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UniProtKB - P79457 (UTY_MOUSE)
Protein
Histone demethylase UTY
Gene
Uty
Organism
Mus musculus (Mouse)
Status
Functioni
Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity.
By similarityCatalytic activityi
- 2 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N6-methyl-L-lysyl27-[histone H3] + 2 succinateBy similarityEC:1.14.11.68By similarity
Cofactori
Protein has several cofactor binding sites:- L-ascorbateBy similarity
- Fe2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 958 | IronBy similarity | 1 | |
Metal bindingi | 960 | IronBy similarity | 1 | |
Metal bindingi | 1038 | IronBy similarity | 1 | |
Metal bindingi | 1143 | ZincBy similarity | 1 | |
Metal bindingi | 1146 | ZincBy similarity | 1 | |
Metal bindingi | 1170 | ZincBy similarity | 1 | |
Metal bindingi | 1173 | ZincBy similarity | 1 |
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- histone H3-methyl-lysine-36 demethylase activity Source: MGI
- histone H3-tri/di-methyl-lysine-27 demethylase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- canonical Wnt signaling pathway Source: MGI
- cardiac muscle cell contraction Source: MGI
- embryonic organ development Source: MGI
- establishment of protein localization Source: MGI
- heart development Source: MGI
- heart morphogenesis Source: MGI
- heterochromatin assembly Source: MGI
- histone H3-K27 demethylation Source: GO_Central
- in utero embryonic development Source: MGI
- regulation of gene expression Source: MGI
Keywordsi
Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3214842, HDMs demethylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Histone demethylase UTY (EC:1.14.11.68By similarity)Alternative name(s): Male-specific histocompatibility antigen H-YDB Ubiquitously transcribed TPR protein on the Y chromosome Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein [histone H3]-trimethyl-L-lysine(27) demethylase UTYCurated |
Gene namesi | Name:Uty Synonyms:Kdm6c |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894810, Uty |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- MLL3/4 complex Source: GO_Central
Other locations
- protein-containing complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106413 | 1 – 1212 | Histone demethylase UTYAdd BLAST | 1212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 752 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P79457 |
PaxDbi | P79457 |
PRIDEi | P79457 |
ProteomicsDBi | 297903 |
PTM databases
iPTMneti | P79457 |
PhosphoSitePlusi | P79457 |
Interactioni
Subunit structurei
Binds TLE1 and TLE2.
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000070012 |
Miscellaneous databases
RNActi | P79457, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 88 – 121 | TPR 1Add BLAST | 34 | |
Repeati | 125 – 158 | TPR 2Add BLAST | 34 | |
Repeati | 165 – 193 | TPR 3Add BLAST | 29 | |
Repeati | 200 – 233 | TPR 4Add BLAST | 34 | |
Repeati | 245 – 278 | TPR 5Add BLAST | 34 | |
Repeati | 279 – 312 | TPR 6Add BLAST | 34 | |
Repeati | 313 – 346 | TPR 7Add BLAST | 34 | |
Repeati | 347 – 380 | TPR 8Add BLAST | 34 | |
Domaini | 907 – 1070 | JmjCPROSITE-ProRule annotationAdd BLAST | 164 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 530 – 555 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 865 – 886 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the UTX family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1124, Eukaryota KOG1246, Eukaryota |
InParanoidi | P79457 |
PhylomeDBi | P79457 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
P79457-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS
60 70 80 90 100
FFGFLTRCKD GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL
110 120 130 140 150
LEDYSKALSS YQRYYSLQTD YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE
160 170 180 190 200
VLYVDPNFCR AKEIHLRLGF MFKMNTDYES SLKHFQLALI DCNVCTLSSV
210 220 230 240 250
EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV LQQLGWMHHN
260 270 280 290 300
MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV
310 320 330 340 350
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW
360 370 380 390 400
MDLGILYESC NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP
410 420 430 440 450
QSSLQNKTKL LPSIEEAWSL PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA
460 470 480 490 500
SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF QTGSTRYLQA ASTNDQNQNG
510 520 530 540 550
NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK SLTSKTSRKD
560 570 580 590 600
RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV
610 620 630 640 650
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT
660 670 680 690 700
EQTHIVTSFI SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS
710 720 730 740 750
IYSSSTEVLK ACRSLGKNGL SNGHILLDIC PPPRPPTSPY PPLPKEKLNP
760 770 780 790 800
PTPSIYLENK RDAFFPPLHQ FCINPKNPVT VIRGLAGALK LDLGLFSTKT
810 820 830 840 850
LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS HTTIAKYAQY
860 870 880 890 900
QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI
910 920 930 940 950
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV
960 970 980 990 1000
PGSRIPGHQE NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF
1010 1020 1030 1040 1050
LMSSWWPNLE DLYEANVPVY RFIQRPGDLV WINAGTVHWV QAIGWCNNIT
1060 1070 1080 1090 1100
WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV PMVHLSWNMA RNIKVSDPKL
1110 1120 1130 1140 1150
FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA PYCSICEVEV
1160 1170 1180 1190 1200
FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD
1210
QFTLAPSLSS AS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q504 | E9Q504_MOUSE | Histone demethylase UTY | Uty | 1,111 | Annotation score: | ||
Q3UQE8 | Q3UQE8_MOUSE | Histone demethylase UTY | Uty | 1,149 | Annotation score: | ||
D3Z2A3 | D3Z2A3_MOUSE | Histone demethylase UTY | Uty | 646 | Annotation score: | ||
G3X9F2 | G3X9F2_MOUSE | Histone demethylase UTY | Uty | 1,212 | Annotation score: | ||
E9PWW8 | E9PWW8_MOUSE | Histone demethylase UTY | Uty | 1,211 | Annotation score: | ||
D6RJL0 | D6RJL0_MOUSE | Histone demethylase UTY | Uty | 78 | Annotation score: | ||
D6RFT4 | D6RFT4_MOUSE | Histone demethylase UTY | Uty | 144 | Annotation score: | ||
F7BBC1 | F7BBC1_MOUSE | Histone demethylase UTY | Uty | 100 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1069 | E → Q in CAA70422 (PubMed:8944031).Curated | 1 | |
Sequence conflicti | 1149 – 1212 | EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422 (PubMed:8944031).CuratedAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF057367 mRNA Translation: AAC67385.1 Y09222 mRNA Translation: CAA70422.1 |
CCDSi | CCDS41216.1 |
PIRi | T42387 T42729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF057367 mRNA Translation: AAC67385.1 Y09222 mRNA Translation: CAA70422.1 |
CCDSi | CCDS41216.1 |
PIRi | T42387 T42729 |
3D structure databases
SMRi | P79457 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000070012 |
PTM databases
iPTMneti | P79457 |
PhosphoSitePlusi | P79457 |
Proteomic databases
MaxQBi | P79457 |
PaxDbi | P79457 |
PRIDEi | P79457 |
ProteomicsDBi | 297903 |
Organism-specific databases
MGIi | MGI:894810, Uty |
Phylogenomic databases
eggNOGi | KOG1124, Eukaryota KOG1246, Eukaryota |
InParanoidi | P79457 |
PhylomeDBi | P79457 |
Enzyme and pathway databases
Reactomei | R-MMU-3214842, HDMs demethylate histones |
Miscellaneous databases
ChiTaRSi | Uty, mouse |
PROi | PR:P79457 |
RNActi | P79457, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR003347, JmjC_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF02373, JmjC, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UTY_MOUSE | |
Accessioni | P79457Primary (citable) accession number: P79457 Secondary accession number(s): O97979 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families