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Protein

Proline-rich protein 3

Gene

PRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 3
Alternative name(s):
MHC class I region proline-rich protein CAT56
Gene namesi
Name:PRR3
Synonyms:CAT56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204576.11
HGNCiHGNC:21149 PRR3
neXtProtiNX_P79522

Pathology & Biotechi

Organism-specific databases

DisGeNETi80742
OpenTargetsiENSG00000204576
PharmGKBiPA134950097

Polymorphism and mutation databases

BioMutaiPRR3
DMDMi59798092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138891 – 188Proline-rich protein 3Add BLAST188

Proteomic databases

EPDiP79522
PaxDbiP79522
PeptideAtlasiP79522
PRIDEiP79522
ProteomicsDBi57662
57663 [P79522-2]

PTM databases

iPTMnetiP79522
PhosphoSitePlusiP79522

Expressioni

Gene expression databases

BgeeiENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_PRR3
ExpressionAtlasiP79522 baseline and differential
GenevisibleiP79522 HS

Organism-specific databases

HPAiHPA064061

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123286, 30 interactors
IntActiP79522, 30 interactors
STRINGi9606.ENSP00000365744

Structurei

3D structure databases

ProteinModelPortaliP79522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 118Pro-richAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J4IA Eukaryota
ENOG4111CMK LUCA
GeneTreeiENSGT00530000063820
HOVERGENiHBG053700
InParanoidiP79522
OMAiSAFHRGP
OrthoDBiEOG091G07K1
PhylomeDBiP79522
TreeFamiTF337284

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P79522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK
60 70 80 90 100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG
110 120 130 140 150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ
160 170 180
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL
Length:188
Mass (Da):20,640
Last modified:February 15, 2005 - v2
Checksum:i1EFDAFB4FFBBE153
GO
Isoform 2 (identifier: P79522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-56: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,644
Checksum:i83E9572CC89E30D4
GO

Sequence cautioni

The sequence AAB40147 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05296361G → S1 PublicationCorresponds to variant dbSNP:rs3888778Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01281836 – 56Missing in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA Translation: AAB40147.1 Different initiation.
AL662825 Genomic DNA No translation available.
AL662800 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR847863 Genomic DNA No translation available.
BC126457 mRNA Translation: AAI26458.1
CCDSiCCDS43440.1 [P79522-1]
CCDS43441.1 [P79522-2]
RefSeqiNP_079539.2, NM_025263.3 [P79522-1]
UniGeneiHs.118354
Hs.651434

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]
GeneIDi80742
KEGGihsa:80742
UCSCiuc003nqj.3 human [P79522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA Translation: AAB40147.1 Different initiation.
AL662825 Genomic DNA No translation available.
AL662800 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR847863 Genomic DNA No translation available.
BC126457 mRNA Translation: AAI26458.1
CCDSiCCDS43440.1 [P79522-1]
CCDS43441.1 [P79522-2]
RefSeqiNP_079539.2, NM_025263.3 [P79522-1]
UniGeneiHs.118354
Hs.651434

3D structure databases

ProteinModelPortaliP79522
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123286, 30 interactors
IntActiP79522, 30 interactors
STRINGi9606.ENSP00000365744

PTM databases

iPTMnetiP79522
PhosphoSitePlusiP79522

Polymorphism and mutation databases

BioMutaiPRR3
DMDMi59798092

Proteomic databases

EPDiP79522
PaxDbiP79522
PeptideAtlasiP79522
PRIDEiP79522
ProteomicsDBi57662
57663 [P79522-2]

Protocols and materials databases

DNASUi80742
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576 [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576 [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491 [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491 [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186 [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202 [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766 [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186 [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564 [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887 [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766 [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564 [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202 [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887 [P79522-1]
GeneIDi80742
KEGGihsa:80742
UCSCiuc003nqj.3 human [P79522-1]

Organism-specific databases

CTDi80742
DisGeNETi80742
EuPathDBiHostDB:ENSG00000204576.11
GeneCardsiPRR3
HGNCiHGNC:21149 PRR3
HPAiHPA064061
neXtProtiNX_P79522
OpenTargetsiENSG00000204576
PharmGKBiPA134950097
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4IA Eukaryota
ENOG4111CMK LUCA
GeneTreeiENSGT00530000063820
HOVERGENiHBG053700
InParanoidiP79522
OMAiSAFHRGP
OrthoDBiEOG091G07K1
PhylomeDBiP79522
TreeFamiTF337284

Miscellaneous databases

GenomeRNAii80742
PROiPR:P79522

Gene expression databases

BgeeiENSG00000204576 Expressed in 135 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_PRR3
ExpressionAtlasiP79522 baseline and differential
GenevisibleiP79522 HS

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRR3_HUMAN
AccessioniPrimary (citable) accession number: P79522
Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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