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Entry version 163 (07 Apr 2021)
Sequence version 1 (01 May 1997)
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Protein

HLA class II histocompatibility antigen, DR beta 3 chain

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:2788702, PubMed:2463305, PubMed:16148104, PubMed:19531622, PubMed:20368442, PubMed:19830726, PubMed:23569328, PubMed:22929521, PubMed:30282837, PubMed:31020640, PubMed:31333679, PubMed:31308093). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity).By similarity12 Publications
ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702, PubMed:2463305). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640).4 Publications
ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093, PubMed:23569328). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837).10 Publications
ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M. tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C. tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104).3 Publications

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei40Self-peptide antigenCombined sources1 Publication1
Sitei90Self-peptide antigenCombined sources1 Publication1
Sitei100Self-peptide antigenCombined sources1 Publication1
Sitei110Self-peptide antigenCombined sources1 Publication1
Sitei111Self-peptide antigenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P79483

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling

SIGNOR Signaling Network Open Resource

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SIGNORi
P79483

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR beta 3 chain
Alternative name(s):
MHC class II antigen DRB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4951, HLA-DRB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612735, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P79483

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 227ExtracellularSequence analysisAdd BLAST198
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 266CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3125

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35074

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P79483, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3460

Drug and drug target database

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DrugBanki
DB05121, 1D09C3
DB11294, Coccidioides immitis spherule

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DRB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395491

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001895630 – 266HLA class II histocompatibility antigen, DR beta 3 chainSequence analysisAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 108Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi146 ↔ 202Combined sources2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCHF1 and MARCHF8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P79483

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P79483

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P79483

PeptideAtlas

More...
PeptideAtlasi
P79483

PRoteomics IDEntifications database

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PRIDEi
P79483

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57661

Consortium for Top Down Proteomics

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TopDownProteomicsi
P79483

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1377, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P79483, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P79483

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P79483

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P79483

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer that consists of an alpha chain HLA-DRA, a beta chain HLA-DRB1 and a peptide (peptide-MHCII) (PubMed:17583734, PubMed:18697946). Newly synthesized alpha and beta chains forms a heterodimer (MHCII) that associates with the CD74/invariant chain (Ii) in the endoplasmic reticulum (ER). Ii is a trimer composed of three subunits and each subunit interacts with one MHCII dimer, blocking the peptide-binding cleft. As a result, MHCII molecules can not bind peptides present in the ER (By similarity). The complex of MHCII and CD74/Ii is transported in vesicles from ER to Golgi to lysosomes, where it encounters antigenic peptides generated via proteolysis of endocytosed antigens. MHCII dimers are dissociated from CD74/Ii by the combined action of proteolysis and HLA-DM (By similarity). Lysosomal enzymes such as cathepsin, degrade CD74/Ii leaving a 24 amino acid remnant called class II-associated Ii or CLIP.

Interacts (via the peptide binding cleft) with CLIP; this interaction inhibits antigen peptide binding before entry in the endosomal compartment. The displacement of CLIP and replacement by a high affinity peptide in lysosomes is performed by HLA-DM heterodimer. HLA-DM catalyzes CLIP dissociation from MHCII, stabilizes empty MHCII and mediates the selection of high affinity peptides (By similarity).

Interacts with HLA-DM heterodimer; this interaction is direct (By similarity).

Interacts with TCR (via CDR3) (By similarity).

Interacts (via beta-2 domain) with CD4 coreceptor (via Ig-like V-type domain); this interaction is of exceptionally low affinity yet necessary for optimal recognition of antigenic peptides (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109370, 14 interactors

Protein interaction database and analysis system

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IntActi
P79483, 8 interactors

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P79483

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P79483, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P79483

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P79483

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 214Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 124Beta-1Add BLAST95
Regioni125 – 227Beta-2Add BLAST103

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The beta-1 domain is a structural part of the peptide-binding cleft. It contains one alpha helix and 4 beta sheets, respectively forming part of the wall and the floor of the peptide-binding cleft. The other 4 beta sheets of the floor and the second alpha helix wall is formed by the alpha-1 domain of HLA-DRA. Forms hydrogen bonds with the peptide main chain via conserved amino acid in most HLA-DRB molecules. The polymorphic residues accomodate the side chains of the peptide conferring peptide specificity to distinct HLA-DRB3 alleles (PubMed:17583734, PubMed:18697946). The peptide-bound beta-1 domain forms hydrogen bonds with CDR2 and CDR3 alpha-domains of TCR (By similarity).By similarity2 Publications
The beta-2 Ig-like domain mediates the interaction with CD4 coreceptor.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P79483

Identification of Orthologs from Complete Genome Data

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OMAi
FSNGMER

Database of Orthologous Groups

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OrthoDBi
1249505at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P79483

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR000353, MHC_II_b_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654, C1-set, 1 hit
PF00969, MHC_II_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407, IGc1, 1 hit
SM00921, MHC_II_beta, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P79483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):29,962
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC3AE68D3B10EAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A182DWH4A0A182DWH4_HUMAN
HLA class II histocompatibility ant...
HLA-DRB3
266Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Highly polymorphic. Polymorphic residues encode for the beta-1 domain of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The sequence shown is that of DRB3*01:01. The sequences of common representative alleles of serologically distinct allele groups as defined in the catalog of common and well-documented HLA alleles, are described as variants of DRB3*01:01. The most frequent alleles in human population are DRB3*01:01 (DR52a), DRB3*02:02 (DR52b) and DRB3*03:01 (DR52c) (PubMed:23510415). Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, leading to neonatal alloimmune thrombocytopenia (NAIT) (PubMed:19494351, PubMed:19535639). In the context of hematological malignancy and T cell transplantation, alleles DRB3*01:01 and DRB3*02:02 present minor histocompatibility antigens derived respectively from host PTK2B and MR1 proteins, contributing to T cell-mediated graft-versus-leukemia effect and complete remission (PubMed:19706888). Allele DRB3*03:01 plays an important role in the outcome of HLA-identical sex-mismatched organ transplantation. Presents to T-helper cells a minor histocompatibility antigen encoded by the Y chromosome RPS4Y1 (VIKVNDTVQI), leading to the maturation of dendritic cells and expansion of antigen-specific cytotoxic T cells, ultimately triggering transplant rejection (PubMed:12944060).5 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06073937L → S in allele DRB3*01:04. 1
Natural variantiVAR_06074038E → Q in allele DRB3*02:12. Corresponds to variant dbSNP:rs1071747Ensembl.1
Natural variantiVAR_06074139L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01668640R → C in allele DRB3*01:02. 1
Natural variantiVAR_06074240R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs1071748Ensembl.1
Natural variantiVAR_06074340R → S in allele DRB3*01:14. Corresponds to variant dbSNP:rs1136752Ensembl.1
Natural variantiVAR_06074441K → T in allele DRB3*01:14. Corresponds to variant dbSNP:rs200581589Ensembl.1
Natural variantiVAR_06074655Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs147440497Ensembl.1
Natural variantiVAR_06074555Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06074757D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs202185589Ensembl.1
Natural variantiVAR_06074857D → N in allele DRB3*01:05. Corresponds to variant dbSNP:rs142793258Ensembl.1
Natural variantiVAR_06074958R → I in allele DRB3*01:11. Corresponds to variant dbSNP:rs1407020168Ensembl.1
Natural variantiVAR_06075059Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02. Corresponds to variant dbSNP:rs138849995Ensembl.1
Natural variantiVAR_06075266F → L in allele DRB3*01:13. Corresponds to variant dbSNP:rs707956Ensembl.1
Natural variantiVAR_06075366F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075166F → S in allele DRB3*02:03. Corresponds to variant dbSNP:rs200042906Ensembl.1
Natural variantiVAR_06075466F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs200042906Ensembl.1
Natural variantiVAR_06075567L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075667L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant dbSNP:rs1059580Ensembl.1
Natural variantiVAR_06075768R → S in allele DRB3*01:10. Corresponds to variant dbSNP:rs774894415Ensembl.1
Natural variantiVAR_06075880T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs79606458Ensembl.1
Natural variantiVAR_06075984R → L in allele DRB3*02:23. 1
Natural variantiVAR_06076086V → A in allele DRB3*02:16. Corresponds to variant dbSNP:rs144532965Ensembl.1
Natural variantiVAR_06076286V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant dbSNP:rs144532965Ensembl.1
Natural variantiVAR_06076186V → S in allele DRB3*02:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076387A → E in allele DRB3*02:18. 1
Natural variantiVAR_06076489S → H in allele DRB3*02:16; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076589S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24. Corresponds to variant dbSNP:rs41541218Ensembl.1
Natural variantiVAR_06076696L → F in allele DRB3*02:17. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_06076796L → I in allele DRB3*02:11. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_033396102G → A. Corresponds to variant dbSNP:rs17878857Ensembl.1
Natural variantiVAR_060768103R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant dbSNP:rs1059598Ensembl.1
Natural variantiVAR_060769106N → T in allele DRB3*02:15. Corresponds to variant dbSNP:rs115817940Ensembl.1
Natural variantiVAR_060770113G → R in allele DRB3*01:12. 1
Natural variantiVAR_033397114V → A. Corresponds to variant dbSNP:rs1136778Ensembl.1
Natural variantiVAR_060771115G → A in allele DRB3*02:14. 1
Natural variantiVAR_060772115G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant dbSNP:rs41556512Ensembl.1
Natural variantiVAR_060773169A → T in allele DRB3*03:01. Corresponds to variant dbSNP:rs75709987Ensembl.1
Natural variantiVAR_060774178Q → H in allele DRB3*03:01. Corresponds to variant dbSNP:rs139485758Ensembl.1
Natural variantiVAR_060775193V → F in allele DRB3*02:01. 1
Natural variantiVAR_060776212A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01. Corresponds to variant dbSNP:rs142204283Ensembl.1
Natural variantiVAR_060777218R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11. Corresponds to variant dbSNP:rs147669022Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00522 mRNA Translation: CAA23781.1
X04055 Genomic DNA No translation available.
X04058 Genomic DNA No translation available.
U66825 mRNA Translation: AAD43828.1
AF026467 Genomic DNA Translation: AAC05599.1
AF199236 mRNA Translation: AAF13065.2
U95819 mRNA Translation: AAD00819.1
AY138123 mRNA Translation: AAN15205.1
A06800 mRNA Translation: CAA00596.1
AL662842 Genomic DNA No translation available.
AL929581 Genomic DNA No translation available.
CR788283 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06607.1
BC008987 mRNA Translation: AAH08987.1
BC106057 mRNA Translation: AAI06058.1
M17380 mRNA Translation: AAA59804.1
AF192258 mRNA Translation: AAF26358.1
AF192259 mRNA Translation: AAF26359.1
FJ515276 Genomic DNA Translation: ACL50609.1
AY291205 Genomic DNA Translation: AAP43643.1
AF148518 Genomic DNA Translation: AAF67837.1
AF081677 Genomic DNA Translation: AAC32202.1
AY271986 Genomic DNA Translation: AAP23230.1
AM747470 Genomic DNA Translation: CAO00528.1
EU873151 Genomic DNA Translation: ACF33221.1
EU873152 Genomic DNA Translation: ACF33222.1
EU873153 Genomic DNA Translation: ACF33223.1
X91639 Genomic DNA No translation available.
AF208484 Genomic DNA Translation: AAF23165.1
AF208485 Genomic DNA Translation: AAF23166.1
AJ290395 Genomic DNA Translation: CAC27417.1
AF427138 Genomic DNA Translation: AAL26538.1
AF455114 Genomic DNA Translation: AAL57866.1
AF461431 Genomic DNA Translation: AAL66370.1
AJ564210 Genomic DNA Translation: CAD91915.2
AY958608 Genomic DNA Translation: AAY28717.1
DQ311653 Genomic DNA Translation: ABC33924.1
AM413002 Genomic DNA Translation: CAL85628.1
FN424163 Genomic DNA Translation: CAZ66795.1
FN424162 Genomic DNA Translation: CAZ66766.1
AF177216 Genomic DNA Translation: AAD53911.1
AF361865 Genomic DNA Translation: AAK38297.1
AY042679 Genomic DNA Translation: AAK94514.1
U36826 Genomic DNA Translation: AAB63531.1
U94590 Genomic DNA Translation: AAB53324.1
X95760 Genomic DNA Translation: CAA65066.1
Y13715 Genomic DNA Translation: CAA74043.1
AJ001255 Genomic DNA Translation: CAA04629.1
AJ242860 Genomic DNA Translation: CAB62390.1
AJ242862 Genomic DNA Translation: CAB62392.1
AJ315477 Genomic DNA Translation: CAC86562.1
AF028012 Genomic DNA Translation: AAB94614.1
Y08063 Genomic DNA Translation: CAA69301.1
Y10180 Genomic DNA Translation: CAA71253.1
X86977 Genomic DNA No translation available.
AF152845 Genomic DNA Translation: AAD45286.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B60748
E28043
I37469, HLHU5D
PT0164
PT0165
PT0166
S03442

NCBI Reference Sequences

More...
RefSeqi
NP_072049.2, NM_022555.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307137; ENSP00000302517; ENSG00000196101
ENST00000383126; ENSP00000372607; ENSG00000231679

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3125

UCSC genome browser

More...
UCSCi
uc011fni.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA Translation: CAA23781.1
X04055 Genomic DNA No translation available.
X04058 Genomic DNA No translation available.
U66825 mRNA Translation: AAD43828.1
AF026467 Genomic DNA Translation: AAC05599.1
AF199236 mRNA Translation: AAF13065.2
U95819 mRNA Translation: AAD00819.1
AY138123 mRNA Translation: AAN15205.1
A06800 mRNA Translation: CAA00596.1
AL662842 Genomic DNA No translation available.
AL929581 Genomic DNA No translation available.
CR788283 Genomic DNA No translation available.
Z84814 Genomic DNA Translation: CAB06607.1
BC008987 mRNA Translation: AAH08987.1
BC106057 mRNA Translation: AAI06058.1
M17380 mRNA Translation: AAA59804.1
AF192258 mRNA Translation: AAF26358.1
AF192259 mRNA Translation: AAF26359.1
FJ515276 Genomic DNA Translation: ACL50609.1
AY291205 Genomic DNA Translation: AAP43643.1
AF148518 Genomic DNA Translation: AAF67837.1
AF081677 Genomic DNA Translation: AAC32202.1
AY271986 Genomic DNA Translation: AAP23230.1
AM747470 Genomic DNA Translation: CAO00528.1
EU873151 Genomic DNA Translation: ACF33221.1
EU873152 Genomic DNA Translation: ACF33222.1
EU873153 Genomic DNA Translation: ACF33223.1
X91639 Genomic DNA No translation available.
AF208484 Genomic DNA Translation: AAF23165.1
AF208485 Genomic DNA Translation: AAF23166.1
AJ290395 Genomic DNA Translation: CAC27417.1
AF427138 Genomic DNA Translation: AAL26538.1
AF455114 Genomic DNA Translation: AAL57866.1
AF461431 Genomic DNA Translation: AAL66370.1
AJ564210 Genomic DNA Translation: CAD91915.2
AY958608 Genomic DNA Translation: AAY28717.1
DQ311653 Genomic DNA Translation: ABC33924.1
AM413002 Genomic DNA Translation: CAL85628.1
FN424163 Genomic DNA Translation: CAZ66795.1
FN424162 Genomic DNA Translation: CAZ66766.1
AF177216 Genomic DNA Translation: AAD53911.1
AF361865 Genomic DNA Translation: AAK38297.1
AY042679 Genomic DNA Translation: AAK94514.1
U36826 Genomic DNA Translation: AAB63531.1
U94590 Genomic DNA Translation: AAB53324.1
X95760 Genomic DNA Translation: CAA65066.1
Y13715 Genomic DNA Translation: CAA74043.1
AJ001255 Genomic DNA Translation: CAA04629.1
AJ242860 Genomic DNA Translation: CAB62390.1
AJ242862 Genomic DNA Translation: CAB62392.1
AJ315477 Genomic DNA Translation: CAC86562.1
AF028012 Genomic DNA Translation: AAB94614.1
Y08063 Genomic DNA Translation: CAA69301.1
Y10180 Genomic DNA Translation: CAA71253.1
X86977 Genomic DNA No translation available.
AF152845 Genomic DNA Translation: AAD45286.1
PIRiB60748
E28043
I37469, HLHU5D
PT0164
PT0165
PT0166
S03442
RefSeqiNP_072049.2, NM_022555.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
SMRiP79483
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109370, 14 interactors
IntActiP79483, 8 interactors

Chemistry databases

BindingDBiP79483
ChEMBLiCHEMBL3460
DrugBankiDB05121, 1D09C3
DB11294, Coccidioides immitis spherule

PTM databases

GlyConnecti1377, 1 N-Linked glycan (1 site)
GlyGeniP79483, 1 site
iPTMnetiP79483
PhosphoSitePlusiP79483
SwissPalmiP79483

Genetic variation databases

BioMutaiHLA-DRB3
DMDMi34395491

Proteomic databases

jPOSTiP79483
MassIVEiP79483
MaxQBiP79483
PeptideAtlasiP79483
PRIDEiP79483
ProteomicsDBi57661
TopDownProteomicsiP79483

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3125

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101
ENST00000383126; ENSP00000372607; ENSG00000231679
GeneIDi3125
KEGGihsa:3125
UCSCiuc011fni.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3125
DisGeNETi3125

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-DRB3
HGNCiHGNC:4951, HLA-DRB3
MIMi612735, gene
neXtProtiNX_P79483
PharmGKBiPA35074

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

InParanoidiP79483
OMAiFSNGMER
OrthoDBi1249505at2759
PhylomeDBiP79483

Enzyme and pathway databases

PathwayCommonsiP79483
ReactomeiR-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling
SIGNORiP79483

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3125, 0 hits in 2 CRISPR screens
EvolutionaryTraceiP79483

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HLA-DRB3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3125
PharosiP79483, Tchem

Protein Ontology

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PROi
PR:P79483
RNActiP79483, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR000353, MHC_II_b_N
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00969, MHC_II_beta, 1 hit
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SM00921, MHC_II_beta, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9
, A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 1997
Last modified: April 7, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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