UniRef90_P79522
cDNA, FLJ95224, Homo sapiens proline rich 3 (PRR3), mRNA		HUMAN		253
Proline rich 3		COLAP		251
Proline rich 3		RHIRO		188
Proline rich 3		RHIBE		188
+20
P79522-2	Proline rich 3		CALJA		179	UniRef90_P79522-2
cDNA FLJ90050 fis, clone HEMBA1002524, highly similar to Proline-rich protein 3		HUMAN		167
proline-rich protein 3 isoform X3		Enhydra lutris kenyoni		167
Proline rich 3		MACFA		167
Proline rich 3		CERAT		167
+28

Protein	Similar proteins		Species	Score	Length	Source
P79522	Proline-rich protein 3		PANTR		188	UniRef50_P79522
cDNA, FLJ95224, Homo sapiens proline rich 3 (PRR3), mRNA		HUMAN		253
Proline rich 3		COLAP		251
Proline rich 3		RHIRO		188
Proline rich 3		RHIBE		188
+42
P79522-2	Proline rich 3		CALJA		179	UniRef50_P79522-2
Uncharacterized protein		GORGO		167
Proline rich 3		AOTNA		167
Proline rich 3		PROCO		167
Proline rich 3		SAIBB		167
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63336 mRNA Translation: AAB40147.1 Different initiation. AL662825 Genomic DNA No translation available. AL662800 Genomic DNA No translation available. BX000357 Genomic DNA No translation available. BX248518 Genomic DNA No translation available. BX927220 Genomic DNA No translation available. CR388372 Genomic DNA No translation available. CR847863 Genomic DNA No translation available. BC126457 mRNA Translation: AAI26458.1
CCDSⁱ	CCDS43440.1 [P79522-1] CCDS43441.1 [P79522-2]
RefSeqⁱ	NP_079539.2, NM_025263.3 [P79522-1]
UniGeneⁱ	Hs.118354 Hs.651434

3D structure databases

ProteinModelPortalⁱ	P79522
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123286, 30 interactors
IntActⁱ	P79522, 30 interactors
STRINGⁱ	9606.ENSP00000365744

PTM databases

iPTMnetⁱ	P79522
PhosphoSitePlusⁱ	P79522

Polymorphism and mutation databases

BioMutaⁱ	PRR3
DMDMⁱ	59798092

Proteomic databases

EPDⁱ	P79522
PaxDbⁱ	P79522
PeptideAtlasⁱ	P79522
PRIDEⁱ	P79522
ProteomicsDBⁱ	57662 57663 [P79522-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80742
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2] ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1] ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1] ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2] ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2] ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2] ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1] ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1] ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2] ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2] ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2] ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1] ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1] ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]
GeneIDⁱ	80742
KEGGⁱ	hsa:80742
UCSCⁱ	uc003nqj.3 human [P79522-1]

Organism-specific databases

CTDⁱ	80742
DisGeNETⁱ	80742
EuPathDBⁱ	HostDB:ENSG00000204576.11
GeneCardsⁱ	PRR3
HGNCⁱ	HGNC:21149 PRR3
HPAⁱ	HPA064061
neXtProtⁱ	NX_P79522
OpenTargetsⁱ	ENSG00000204576
PharmGKBⁱ	PA134950097
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4IA Eukaryota ENOG4111CMK LUCA
GeneTreeⁱ	ENSGT00530000063820
HOVERGENⁱ	HBG053700
InParanoidⁱ	P79522
OMAⁱ	SAFHRGP
OrthoDBⁱ	EOG091G07K1
PhylomeDBⁱ	P79522
TreeFamⁱ	TF337284

Miscellaneous databases

GenomeRNAiⁱ	80742
Protein Ontology More...PROⁱ	PR:P79522

Gene expression databases

Bgeeⁱ	ENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_PRR3
ExpressionAtlasⁱ	P79522 baseline and differential
Genevisibleⁱ	P79522 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfamⁱ	View protein in Pfam PF00642 zf-CCCH, 1 hit
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 1 hit
SUPFAMⁱ	SSF90229 SSF90229, 1 hit
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRR3_HUMAN
Accessionⁱ	P79522Primary (citable) accession number: P79522 Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	February 15, 2005
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P79522 (PRR3_HUMAN)

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Proline-rich protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ