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Protein

HLA class II histocompatibility antigen, DR beta 3 chain

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P79483

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR beta 3 chain
Alternative name(s):
MHC class II antigen DRB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4951 HLA-DRB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612735 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P79483

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 227ExtracellularSequence analysisAdd BLAST198
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei228 – 250HelicalSequence analysisAdd BLAST23
Topological domaini251 – 266CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3125

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35074

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3460

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395491

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Add BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001895630 – 266HLA class II histocompatibility antigen, DR beta 3 chainAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 108
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 202

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P79483

PeptideAtlas

More...
PeptideAtlasi
P79483

PRoteomics IDEntifications database

More...
PRIDEi
P79483

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57661

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P79483

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1377

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P79483

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P79483

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P79483

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043151

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109370, 14 interactors

Protein interaction database and analysis system

More...
IntActi
P79483, 3 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P79483

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P79483

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P79483

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P79483

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 214Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 124Beta-1Add BLAST95
Regioni125 – 227Beta-2Add BLAST103

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG012730

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P79483

KEGG Orthology (KO)

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KOi
K06752

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P79483

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P79483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):29,962
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC3AE68D3B10EAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A182DWH4A0A182DWH4_HUMAN
HLA class II histocompatibility ant...
HLA-DRB3
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimmune thrombocytopenia (NAIT).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06073937L → S in allele DRB3*01:04. 1
Natural variantiVAR_06074038E → Q in allele DRB3*02:12. Corresponds to variant dbSNP:rs1071747Ensembl.1
Natural variantiVAR_06074139L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01668640R → C in allele DRB3*01:02. 1
Natural variantiVAR_06074240R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs1071748Ensembl.1
Natural variantiVAR_06074340R → S in allele DRB3*01:14. Corresponds to variant dbSNP:rs1136752Ensembl.1
Natural variantiVAR_06074441K → T in allele DRB3*01:14. Corresponds to variant dbSNP:rs200581589Ensembl.1
Natural variantiVAR_06074655Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs147440497Ensembl.1
Natural variantiVAR_06074555Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06074757D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs202185589Ensembl.1
Natural variantiVAR_06074857D → N in allele DRB3*01:05. Corresponds to variant dbSNP:rs142793258Ensembl.1
Natural variantiVAR_06074958R → I in allele DRB3*01:11. 1
Natural variantiVAR_06075059Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02. Corresponds to variant dbSNP:rs138849995Ensembl.1
Natural variantiVAR_06075266F → L in allele DRB3*01:13. Corresponds to variant dbSNP:rs707956Ensembl.1
Natural variantiVAR_06075366F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075166F → S in allele DRB3*02:03. Corresponds to variant dbSNP:rs200042906Ensembl.1
Natural variantiVAR_06075466F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs200042906Ensembl.1
Natural variantiVAR_06075567L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075667L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs1059580Ensembl.1
Natural variantiVAR_06075768R → S in allele DRB3*01:10. Corresponds to variant dbSNP:rs774894415Ensembl.1
Natural variantiVAR_06075880T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs79606458Ensembl.1
Natural variantiVAR_06075984R → L in allele DRB3*02:23. 1
Natural variantiVAR_06076086V → A in allele DRB3*02:16. Corresponds to variant dbSNP:rs144532965Ensembl.1
Natural variantiVAR_06076286V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs144532965Ensembl.1
Natural variantiVAR_06076186V → S in allele DRB3*02:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076387A → E in allele DRB3*02:18. 1
Natural variantiVAR_06076489S → H in allele DRB3*02:16; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076589S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24. Corresponds to variant dbSNP:rs41541218Ensembl.1
Natural variantiVAR_06076696L → F in allele DRB3*02:17. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_06076796L → I in allele DRB3*02:11. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_033396102G → A. Corresponds to variant dbSNP:rs17878857Ensembl.1
Natural variantiVAR_060768103R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant dbSNP:rs1059598Ensembl.1
Natural variantiVAR_060769106N → T in allele DRB3*02:15. Corresponds to variant dbSNP:rs115817940Ensembl.1
Natural variantiVAR_060770113G → R in allele DRB3*01:12. 1
Natural variantiVAR_033397114V → A. Corresponds to variant dbSNP:rs1136778Ensembl.1
Natural variantiVAR_060771115G → A in allele DRB3*02:14. 1
Natural variantiVAR_060772115G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant dbSNP:rs41556512Ensembl.1
Natural variantiVAR_060773169A → T in allele DRB3*03:01. Corresponds to variant dbSNP:rs75709987Ensembl.1
Natural variantiVAR_060774178Q → H in allele DRB3*03:01. Corresponds to variant dbSNP:rs139485758Ensembl.1
Natural variantiVAR_060775193V → F in allele DRB3*02:01. 1
Natural variantiVAR_060776212A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01. Corresponds to variant dbSNP:rs142204283Ensembl.1
Natural variantiVAR_060777218R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11. Corresponds to variant dbSNP:rs147669022Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00522 mRNA Translation: CAA23781.1
X04055 Genomic DNA No translation available.
X04058 Genomic DNA No translation available.
U66825 mRNA Translation: AAD43828.1
AF026467 Genomic DNA Translation: AAC05599.1
AF199236 mRNA Translation: AAF13065.2
U95819 mRNA Translation: AAD00819.1
AY138123 mRNA Translation: AAN15205.1
A06800 mRNA Translation: CAA00596.1
AL662842 Genomic DNA No translation available.
AL929581 Genomic DNA No translation available.
CR788283 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06607.1
BC008987 mRNA Translation: AAH08987.1
BC106057 mRNA Translation: AAI06058.1
M17380 mRNA Translation: AAA59804.1
AF192258 mRNA Translation: AAF26358.1
AF192259 mRNA Translation: AAF26359.1
FJ515276 Genomic DNA Translation: ACL50609.1
AY291205 Genomic DNA Translation: AAP43643.1
AF148518 Genomic DNA Translation: AAF67837.1
AF081677 Genomic DNA Translation: AAC32202.1
AY271986 Genomic DNA Translation: AAP23230.1
AM747470 Genomic DNA Translation: CAO00528.1
EU873151 Genomic DNA Translation: ACF33221.1
EU873152 Genomic DNA Translation: ACF33222.1
EU873153 Genomic DNA Translation: ACF33223.1
X91639 Genomic DNA No translation available.
AF208484 Genomic DNA Translation: AAF23165.1
AF208485 Genomic DNA Translation: AAF23166.1
AJ290395 Genomic DNA Translation: CAC27417.1
AF427138 Genomic DNA Translation: AAL26538.1
AF455114 Genomic DNA Translation: AAL57866.1
AF461431 Genomic DNA Translation: AAL66370.1
AJ564210 Genomic DNA Translation: CAD91915.2
AY958608 Genomic DNA Translation: AAY28717.1
DQ311653 Genomic DNA Translation: ABC33924.1
AM413002 Genomic DNA Translation: CAL85628.1
FN424163 Genomic DNA Translation: CAZ66795.1
FN424162 Genomic DNA Translation: CAZ66766.1
AF177216 Genomic DNA Translation: AAD53911.1
AF361865 Genomic DNA Translation: AAK38297.1
AY042679 Genomic DNA Translation: AAK94514.1
U36826 Genomic DNA Translation: AAB63531.1
U94590 Genomic DNA Translation: AAB53324.1
X95760 Genomic DNA Translation: CAA65066.1
Y13715 Genomic DNA Translation: CAA74043.1
AJ001255 Genomic DNA Translation: CAA04629.1
AJ242860 Genomic DNA Translation: CAB62390.1
AJ242862 Genomic DNA Translation: CAB62392.1
AJ315477 Genomic DNA Translation: CAC86562.1
AF028012 Genomic DNA Translation: AAB94614.1
Y08063 Genomic DNA Translation: CAA69301.1
Y10180 Genomic DNA Translation: CAA71253.1
X86977 Genomic DNA No translation available.
AF152845 Genomic DNA Translation: AAD45286.1

Protein sequence database of the Protein Information Resource

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PIRi
B60748
E28043
I37469 HLHU5D
PT0164
PT0165
PT0166
S03442

NCBI Reference Sequences

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RefSeqi
NP_072049.2, NM_022555.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.696211

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307137; ENSP00000302517; ENSG00000196101

Database of genes from NCBI RefSeq genomes

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GeneIDi
3125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3125

UCSC genome browser

More...
UCSCi
uc011fni.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA Translation: CAA23781.1
X04055 Genomic DNA No translation available.
X04058 Genomic DNA No translation available.
U66825 mRNA Translation: AAD43828.1
AF026467 Genomic DNA Translation: AAC05599.1
AF199236 mRNA Translation: AAF13065.2
U95819 mRNA Translation: AAD00819.1
AY138123 mRNA Translation: AAN15205.1
A06800 mRNA Translation: CAA00596.1
AL662842 Genomic DNA No translation available.
AL929581 Genomic DNA No translation available.
CR788283 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06607.1
BC008987 mRNA Translation: AAH08987.1
BC106057 mRNA Translation: AAI06058.1
M17380 mRNA Translation: AAA59804.1
AF192258 mRNA Translation: AAF26358.1
AF192259 mRNA Translation: AAF26359.1
FJ515276 Genomic DNA Translation: ACL50609.1
AY291205 Genomic DNA Translation: AAP43643.1
AF148518 Genomic DNA Translation: AAF67837.1
AF081677 Genomic DNA Translation: AAC32202.1
AY271986 Genomic DNA Translation: AAP23230.1
AM747470 Genomic DNA Translation: CAO00528.1
EU873151 Genomic DNA Translation: ACF33221.1
EU873152 Genomic DNA Translation: ACF33222.1
EU873153 Genomic DNA Translation: ACF33223.1
X91639 Genomic DNA No translation available.
AF208484 Genomic DNA Translation: AAF23165.1
AF208485 Genomic DNA Translation: AAF23166.1
AJ290395 Genomic DNA Translation: CAC27417.1
AF427138 Genomic DNA Translation: AAL26538.1
AF455114 Genomic DNA Translation: AAL57866.1
AF461431 Genomic DNA Translation: AAL66370.1
AJ564210 Genomic DNA Translation: CAD91915.2
AY958608 Genomic DNA Translation: AAY28717.1
DQ311653 Genomic DNA Translation: ABC33924.1
AM413002 Genomic DNA Translation: CAL85628.1
FN424163 Genomic DNA Translation: CAZ66795.1
FN424162 Genomic DNA Translation: CAZ66766.1
AF177216 Genomic DNA Translation: AAD53911.1
AF361865 Genomic DNA Translation: AAK38297.1
AY042679 Genomic DNA Translation: AAK94514.1
U36826 Genomic DNA Translation: AAB63531.1
U94590 Genomic DNA Translation: AAB53324.1
X95760 Genomic DNA Translation: CAA65066.1
Y13715 Genomic DNA Translation: CAA74043.1
AJ001255 Genomic DNA Translation: CAA04629.1
AJ242860 Genomic DNA Translation: CAB62390.1
AJ242862 Genomic DNA Translation: CAB62392.1
AJ315477 Genomic DNA Translation: CAC86562.1
AF028012 Genomic DNA Translation: AAB94614.1
Y08063 Genomic DNA Translation: CAA69301.1
Y10180 Genomic DNA Translation: CAA71253.1
X86977 Genomic DNA No translation available.
AF152845 Genomic DNA Translation: AAD45286.1
PIRiB60748
E28043
I37469 HLHU5D
PT0164
PT0165
PT0166
S03442
RefSeqiNP_072049.2, NM_022555.3
UniGeneiHs.696211

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortaliP79483
SMRiP79483
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109370, 14 interactors
IntActiP79483, 3 interactors

Chemistry databases

BindingDBiP79483
ChEMBLiCHEMBL3460

PTM databases

GlyConnecti1377
iPTMnetiP79483
PhosphoSitePlusiP79483
SwissPalmiP79483

Polymorphism and mutation databases

DMDMi34395491

Proteomic databases

MaxQBiP79483
PeptideAtlasiP79483
PRIDEiP79483
ProteomicsDBi57661
TopDownProteomicsiP79483

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101
GeneIDi3125
KEGGihsa:3125
UCSCiuc011fni.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3125
DisGeNETi3125

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-DRB3
HGNCiHGNC:4951 HLA-DRB3
HPAiHPA043151
MIMi612735 gene
neXtProtiNX_P79483
PharmGKBiPA35074

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

HOVERGENiHBG012730
InParanoidiP79483
KOiK06752
PhylomeDBiP79483

Enzyme and pathway databases

ReactomeiR-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-2132295 MHC class II antigen presentation
R-HSA-389948 PD-1 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP79483

Miscellaneous databases

EvolutionaryTraceiP79483

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HLA-DRB3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3125

Protein Ontology

More...
PROi
PR:P79483

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9
, A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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